Manideep Chavali
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manideep.bsky.social
Manideep Chavali
@manideep.bsky.social
190 followers 310 following 0 posts
Assistant Professor @ OHSU 🧠 | Neuroscientist: OPCs, vessels & brain mysteries. #newPI
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Reposted by Manideep Chavali
agarwal-neurolab.bsky.social
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...
www.cell.com
January 2, 2026 at 3:55 PM
Reposted by Manideep Chavali
jcb.org
Rodriguez Salazar, @caglaeroglu.bsky.social et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. rupress.org/jcb/article/...

📕 Part of The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025 #Mitochondria
December 7, 2025 at 4:15 PM
Reposted by Manideep Chavali
krishnanyamuna.bsky.social
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
December 17, 2025 at 12:46 AM
Reposted by Manideep Chavali
biorxivpreprint.bsky.social
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 16, 2025 at 10:32 PM
Reposted by Manideep Chavali
siegenthalerlab.bsky.social
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Micrscopy images of cleared cerebral brain tissue showing penetrating blood vessels (white) in mice - magenta cells are perivascular fibroblasts and cyan cells are perivascular macrophages - in control mice, both cell types are near the vessel termini by postnatal day 10 but in 'cKO' mice that lack expression of a tyrosine kinase receptor PDGFRa in fibroblasts, both the fibroblasts and macrophages are only partially covering the vessels. From Figure 4 of our paper - https://authors.elsevier.com/a/1m7fa2mzTkyfS
November 20, 2025 at 1:23 PM
Reposted by Manideep Chavali
auroralkraus.bsky.social
Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish."

lnkd.in/gN7z6th4
November 18, 2025 at 2:42 AM
Reposted by Manideep Chavali
ppimentel-coelho.bsky.social
Obituary: Jose Manuel García-Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers

Arantxa Cebrian-Silla, Mercedes Paredes, Arturo Alvarez-Buylla

onlinelibrary.wiley.com/doi/10.1002/...
Obituary: Jose Manuel García‐Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers
Click on the article title to read more.
onlinelibrary.wiley.com
November 14, 2025 at 8:16 PM
Reposted by Manideep Chavali
sheckyfeinblatt.bsky.social
Our postdoc ad is up on the SDB website! Come to Portland and study regenerative neurogenesis in planarians and zebrafish:
www.sdbonline.org/resource?Res...
Society for Developmental Biology | Resource
www.sdbonline.org
September 5, 2025 at 4:11 PM
Reposted by Manideep Chavali
nature.com
Nature research paper: Axonal injury is a targetable driver of glioblastoma progression

go.nature.com/4lFmpiN
Axonal injury is a targetable driver of glioblastoma progression - Nature
Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.
go.nature.com
August 20, 2025 at 3:48 PM
Reposted by Manideep Chavali
blacoste.bsky.social
Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging
Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience
How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...
doi.org
August 12, 2025 at 9:12 PM
Reposted by Manideep Chavali
ardemp.bskyverified.social
Fantastic new study on the role of TMEM63a in oligodendrocyte-dependent myelination in the CNS from the Swetha Murthy lab: pubmed.ncbi.nlm.nih.gov/40694323/
TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination - PubMed
Infantile hypomyelinating leukodystrophy 19 (HLD19) is a rare genetic disorder where patients exhibit reduced myelin in central nervous system (CNS) white matter tracts and present with varied neurolo...
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 6:21 PM
Reposted by Manideep Chavali
blacoste.bsky.social
#Cerebrovascular #Neurovascular
Reduction of neuronal activity mediated by blood-vessel regression in the adult brain - Nature Communications
The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regre...
www.nature.com
July 2, 2025 at 2:54 AM
Reposted by Manideep Chavali
biorxiv-neursci.bsky.social
Directional growth of developing myelin mediated by Wnt gradient and required for proper axon functions https://www.biorxiv.org/content/10.1101/2025.06.13.659097v1
June 15, 2025 at 8:15 AM
Reposted by Manideep Chavali
lyons-lab.bsky.social
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
www.nature.com
May 14, 2025 at 11:45 AM
Reposted by Manideep Chavali
ethanhugheslab.bsky.social
New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠

www.nature.com/articles/s41...
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications
Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...
www.nature.com
January 18, 2025 at 6:41 PM
Reposted by Manideep Chavali
biorxiv-neursci.bsky.social
Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity https://www.biorxiv.org/content/10.1101/2024.12.27.630559v1
December 28, 2024 at 8:16 AM