Lucia Stefanini
@lu-stefanini-lab.bsky.social
Mom, scientist, citizen of the world in love with my family, platelets, immunology, mountains, bicycles, gardening, cooking, sailing, books, long walks…
Reposted by Lucia Stefanini
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 5:37 PM
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
Reposted by Lucia Stefanini
Reposted by Lucia Stefanini
Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
June 4, 2025 at 7:38 PM
Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
Reposted by Lucia Stefanini
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
May 5, 2025 at 10:00 AM
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
Reposted by Lucia Stefanini
🆕 “Science and medicine in the USA are being violently dismembered while the world watches [...] bullies are only emboldened by acquiescence or indifference.”
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
April 25, 2025 at 12:28 PM
🆕 “Science and medicine in the USA are being violently dismembered while the world watches [...] bullies are only emboldened by acquiescence or indifference.”
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
Reposted by Lucia Stefanini
We urge all leaders, for the good of their nations’ health, not to ignore or contradict advice that is supported by a consensus of evidence from research.
https://go.nature.com/43Rfr5a
https://go.nature.com/43Rfr5a
Vaccines save lives. Leaders must champion them
Attacks on vaccines and the cancellation of research into what causes vaccine hesitancy puts people in harm’s way.
go.nature.com
March 18, 2025 at 5:27 PM
We urge all leaders, for the good of their nations’ health, not to ignore or contradict advice that is supported by a consensus of evidence from research.
https://go.nature.com/43Rfr5a
https://go.nature.com/43Rfr5a
Reposted by Lucia Stefanini
“We found that a single iron infusion in the third trimester can achieve what oral iron tablets taken every day during a pregnancy cannot.”
#ReproSky #ObGynSky 🧪
medicalxpress.com/news/2025-01...
#ReproSky #ObGynSky 🧪
medicalxpress.com/news/2025-01...
Healthier mothers, healthier babies: Iron trial could transform pregnancy care worldwide
A major trial has found a single iron infusion in the third trimester can significantly reduce anemia in pregnant women and outperform the efficacy of iron tablets—the current recommended standard of ...
medicalxpress.com
January 7, 2025 at 12:28 AM
“We found that a single iron infusion in the third trimester can achieve what oral iron tablets taken every day during a pregnancy cannot.”
#ReproSky #ObGynSky 🧪
medicalxpress.com/news/2025-01...
#ReproSky #ObGynSky 🧪
medicalxpress.com/news/2025-01...
Reposted by Lucia Stefanini
#NoTimeToDie! @vijayrathinam.bsky.social Weight &co show @cp-cell.bsky.social that pyroptotic cells release extracellular vesicles which transplant gasdermin D #GSDMD pores to neighboring cells propagating cell death! t.co/XgU6jt15aF Free link to the paper 👉 authors.elsevier.com/a/1kMQgL7PXq...
https://www.cell.com/cell/abstract/S0092-8674(24)01334-5
t.co
December 31, 2024 at 6:07 PM
#NoTimeToDie! @vijayrathinam.bsky.social Weight &co show @cp-cell.bsky.social that pyroptotic cells release extracellular vesicles which transplant gasdermin D #GSDMD pores to neighboring cells propagating cell death! t.co/XgU6jt15aF Free link to the paper 👉 authors.elsevier.com/a/1kMQgL7PXq...
Reposted by Lucia Stefanini
Reposted by Lucia Stefanini
Neutrophils (red) and Platelets (cyan) chasing each other in the murine ischemic stroke brain... (1/2 reduced speed)
November 22, 2024 at 5:09 PM
Neutrophils (red) and Platelets (cyan) chasing each other in the murine ischemic stroke brain... (1/2 reduced speed)