Matthias Krause
@matthias-krause.bsky.social
240 followers 340 following 19 posts
Cell migration and endocytosis research lab https://cytoskeleton.wixsite.com/krauselab
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matthias-krause.bsky.social
New from our lab: We identify NHSL3 as a lamellipodial Ena/VASP and Scar/WAVE complex interacting protein binding the latter with a unique mode of interaction and inhibiting Arp2/3 complex activity but unexpectantly promoting mesenchymal cell migration efficiency. www.biorxiv.org/content/10.1...
NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration
Tight control of mesenchymal cell migration is important for embryonic development and its deregulation causes disease. It is driven by lamellipodia protrusion, the leading edge of the migrating cell....
www.biorxiv.org
Reposted by Matthias Krause
ankita13jha.bsky.social
If anyone ever wants to brush up on a lot of cell migration concepts don't forget we have several wonderful scientists who have given talks previously in cell migration seminars. I find it so comforting to go look at old videos, maybe someone else who will do as well!!
youtube.com/@cellmigrati...
Cell Migration Seminars
Cell Migration Seminars every Tuesday at 16:00 BST.
youtube.com
Reposted by Matthias Krause
superresolusian.bsky.social
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
Bioimage Analysis Specialist | King's College London
www.kcl.ac.uk
Reposted by Matthias Krause
mgabrielaite.bsky.social
Next, at #EYSF2025 @reviewcommons.org is presented by @saramonaco-rc.bsky.social. It’s journal-agnostic, concentrates on science only and can save time as the peer-reviewed preprints can easily be resubmitted. How great would it be if we could ditch publishing and switch to reviewed preprints?
Reposted by Matthias Krause
samstehbens.bsky.social
I’m not sure as a community we **truely** acknowledged how powerful the #CellMigrationSeminarSeries series was at keeping us connected at such an uncertain time. Thank-you @ankita13jha.bsky.social @adamshellard.bsky.social @drjenmitchell.bsky.social & @simplythebex.bsky.social
Reposted by Matthias Krause
djcohen.bsky.social
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
Reposted by Matthias Krause
actin-paris-saclay.bsky.social
🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay!
🔬 Study cytoskeletal signaling in collective cell migration
🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France
🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...
Reposted by Matthias Krause
stramerlab.bsky.social
Drosophila as a model system to understand #collagen IV-related genetic disease. Learn how fly genetics and exploding brain tissue can inform on #ECM defects and pathological mechanisms. Team effort led by a very talented recent PhD graduate, Angus Nichols. doi.org/10.1016/j.ma...
Reposted by Matthias Krause
rupress.org
In new @jcb.org study from Muziyue Wu et al. @oweinerlab.bsky.social, in vivo biochemistry sheds new light on how the WAVE complex templates the characteristic shape of lamellipodial protrusions. rupress.org/jcb/article/...

