@mairikilkenny.bsky.social
Senior Teaching Associate, University of Cambridge. All views my own.
Reposted
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
January 18, 2026 at 2:30 PM
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
Reposted
Do your New Year resolutions include a plan to leave higher education? These researchers explain how to reinvent your career.
go.nature.com/49icUDp
go.nature.com/49icUDp
Fresh starts: how to thrive when you leave academia
Do your New Year resolutions include a plan to leave higher education? These researchers explain how to reinvent your career.
go.nature.com
January 12, 2026 at 6:12 PM
Do your New Year resolutions include a plan to leave higher education? These researchers explain how to reinvent your career.
go.nature.com/49icUDp
go.nature.com/49icUDp
Reposted
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 11:49 PM
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the people who shaped science this year and were chosen for Nature’s 10. 🧪
Nature’s 10: Ten people who shaped science in 2025
A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the remarkable people chosen for Nature’s 10.
go.nature.com
December 8, 2025 at 5:12 PM
A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the people who shaped science this year and were chosen for Nature’s 10. 🧪
Reposted
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Reposted
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/4rvXH8Y
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/4rvXH8Y
We are all mosaics: vast genetic diversity found between cells in a single person
Nature - Technical advances allow researchers to trace the genetic changes that occur over time.
go.nature.com
November 29, 2025 at 4:36 PM
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/4rvXH8Y
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/4rvXH8Y
Reposted
Gene editing could one day be harnessed to provide a one-stop treatment for a common cause of heart disease
go.nature.com/4nSyzGc
go.nature.com/4nSyzGc
CRISPR vs. cholesterol: can gene editing prevent heart disease?
Promising results from a small clinical trial highlight a growing interest in designing gene-editing treatments for common illnesses.
go.nature.com
November 13, 2025 at 4:46 PM
Gene editing could one day be harnessed to provide a one-stop treatment for a common cause of heart disease
go.nature.com/4nSyzGc
go.nature.com/4nSyzGc
Reposted
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
November 7, 2025 at 10:15 AM
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
Reposted
Cambridge Amgen Scholars Programme 2026 is now open. Great opportunity for undergrad students from UK and Europe to join Cambridge labs.
Happy hear from anyone interested in joining our group at @cambiochem.bsky.social
amgenscholars.bio.cam.ac.uk
Happy hear from anyone interested in joining our group at @cambiochem.bsky.social
amgenscholars.bio.cam.ac.uk
Home | Amgen Scholars Programme
amgenscholars.bio.cam.ac.uk
November 7, 2025 at 12:58 PM
Cambridge Amgen Scholars Programme 2026 is now open. Great opportunity for undergrad students from UK and Europe to join Cambridge labs.
Happy hear from anyone interested in joining our group at @cambiochem.bsky.social
amgenscholars.bio.cam.ac.uk
Happy hear from anyone interested in joining our group at @cambiochem.bsky.social
amgenscholars.bio.cam.ac.uk
Reposted
If this gene therapy approach is as good as it looks, this is amazing.
September 24, 2025 at 12:23 PM
If this gene therapy approach is as good as it looks, this is amazing.
Reposted
Download this PDB-101 poster highlighting common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme
PDB101: Learn: Flyers, Posters, & Calendars: Posters: Folding of Protein Domains
This poster highlights common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme.
pdb101.rcsb.org
September 22, 2025 at 7:44 PM
Download this PDB-101 poster highlighting common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme
Reposted
This is a cool approach!
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:55 PM
This is a cool approach!
Reposted
In the face of climate change, the race to understand life on Earth is on.
@ebpgenome.bsky.social is scaling up tenfold to sequence all known species by 2035.
At EMBL-EBI, we annotate these genomes, making them openly available for the global research community.
www.ebi.ac.uk/about/news/a...
@ebpgenome.bsky.social is scaling up tenfold to sequence all known species by 2035.
At EMBL-EBI, we annotate these genomes, making them openly available for the global research community.
www.ebi.ac.uk/about/news/a...
Global effort to sequence all life on Earth ramps up
The Earth BioGenome Project is accelerating its efforts tenfold to sequence all life on Earth by 2035.
www.ebi.ac.uk
September 9, 2025 at 2:13 PM
In the face of climate change, the race to understand life on Earth is on.
@ebpgenome.bsky.social is scaling up tenfold to sequence all known species by 2035.
At EMBL-EBI, we annotate these genomes, making them openly available for the global research community.
www.ebi.ac.uk/about/news/a...
@ebpgenome.bsky.social is scaling up tenfold to sequence all known species by 2035.
At EMBL-EBI, we annotate these genomes, making them openly available for the global research community.
www.ebi.ac.uk/about/news/a...
