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@mannaa.bsky.social
19 followers 47 following 0 posts
physician/doctor, husband, father, geriatrician, intensivist, internal medicine, tech savvy, all things science
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Reposted
science.org
A new modeling-based analysis in #ScienceAdvances estimates that—if implemented today—net-zero climate mitigation measures could spare the globe 207,000 premature deaths and $2.2 trillion in economic damages from air pollution by 2030. https://scim.ag/42JNqLC
Beyond the limit: The estimated air pollution damages of overshooting the temperature target
Nonovershooting pathways improve air quality, preventing deaths and saving billions globally, especially in China and India.
scim.ag
October 21, 2025 at 5:46 PM
Reposted
erictopol.bsky.social
In a cohort of over 13,500 women with mean age ~72 years, >4,000 steps per day, at least 1-2 days per week, was associated with reduction in all-cause mortality and lower risk of cardiovascular disease
bjsm.bmj.com/content/earl...
October 22, 2025 at 12:22 AM
Reposted
jonathanjarry.bsky.social
An excellent write-up on our collective obsession with PROTEIN! by @erictopol.bsky.social.

You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.

open.substack.com/pub/erictopo...
Our Preoccupation With Protein Intake
The data on high protein diets, bars, supplements, and powders will surprise you
open.substack.com
September 5, 2025 at 5:42 PM
Reposted
erictopol.bsky.social
Beta blockers were routinely given to patients after a heart attack. 2 new randomized trials show conflicting results for patients with an ejection fraction of >40% #ESC2025
@nejm.org

nejm.org/doi/full/10....
nejm.org/doi/full/10....
August 30, 2025 at 3:41 PM
Reposted
agsjournal.bsky.social
A large proportion of US older adults on BZD or Z-drugs before hospitalization for a hip fracture continued the drugs within 180 days post hospital discharge. #geriatrics agsjournals.onlinelibrary.wiley.com/doi/10.1111/...
August 30, 2025 at 7:09 PM
Reposted
erictopol.bsky.social
p-tau217 predicts cognitive changes prior to any cognitive impairment (again)
"The era of disease-modifying therapy in Alzheimer's disease is just starting."
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
p-Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease
This diagnostic/prognostic study examines longitudinal data from studies of older patients without cognitive impairment to consider whether plasma phosphorylated tau 217 and tau positron emission tomo...
jamanetwork.com
August 25, 2025 at 3:46 PM
Reposted
erictopol.bsky.social
www.nature.com/articles/d41...
Repeated heatwaves can age you as much as smoking or drinking
Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing.
www.nature.com
August 26, 2025 at 4:20 PM
Reposted
erictopol.bsky.social
Markers of ultraprocessed foods linked to increased all-cause mortality
www.thelancet.com/journals/ecl...
Association of 37 markers of ultra-processing with all-cause mortality: a prospective cohort study in the UK Biobank
Total MUP-based definition UPF, five MUP categories, and several specific MUPs within these categories were significantly associated with all-cause mortality. Thus, interventions targeting UPF may be ...
www.thelancet.com
August 26, 2025 at 4:12 PM
Reposted
erictopol.bsky.social
We'll be seeing a lot more Super Agers in the future
Podcast w/ @carlzimmer.com w/transcript
podcasts.apple.com/us/podcast/h...
How to Be a Super Ager, with Eric Topol
Podcast Episode · The World as You’ll Know It: The Future Of Aging · 06/24/2025 · 33m
podcasts.apple.com
June 24, 2025 at 12:20 PM
Reposted
nature.com
Research is revealing the cellular mechanisms that link mental well-being and longevity

https://go.nature.com/40h70gQ
How your brain controls ageing — and why zombie cells could be key
Research is revealing the cellular mechanisms that link mental well-being and longevity.
go.nature.com
June 24, 2025 at 1:47 PM
Reposted
nature.com
The Vera C. Rubin Observatory in Chile has unveiled its first images, leaving astronomers in awe

https://go.nature.com/3GcuFZ1
First images from world’s largest digital camera leave astronomers in awe
Nature - The new observatory in Chile will map the entire southern sky every 3–4 nights.
go.nature.com
June 24, 2025 at 3:50 PM
Reposted
erictopol.bsky.social
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome. @naturemedicine.bsky.social
March 24, 2025 at 4:03 PM
Reposted
erictopol.bsky.social
Good summary on microplastics and our health risks
nymag.com/intelligence...
Everything You Ever Wanted to Know About Microplastics
They’re in our blood and our brains. They’re in newborns and the elderly, urban and rural, rich and poor. What are they doing to our bodies?
nymag.com
February 25, 2025 at 3:12 PM
Reposted
nature.com
Injecting old mice with an RNA molecule seems to reverse some signs of ageing — helping them to live longer, regrow hair and maintain their physical and mental abilities

https://go.nature.com/40F1BRv
RNA molecule rejuvenates ageing mice by restoring old cells
Mice injected with a microRNA molecule lived longer and had fewer markers of ageing, but it’s not yet known if the treatment would work in people.
go.nature.com
January 20, 2025 at 2:13 PM
Reposted
daniellebeckman.bsky.social
Out today at www.nature.com/articles/s41...
These numbers are crazy. A generation of young people with dementia waits for us in the near future, and we are not prepared for that. #NeuroCovid
Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory
January 12, 2025 at 1:06 AM
Reposted
nature.com.web.brid.gy
Earth breaches 1.5 °C climate limit for the first time: what does it mean?
Nature, Published online: 10 January 2025; doi:10.1038/d41586-025-00010-9 The threshold has been exceeded for only one year so far, but humanity is nearing the end of what many thought was a ‘safe zone’ as climate change worsens.
www.nature.com
January 10, 2025 at 6:22 PM
Reposted
natureportfolio.nature.com
From deciphering burnt Roman scrolls to reading crumbling cuneiform tablets, AI neural networks could give researchers more data than they’ve had in centuries. Read the Nature feature article. 🧪 🏺
How AI is unlocking ancient texts — and could rewrite history
From deciphering burnt Roman scrolls to reading crumbling cuneiform tablets, neural networks could give researchers more data than they’ve had in centuries.
go.nature.com
January 11, 2025 at 1:39 PM
Reposted
erictopol.bsky.social
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
The cover image portrays a human composed of proteins who is examining their health status (represented by the ECG monitoring interface) with the assistance of artificial intelligence (represented by the chip and binary codes).
January 10, 2025 at 6:56 PM
Reposted
nature.com.web.brid.gy
How the brain cleans itself during deep sleep
Nature, Published online: 10 January 2025; doi:10.1038/d41586-025-00007-4 Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ.
www.nature.com
January 10, 2025 at 8:17 PM