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Reposted by Stephen McLaughlin

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 6d

Considering a PhD in molecular biology?
Make sure to check out the projects on offer at the LMB!
www2.mrc-lmb.cam.ac.uk/students/int...
General applications by 2nd DEC.
US Gates Scholarship applications by 15th OCT.
#PhD

Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025

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Stephen McLaughlin @lmbbiophysics.bsky.social · 29d

Is that a pointer, looks more like a jedi sword!

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Stephen McLaughlin @lmbbiophysics.bsky.social · Aug 19

Excited that we are only two weeks away for our Next Generation Biophysics Symposium 2025. We have a fantastic line-up of speakers. Registration is closing soon. Come in person or view on-line
#Biophysics #SingleMolecule #CryoEM #nmr #proteindynamics

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Reposted by Stephen McLaughlin

Syma Khalid @sykhalid.bsky.social · Aug 10

Carol Robinson on Desert Island Discs - have a listen friends: www.bbc.co.uk/sounds/play/...
An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless)
@kavlioxford.bsky.social

Desert Island Discs - Professor Dame Carol Robinson, scientist - BBC Sounds

Dame Carol Robinson, scientist, shares the soundtrack of her life with Lauren Laverne.

www.bbc.co.uk

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Reposted by Stephen McLaughlin

Sjors Scheres @sjorsscheres.bsky.social · Aug 12

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳

How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.

www.cell.com/structure/fu...

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps

Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...

www.cell.com

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Reposted by Stephen McLaughlin

Phil Holliger @philholliger.bsky.social · Jul 14

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology

Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

www.jobs.ac.uk

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Reposted by Stephen McLaughlin

Alessandro Costa @costalaboratory.bsky.social · Jul 21

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Postdoctoral Fellow - Costa Lab

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

crick.wd3.myworkdayjobs.com

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Reposted by Stephen McLaughlin

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Jul 15

Want to hear from experts about how new and emerging technologies can be harnessed to answer complex biological questions?
Don’t mis the 2025 Next Generation Biophysics Symposium on Wednesday 3rd September!
Find out more details and register here: www3.mrc-lmb.cam.ac.uk/sites/nextgen/

AstraZeneca, MRC Laboratory of Molecular Biology, Imperial College London, MRC Laboratory of Medical Sciences
Next Generation Biophysics Symposium 2025
Wednesday 3rd September 2025
Hybrid Symposium (Zoom & MRC LMB, Cambridge)
Keynote Speaker: Professor Cees Dekker
Registration open

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Reposted by Stephen McLaughlin

Kelly Nguyen @kellythd-nguyen.bsky.social · Jul 11

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Jul 11

Sebastian Balch, Zala Sekne & Elsa Franco-Echevarría in @kellythd-nguyen.bsky.social's group have confirmed the existence of dimeric telomerase and illustrated how it is key to telomere maintenance:
www2.mrc-lmb.cam.ac.uk/first-struct...

#LMBResearch @yiliangding.bsky.social @rdaslab.bsky.social 🧪

Structure of telomerase dimer with key catalytic codes and H/ACA RNPs highlighted with schematic illustrating how dimer disruption leads to shortened telomeres and disease mutations of the dimers causes premature ageing diseases

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Reposted by Stephen McLaughlin

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Jun 23

Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs

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Reposted by Stephen McLaughlin

Derivery Lab - MRC LMB @deriverylab.bsky.social · Jun 23

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

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Stephen McLaughlin @lmbbiophysics.bsky.social · Jun 20

Excited for our program of speakers at Next Generation Biophysics 2025. Come join us as registration is now open either in person or online:
www3.mrc-lmb.cam.ac.uk/sites/nextge...

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Reposted by Stephen McLaughlin

Ewerslab @ewerslab.bsky.social · May 9

Madhavi Krishnans lab with an absolutely amazing new measurement technique:
Measurements of molecular size and shape on a chip | Science www.science.org/doi/10.1126/...

Measurements of molecular size and shape on a chip

Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...

www.science.org

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Reposted by Stephen McLaughlin

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Mar 31

How do SMC complexes capture DNA? 🧪

Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway.