Reposted
This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses.
buff.ly/Ieh84gj
buff.ly/Ieh84gj
August 26, 2025 at 10:02 AM
This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses.
buff.ly/Ieh84gj
buff.ly/Ieh84gj
Reposted
Aggresomes protect mRNA under stress in Escherichia coli
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky
Aggresomes protect mRNA under stress in Escherichia coli - Nature Microbiology
Ribonucleoprotein aggresomes exclude ribonucleases and protect mRNA to promote rapid translation reactivation and cellular recovery after stress alleviation in Escherichia coli.
www.nature.com
August 23, 2025 at 8:51 AM
Aggresomes protect mRNA under stress in Escherichia coli
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky
Reposted
(1/7)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Accelerating Biomolecular Modeling with AtomWorks and RF3
Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...
www.biorxiv.org
August 15, 2025 at 5:17 PM
(1/7)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Reposted
Undruggable No More: AI Hits Disordered Proteins, Unlocks Therapy Targets
David Baker’s Nobel Prize-winning lab has successfully designed high affinity binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome
www.genengnews.com/t...
David Baker’s Nobel Prize-winning lab has successfully designed high affinity binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome
www.genengnews.com/t...
Undruggable No More: AI Hits Disordered Proteins, Unlocks Therapy Targets
David Baker’s lab has successfully designed binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome.
www.genengnews.com
July 29, 2025 at 5:22 PM
Undruggable No More: AI Hits Disordered Proteins, Unlocks Therapy Targets
David Baker’s Nobel Prize-winning lab has successfully designed high affinity binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome
www.genengnews.com/t...
David Baker’s Nobel Prize-winning lab has successfully designed high affinity binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome
www.genengnews.com/t...
Reposted
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization
Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...
www.science.org
July 10, 2025 at 9:26 PM
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
What a way to celebrate Manchester’s cosmic legacy 🤩
Students from our Physics Society have constructed a remarkable 30,500-piece LEGO model of the iconic Lovell Telescope at Jodrell Bank.
@jodrellbank.bsky.social
Students from our Physics Society have constructed a remarkable 30,500-piece LEGO model of the iconic Lovell Telescope at Jodrell Bank.
@jodrellbank.bsky.social
June 27, 2025 at 7:28 AM
What a way to celebrate Manchester’s cosmic legacy 🤩
Students from our Physics Society have constructed a remarkable 30,500-piece LEGO model of the iconic Lovell Telescope at Jodrell Bank.
@jodrellbank.bsky.social
Students from our Physics Society have constructed a remarkable 30,500-piece LEGO model of the iconic Lovell Telescope at Jodrell Bank.
@jodrellbank.bsky.social
Reposted
“If I am elected, I will be an active, inclusive, and engaged Chancellor for a new era.”
A clip from the recent Cambridge Chancellor webinar.
(For more information on the election and to sign up for updates, please visit www.chancellorforanewera.co.uk . Thank you.)
#cambridge #cambridgechancellor
A clip from the recent Cambridge Chancellor webinar.
(For more information on the election and to sign up for updates, please visit www.chancellorforanewera.co.uk . Thank you.)
#cambridge #cambridgechancellor
June 24, 2025 at 10:42 AM
“If I am elected, I will be an active, inclusive, and engaged Chancellor for a new era.”
A clip from the recent Cambridge Chancellor webinar.
(For more information on the election and to sign up for updates, please visit www.chancellorforanewera.co.uk . Thank you.)
#cambridge #cambridgechancellor
A clip from the recent Cambridge Chancellor webinar.
(For more information on the election and to sign up for updates, please visit www.chancellorforanewera.co.uk . Thank you.)
#cambridge #cambridgechancellor
Reposted
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
June 20, 2025 at 9:38 AM
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Marking exams
June 18, 2025 at 11:32 AM
Marking exams
Reposted
🧬 Thrilled to share that our latest work, A landmark study uncovering intricate molecular details of the human DNA repair process.
📰 Press release: elifesciences.org/for-the-pres...
📄 Full article: elifesciences.org/reviewed-pre...
Proud of the team #DNADamage #CryoEM #CambridgeUniversity
📰 Press release: elifesciences.org/for-the-pres...
📄 Full article: elifesciences.org/reviewed-pre...
Proud of the team #DNADamage #CryoEM #CambridgeUniversity
May 27, 2025 at 2:08 PM
🧬 Thrilled to share that our latest work, A landmark study uncovering intricate molecular details of the human DNA repair process.
📰 Press release: elifesciences.org/for-the-pres...
📄 Full article: elifesciences.org/reviewed-pre...
Proud of the team #DNADamage #CryoEM #CambridgeUniversity
📰 Press release: elifesciences.org/for-the-pres...
📄 Full article: elifesciences.org/reviewed-pre...
Proud of the team #DNADamage #CryoEM #CambridgeUniversity
Reposted
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
May 26, 2025 at 4:56 PM
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM