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markpitman.bsky.social
@markpitman.bsky.social
9 followers 79 following 2 posts
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Reposted
science.org
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more: scim.ag/41PWgYc
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
scim.ag
March 28, 2025 at 4:07 PM
Reposted
nygenome.org
We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the New York Genome Center

Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment.

For more on Dr. Ren: bit.ly/3DJXtah
Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center - March 27, 2025
Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025
bit.ly
March 27, 2025 at 4:02 PM
Reposted
astrojaz.bsky.social
flame nebula: hubble vs webb
Hubble’s image of a section of the Flame Nebula, which contains a mixture of light and dark brown colors and shows white stars. In this comparison, three low-mass objects are highlighted. In Hubble’s observation, the low-mass objects are hidden by the region’s dense dust and gas. Webb's image of a section of the Flame Nebula, which contains a mixture of reds, blues and browns, and shows red, blue, and white stars. In this comparison, three low-mass objects are highlighted. In Hubble’s observation, the low-mass objects are hidden by the region’s dense dust and gas. However, the objects are brought out in the Webb observation due to Webb's sensitivity to faint infrared light.
March 11, 2025 at 2:00 AM
Reposted
jwstfeed.bsky.social
New JWST image dropped: actively forming star system Lynds 483 (NIRCam image)

Credit:
NASA, ESA, CSA, STScI
esawebb.org/news/weic2503
At the centre is a thin vertical cloud known as Lynds 483 (L483) that is roughly shaped like an hourglass with irregular edges. The lower lobe is slightly cut off. The top lobe is seen in full, petering out at the top.
March 7, 2025 at 7:47 PM
Reposted
dijiang319.bsky.social
@science.org G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation | Science www.science.org/doi/10.1126/... @sahilbatra.bsky.social @benallwein.bsky.social @dirkremus.bsky.social www.mskcc.org/research/ski...
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
March 7, 2025 at 4:24 PM
Reposted
jonathanslater.bsky.social
Serenity for you 
March 7, 2025 at 7:55 PM
markpitman.bsky.social
I read this daily to increase my hope. It's an uplifting poem. www.versedaily.org/2019/proclam...
www.versedaily.org
March 7, 2025 at 8:31 PM
Reposted
moorejh.bsky.social
Harnessing memetic algorithms: a practical guide link.springer.com/article/10.1... #machinelearning #datascience
Harnessing memetic algorithms: a practical guide - TOP
The aim of this work is to provide a didactic approximation to memetic algorithms (MAs) and how to apply these techniques to an optimization problem. MAs are based on the synergistic combination of id...
link.springer.com
February 6, 2025 at 2:25 PM
Reposted
ucscgenomics.bsky.social
🧠 We're doing some exciting new research on the role of metabolism in human brain development and neuropsychiatric disorders that could pave the way for innovative therapies, including dietary interventions and new drugs. This multi-UC effort is #CIRMfunded. Read more: news.ucsc.edu/2025/01/most...
New grant funds effort to uncover therapeutic targets for neuropsychiatric disorders
A $10.3 million grant from the California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency, will fund a multi-UC effort to better understand neuropsychiatric disorders.
news.ucsc.edu
February 6, 2025 at 6:22 PM
Reposted
moorejh.bsky.social
CodeCommons is an ambitious project to create the world’s most comprehensive digital commons for code codecommons.org #coding #code
January 28, 2025 at 2:12 PM
Reposted
moorejh.bsky.social
In this new paper we address how to accurately query an ontology-based knowledgebase using LLMs with RAG & dynamic graph of thoughts. Blows ChatGPT out of the water academic.oup.com/bioinformati... #bioinformatics #llms #nlp #ontologies #graphs #graphdatabase #graphofthoughts #knowledge
ESCARGOT: An AI Agent Leveraging Large Language Models, Dynamic Graph of Thoughts, and Biomedical Knowledge Graphs for Enhanced Reasoning
AbstractMotivation. LLMs like GPT-4, despite their advancements, often produce hallucinations and struggle with integrating external knowledge effectively.
academic.oup.com
January 25, 2025 at 3:07 PM
Reposted
donmoyn.bsky.social
I am begging the national media to start taking this seriously.

Stop buying the claims that the framing of "temporary" or "pause."

They are altering the review processes of federally funded scientific research from merit-based peer review processes to political screening by ideologues.
marisakabas.bsky.social Marisa Kabas @marisakabas.bsky.social · Jan 27
NEW — OMB temporarily pauses all agency grants and loans programs.