#Cytoskeleton #Actin #Migration #Motility #Biophysics
Reposted by Matthias Krause
juanmartin-serrano.bsky.social
I am so proud of @jezcarlton.bsky.social . What a magnificent inaugural lecture, many congratulations Professor Carlton!
Reposted by Matthias Krause
anhhle2702.bsky.social
OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system.
www.science.org/doi/10.1126/...
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration
Repositioning of Rab25 vesicles containing formin and integrin cargos to the cell periphery promotes protrusion formation.
www.science.org
matthias-krause.bsky.social
Manuscript from our lab on BioRxiv: We provide mechanistic insights that NHSL1 promotes Fast endophilin mediated carrier formation via both endophilin and Ena/VASP proteins thereby may facilitate membrane bending and Ena/VASP mediated actin polymerisation. www.biorxiv.org/content/10.1...
Nance-Horan Syndrome-like 1 interacts with endophilin and Ena/VASP proteins to promote fast endophilin-mediated endocytosis
Endocytosis is crucial for various physiological processes, facilitating the uptake of membrane proteins and extracellular material. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A (EndoA), enables clathrin-independent, ligand-induced receptor uptake at the leading edge of cells. Whilst F-actin polymerisation is essential for FEME, how actin dynamics are regulated at sites of FEME is unknown. NHSL1, a member of the Nance-Horan Syndrome protein family, localises to the leading edge of cells, where it regulates migration, and to vesicular puncta, where its function is undetermined. Here, we show that NHSL1 and its uncharacterised family member NHSL2 co-localise and engage in direct, multivalent interactions with EndoA. NHSL1 also binds Ena/VASP proteins, a family of actin elongators. NHSL1 promotes FEME in cells and its interactions with EndoA and Ena/VASP proteins are required for this function. Thus, NHSL1 may cooperate with EndoA and Ena/VASP proteins to control membrane invagination and actin polymerisation, thereby mediating FEME. ### Competing Interest Statement The authors have declared no competing interest.
www.biorxiv.org
Reposted by Matthias Krause
Reposted by Matthias Krause
matthias-krause.bsky.social
New from our lab: We identify NHSL3 as a lamellipodial Ena/VASP and Scar/WAVE complex interacting protein binding the latter with a unique mode of interaction and inhibiting Arp2/3 complex activity but unexpectantly promoting mesenchymal cell migration efficiency. www.biorxiv.org/content/10.1...
NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration
Tight control of mesenchymal cell migration is important for embryonic development and its deregulation causes disease. It is driven by lamellipodia protrusion, the leading edge of the migrating cell....
www.biorxiv.org
Reposted by Matthias Krause
xaviertrepat.bsky.social
Pre-announcing the EMBO/EMBL symposium "Mechanobiology Across the Tree of Life", Heidelberg, 9-12 June 2026. It is still very very far away, but save the date 🗓️. With Alba Diz-Munoz, @nicolettapetridou.bsky.social , Kirsty Wan @micromotility.bsky.social, Enrique Rojas.
www.embl.org/about/info/c...
Mechanobiology across the tree of life
www.embl.org
Reposted by Matthias Krause
tricytomeet.bsky.social
🚨 Registration Now Open! 🚨

Join us for the 2025 Triangle Cytoskeleton Meeting on Sept. 15 at Trent Semans Center!

Speakers:
🔬 Dr. Kris DeMali
🧫 Dr. Rae Cho
🧬 Dr. Stefanie Redemann

Showcase your research, exchange ideas, and connect with the Cytoskeleton community!

Register now! 💻

#TCM2025
Reposted by Matthias Krause
felixmendu.bsky.social
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio

meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
Reposted by Matthias Krause
matthias-krause.bsky.social
New manuscript from our lab: Fast Endophilin Mediated Endocytosis (FEME), facilitates ligand induced endocytosis of a variety of receptors at the leading edge of migrating cells. The mechanism behind how FEME priming patches form is emerging.
Reposted by Matthias Krause
matthias-krause.bsky.social
Another new manuscript from our lab and excellent collaboration with the Bear lab @coronin.bsky.social: The Scar/WAVE complex promotes mesenchymal cell migration through Arp2/3 mediated lamellipodia protrusion.
matthias-krause.bsky.social
New from our lab: We identify NHSL3 as a lamellipodial Ena/VASP and Scar/WAVE complex interacting protein binding the latter with a unique mode of interaction and inhibiting Arp2/3 complex activity but unexpectantly promoting mesenchymal cell migration efficiency. www.biorxiv.org/content/10.1...
NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration
Tight control of mesenchymal cell migration is important for embryonic development and its deregulation causes disease. It is driven by lamellipodia protrusion, the leading edge of the migrating cell....
www.biorxiv.org
Reposted by Matthias Krause
robinsall.bsky.social
All three kids degreed up & off for gainful employment now...
Reposted by Matthias Krause
guijacquemet.bsky.social
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
guijacquemet.bsky.social
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
Reposted by Matthias Krause
guijacquemet.bsky.social
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!