Read more: tinyurl.com/4s8nrrkk

#LMBResearch

Schematic illustrating the structural changes undergone by MukBEF SMC complex during DNA capture and ingestion.

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Stephen McLaughlin @lmbbiophysics.bsky.social · Mar 14

Great opportunity in a fantastic lab

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Mar 14

We’re looking for an enthusiastic #postdoc to join @suyangzhang.bsky.social’s group in the LMB’s Structural Studies Division, combining biochemical & structural approaches to investigate the mechanism of co-transcriptional splicing.
www.nature.com/naturecareer...
Apply by 21 APR
#PostdocJobs #CryoEM

Suyang Zhang, smiling wearing a purple shirt and dark rimmed spectacles.

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Reposted by Stephen McLaughlin

Kelly Nguyen @kellythd-nguyen.bsky.social · Mar 6

Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome.
www.science.org/doi/10.1126/...

Structural mechanism of LINE-1 target-primed reverse transcription

Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...

www.science.org

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Reposted by Stephen McLaughlin

Journal of Cell Science @jcellsci.bsky.social · Feb 10

Our latest ‘Cell Scientist to Watch’ interview is with Kelly Nguyen @kellythd-nguyen.bsky.social @mrclmb.bsky.social. We learn about Kelly’s career, her advice on collaborative research and her passion for martial arts.
journals.biologists.com/jcs/article/...

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Reposted by Stephen McLaughlin

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Feb 3

Great position for a postdoc to join @igreger.bsky.social’s group in the LMB’s Neurobiology Division, using diverse methods to study synaptic AMPA glutamate receptors.
Read more about the job here: www.nature.com/naturecareer...
Apply by 20 FEB
#PostdocJobs #ScienceJobs

Ingo Greger sat in front of a computer screen displaying an AMPA Receptor structure

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Reposted by Stephen McLaughlin

Sjors Scheres @sjorsscheres.bsky.social · Jan 29

The @mrclmb.bsky.social believes in the benefits of a diverse workforce, and is proud of its history in training next-gen scientists. Three-year postdoc fellowships are now available for those who self-identify as being from a (mixed) Black heritage background.
www2.mrc-lmb.cam.ac.uk/recruitment/...

Rising Talent Fellowship - MRC Laboratory of Molecular Biology

RISING TALENT FELLOWSHIP The MRC Laboratory of Molecular Biology (LMB) is proud to launch the next application round of its three-year fully funded

www2.mrc-lmb.cam.ac.uk

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Reposted by Stephen McLaughlin

Science of the Times Podcast @scienceofthetimes.bsky.social · Jan 26

We (Tim Coulson & Syma Khalid) are launching a new science podcast. We will discuss recently published work of world leading scientists in an accessible and non-technical style. Topics will include, AI, search for alien life, latest treatments for diseases, quantum computers, science of football.

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Reposted by Stephen McLaughlin

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Jan 23

The LMB Rising Talent Fellowship for Black heritage scientists is open for applicants!
With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience.
To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/... 
Please share!

Apply now!
LMB Rising Talent Fellowship
3-year postdoctoral fellowship for Black heritage scientists
Visit www.mrc-lmb.cam.ac.uk for more information

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Reposted by Stephen McLaughlin

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Jan 23

Congratulations to John Sutherland, Group Leader in the LMB’s PNAC Division, who has received the Award in Early Earth and Life Sciences – Stanley Miller Medal from @nasonline.org for his work investigating the chemical origins of life on Earth.

www2.mrc-lmb.cam.ac.uk/john-sutherl...

#LMBNews

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Reposted by Stephen McLaughlin

Vicente Planelles Herrero @vicenteph.bsky.social · Jan 16

Check it out, is finally out!!

The EMBO Journal @embojournal.org · Jan 15

How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division?
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....

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Reposted by Stephen McLaughlin

Janet Kumita @jrkumita.bsky.social · Jan 7

‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk

Experience Postgrad Life Sciences | Enhancing diversity among life scientists of the future

www.exppg.lifesci.cam.ac.uk

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Reposted by Stephen McLaughlin

Alessandro Costa @costalaboratory.bsky.social · Dec 11

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.

Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!

3 postdoc positions advertised soon.

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