Per copy of memo: "The use of Federal resources to advance Marxist equity, transgenderism, and green new deal social engineering policies is a waste of taxpayer dollars that does not improve the day-to-day lives of those we serve."
SUBJECT: Temporary Pause of Agency Grant, Loan, and Other Financial Assistance Programs 'The American people elected Donald J. Trump to be President of the United States and gave him a mandate to increase the impact of every federal taxpayer dollar. In Fiscal Year 2024. of the nearly $10 trillion that the Federal Government spent, more than $3 trillion was Federal financial assistance, such as grants and loans. Career and political appointees in the Executive Branch have a duty to align Federal spending and action with the will of the American people as expressed through Presidential priorities. Financial assistance should be dedicated to advancing Administration priorities, focusing taxpayer dollars to advance a stronger and safer America, eliminating the financial burden of inflation for citizens, unleashing American energy and manufacturing, ending wokeness" and the weaponization of government, promoting efficiency in government, and Making America Healthy Again. The use of Federal resources to advance Marxist equity, transgenderism, and green new deal social engineering policies is a waste of taxpayer dollars that does not improve the day-to-day lives of those we serve. This memorandum requires Federal agencies to identify and review all Federal financial assistance programs and supporting activities consistent with the President's policies and requirements. For example, during the initial days of his Administration, President Donald J Trump issued a series of executive orders to protect the American people and safeguard valuable taxpayer resources, including Protecting the American People Against Invasion (Jan. 20, 2025). Reevaluating and Realigning United States Foreign Aid (Jan 20, 2025), Putting America First in International Environmental Agreements (Jan. 20, 2025). Unleashing American Energy (Jan. 20. 2025). Ending Radical and Wasteful Government DEI Programs and Preferencing (Jan. 20. ent these orders, each agency must complete a comprehensive analysis of all jal assistance programs to identify programs, projects, and activities that any of the President's executive orders. In the interian, to the extent applicable law, Federal agencies must temporarily pause all activities related disbursement of all Federal financial assistance, and other relevant agency nay be implicated by the executive orders, including, but not limited to, financial surice tot foreign nongovernmental organizations, DEL woke gender ideology, and the pause will provide the Administration time to review agency programs of the funding for those programs consistent with the law and the he temporary pause will become effective on January 28, 2025, at 5:00 rehensive analysis. Federal agencies must immediately deadlines for assistance programs arising while the les must report this information to OMB along with an directs Federal agencies to pause all activities associated conducting merit review panels No later than Febrar - 10. 2025, agencies shail submit to OMB detailed information on any programs projects or activities subject to this pause. Each agency must pause. (i) issuance of disbursement of Federal funds under all open awards, and (il) other relevant has reviewed provided guidance to your agency with respect to the information act recordin grant and ptions allowing Federal agencies to issue new awards or take other case basis. To the extent required by law, Federal agencies may continue nistrative actions. such as closeout of Federal awards (2 CFR 200.344), or expressly required by law
January 28, 2025 at 1:46 AM
Reposted
biorxiv-genomic.bsky.social
Pooled long-read sequencing for structural variant characterization in schistosome populations https://www.biorxiv.org/content/10.1101/2025.01.25.634855v1
January 28, 2025 at 1:36 AM
Reposted
astrobiology.bsky.social
Probing The Limits of Habitability: A Catalog Of Rocky Exoplanets In The Habitable Zone
astrobiology.com/2025/01/prob... #astrobiology #exoplanet #astronomy
Probing The Limits of Habitability: A Catalog Of Rocky Exoplanets In The Habitable Zone - Astrobiology
Several ground- and space-based searches have increased the number of known exoplanets to nearly 6000. While most are highly unlike our planet, the first rocky worlds in the Habitable Zone (HZ) provid...
astrobiology.com
January 27, 2025 at 5:18 PM
Reposted
qi.com
What an astonishing thing a book is. It’s a flat object made from a tree with flexible parts on which are imprinted lots of funny dark squiggles. But one glance at it and you’re inside the mind of another person, maybe somebody dead for thousands of years. CARL SAGAN
January 27, 2025 at 1:42 PM
markpitman.bsky.social
Has anyone considered that birth rate decline is simply a complex system correcting itself? The planet can only support so many people. If declining birthrates continue at current rates we'll max out at about 18 billion in 2080 and then enter steady population decline. I don't see this as a problem.
January 28, 2025 at 1:19 AM
Reposted
retroguy18.bsky.social
Haiku #1

Summersalt on grass
Over the morning spring dew
My shirt is now wet
January 23, 2025 at 5:48 PM
Reposted
astrobiology.bsky.social
The Extremophile Protein That Revolutionized DNA Sequencing
astrobiology.com/2025/01/the-... #astrobiology #extremophile #genomics #synbio
The Extremophile Protein That Revolutionized DNA Sequencing - Astrobiology
This game-changing bacterium is called Thermus aquaticus, and it can withstand temperatures as high as 80°C. It’s an example of an extremophile – an organism capable of living in extreme environments ...
astrobiology.com
January 16, 2025 at 5:02 PM
Reposted
johnhawks.net
Large parts of our genome are duplicated DNA, and variation in these parts of the genome was very hard to study until long-read sequencing. New work on these segmental duplications is adding a new dimension to human genetic diversity.

johnhawks.net/weblog/the-c...
The contribution of segmental duplications to human diversity
New studies based on long-read sequencing open a new way of looking at variation of these structural variants.
johnhawks.net
January 18, 2025 at 3:23 PM
Reposted
jamie-blundell.bsky.social
Delighted to share our latest work exploring levels of selection operating during pre-cancerous evolution usng single-cell DNA sequencing of HSCs led by the outstanding Gladys Poon
www.cell.com/cell-genomic...
Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution
The representation of driver mutations in preleukemic HSCs provides a window into the somatic evolution that precedes AML. Here, Poon et al. isolate pHSCs from the bone marrow of 16 patients with AML ...
www.cell.com
January 21, 2025 at 8:20 PM
Reposted
vickiboykis.com
just used the word agentic today without batting an eye
January 23, 2025 at 1:23 AM