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Reposted by Mathieu Lupien

Rob Klose @robklose.bsky.social · 15h

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...

John Innes Centre

jobs.jic.ac.uk

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Reposted by Mathieu Lupien

Jamie Hackett @jamiehackett.bsky.social · 11d

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

www.embopress.org

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Anna Obenauf @obenaufa.bsky.social · Sep 4

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Full Professorship in Molecular Mechanisms of Disease

The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...

www.maxperutzlabs.ac.at

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Mathieu Lupien @matlupien.bsky.social · Aug 29

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications

Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...

www.nature.com

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Reposted by Mathieu Lupien

Schubeler Lab @schubelerlab.bsky.social · Aug 7

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

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Reposted by Mathieu Lupien

10x Genomics @10xgenomics.bsky.social · Aug 7

This acquisition will bring together two pioneering companies with a shared vision: to make single cell analysis more powerful, affordable and accessible to researchers worldwide.

Learn more: bit.ly/4mAWAS8

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Mathieu Lupien @matlupien.bsky.social · Aug 6

Nicely done on the interview. Great to see your work getting the spotlight it deserves! And for those of us looking to dig into the science:

Climate change, age acceleration, and the erosion of fitness in polar bears

Climate change is increasingly disrupting evolved life history strategies and reducing population viability in wild species. Using estimates of epigenetic age acceleration, a cellular biomarker of lif...

www.biorxiv.org

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Mathieu Lupien @matlupien.bsky.social · Jul 31

One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures

Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

www.sciencedirect.com

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Mathieu Lupien @matlupien.bsky.social · Jul 30

Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.

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Mathieu Lupien @matlupien.bsky.social · Jul 30

RNA splicing involving poison exons is a whole other world, one I'm all ears to learn about.

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Mathieu Lupien @matlupien.bsky.social · Jul 30

Nice study showing how DNA mutagenesis can be driven by transcription factor (TF) competition with mismatch repair machinery: www.cell.com/cell/fulltex...
Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...

DNA mutagenesis driven by transcription factor competition with mismatch repair

Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

www.cell.com

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Mathieu Lupien @matlupien.bsky.social · Jul 30

Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.

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Reposted by Mathieu Lupien

Ian Scott @icscott.bsky.social · Jul 27

Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social).

jobs.sciencecareers.org/job/673968/p...

Program Head – Developmental, Stem Cell, and Cancer Biology - Toronto (Region), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 673968

Provide leadership and mentorship to members of the Developmental, Stem Cell & Cancer and influence the scientific direction of the Research Institute

jobs.sciencecareers.org

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Reposted by Mathieu Lupien

Mathieu Lupien @matlupien.bsky.social · Jul 23

A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU

The History and Mystery of Chromatin

YouTube video by University of New England

youtu.be

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Mathieu Lupien @matlupien.bsky.social · Jul 23

A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU

The History and Mystery of Chromatin

YouTube video by University of New England

youtu.be

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Mathieu Lupien @matlupien.bsky.social · Jul 21

Less than a month to go until the GRC on Hormone-Dependent Cancers! Looking forward to reconnecting with the community and sharing our latest on epigenomics of ecDNAs in tumor evolution. www.grc.org/hormone-depe...

2025 Hormone-Dependent Cancers Conference GRC

The 2025 Gordon Research Conference on Hormone-Dependent Cancers will be held in Newry, Maine. Apply today to reserve your spot.

www.grc.org

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Reposted by Mathieu Lupien

Fusion Conferences @fusionconf.bsky.social · Jul 17

Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov!
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp

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Mathieu Lupien @matlupien.bsky.social · Jul 16

If you're into super-resolution microscopy, check out the new story from Myles Brown's lab showing how chromatin architecture responds to hormone signaling at enhancers. Dynamic, ligand-dependent changes in H3K27ac structure with implications for endocrine resistance. www.biorxiv.org/content/10.1...

Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity

Changes in gene expression regulated by ligand-dependent transcription factors such as estrogen receptor-α (ERα) involves the recruitment of coactivators including p300 that acetylates histone H3 at l...

www.biorxiv.org

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Francis Lynn 🇨🇦 @nictitate.bsky.social · Jul 7

Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...

research.ubc.ca

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Mathieu Lupien @matlupien.bsky.social · Jul 5

My mindset is more that rather than debating with CIHR about in-person versus virtual reviews, we should unite in pushing for a higher payline.

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Norwegian Centre for Molecular Biosciences and Medicine (NCMBM) @ncmbm.bsky.social · Jun 30

📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups!

🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!

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Reposted by Mathieu Lupien

Elizabeth McKenna @elizsmckenna.bsky.social · Jul 3

The July issue of Cancer Discovery is now online! The cover features work by Alexandra Redding, Elda Grabocka, and colleagues on intercellular heterogeneity of stress granules and chemotherapy response - read that and much more here: aacrjournals.org/cancerdiscov...

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Mathieu Lupien @matlupien.bsky.social · Jul 4

Raising the payline seems better than IP meetings to improve grant review. At current levels, reviewers culture is shifted on picking one top grant from 8–10. A 25–30% payline shifts the focus to ranking the top ~3, forcing clearer justification of rank order to exclude grant 4,5 and 6.

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Cote lab-The KAT in the HAT @lab-hat.bsky.social · Jul 4

come join us in our brand new research building!
www.crc.ulaval.ca/wp-content/u...

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Mathieu Lupien @matlupien.bsky.social · Jul 4

Should TFRI consider revising their past virtual review panel decisions?

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