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Anh Hoang Le, PhD 🏳️‍🌈

@anhhle2702.bsky.social

2.1K followers 1K following 190 posts

Sir Henry Wellcome fellow studying macrophage migration and mechanobiology @UCL. BSc Biochemistry @Bristol. PhD Cancer Biology @CRUK Scotland Institute. 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Cell lover by day, takeaway lover by night. https://hoanganhle2602.wixsite.com/cellsandtheirwonders

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Nov 9

My first post will be of course my proudest thing I've ever achieved. My cover image for @jcellbiol.bsky.social. It remains something I'm forever grateful and proud of.

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 4d

I said it before and I'll say it again: The whole Microsoft package Outlook, Teams, etc are literally the worst software package ever created. They give us emoji to respond, but emails would be packed into chains that are so difficult to find or even to delete. Clunky and unintuitive.

The Ass is the father of the legs @internethippo.bsky.social · 5d

"We're going to create superintelligence" How about making outlook search work first. How about that

Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · 5d

We often talk about what signals does the organiser release. But have you ever stopped and asked what does it mean to be the organiser? What cells make up the organiser? Where do they go? What do they do?
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...

Cell movements around the organizer/node after stage HH4.

Fate maps of the ectodermal (dorsal) layer of the organizer/node, based on Selleck and Stern (1991) (Selleck and Stern, 1991).

Cell movements of populations contributing to the organizer.

Stages of early chick development referred to in the text. The diagrams show some of the features used to classify the stages in relation to primitive streak formation.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Journal of Cell Biology @jcb.org · 5d

@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 6d

And we got a tree as well! A Wild cherry (Prunus avium) 🌸 So cool! Thank you to @biologists.bsky.social and @seemagrewal.bsky.social for the opportunity.
forest.biologists.com/landscape/?i...

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 6d

An essay that I wrote with 2 of my newly-met colleagues sharing our experiences attending the Immune Cell Interaction workshop in February. I'm not an immunologist by any traditional means so being given an opportunity to branch out is very much appreciated.
journals.biologists.com/jcs/article/...

Immune cell interactions in development, homeostasis and immunity

ABSTRACT. Immune cells play a fundamental role in coordinating physiological processes, from early stage development through to trained host immunity. Hence, an enhanced insight into the dynamic inter...

journals.biologists.com

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · 12d

In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · 26d

Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms.
doi.org/10.1016/j.cd...

Fig. 1. EMT dynamics in developmental models.

Fig. 2. A hypothetical model of EMT dynamics.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · 26d

Our September issue cover is now online.
You can check out the issue here:
www.sciencedirect.com/journal/cell...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

tabdanov.bsky.social @tabdanov.bsky.social · 29d

Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · Sep 5

For decades, living embryos were the favourite tool to study development. However, their complexity hindered precise dissection of many processes. This comprehensive review provides a comparison between embryos and the power of gastruloids, opening up a new wave of dev bio.
doi.org/10.1016/j.cd...

Fig. 1. Schematic overview of mouse gastrulation

Fig. 4. Different aspects of computational modelling of gastrulation.

Fig. 3. Protein localisation, cell sorting behaviours and signalling pathway activation in gastruloids. Depicted are schematic representations based on integration of existing, fragmented data. Note that there is considerable variation in gastruloid development and existing data quality and resolution, and these cartoons represent our interpretation of average domains of immunofluorescence staining.

Fig. 2. Schematic overview of signalling induced GRNs during gastrulation.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

International Society of Developmental Biology @isdb.bsky.social · Aug 29

A cryosection from an embryo stained for the neural crest (🟠) using HCR, and DAPI (⚪).
Can you guess what embryo this is?
#FluorescenceFriday
Image credit: Ines Fernandez Mosquera, PhD student at @ucl.ac.uk

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · Aug 29

Many phenotypes from cells on plastic dishes just don't seem to translate to cells in vivo, particularly isolated primary cells. @raimonsunyer.bsky.social et al discussed how cells mechanically adapt, and the different ways we can mitigate this in this very helpful review:
doi.org/10.1016/j.cd...

The molecular clutch model offers insights into how cells adapt to rigid substrates such as tissue culture polystyrene (TCPS).

Culturing cells on stiff substrates alters their mechanical phenotype. Stiff substrates, such as tissue culture polystyrene (TCPS), trigger adhesion reinforcement.

Cell selection and mechanoadaptation when isolating primary cells. This figure illustrates how primary cells isolated from a tissue explant are affected by the stiffness of the culture surface.

Strategies to mitigate stiff mechanoadaptation in cell culture.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Thibaut Brunet @thibautbrunet.bsky.social · Apr 3

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

Tissue-like multicellular development triggered by mechanical compression in archaea

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

www.science.org

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Miranda Hunter @mrndhntr.bsky.social · Aug 27

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Mechanical confinement governs phenotypic plasticity in melanoma - Nature

Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...

www.nature.com

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Lucien Hinderling @lhinderling.bsky.social · Aug 21

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

MurkyConsequences 🏳️‍🌈 @murkyconsequences.bsky.social · Aug 27

fyi, if you weren't aware

bsky.app/profile/pape...

Paper Skygest Team @paper-feed.bsky.social · Aug 19

**Please repost** If you're enjoying Paper Skygest -- our personalized feed of academic content on Bluesky -- we'd appreciate you reposting this! We’ve found that the most effective way for us to reach new users and communities is through users sharing it with their network

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 27

Fantastic! Thanks very much!

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 27

I picked up sometimes but I think the algorithm here works differently maybe. It doesnt show me the relevant papers much for some reason. And the search function is not very good.

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 27

Yet I still see many of the biggest scientists, universities, institutes still post their new research there? I barely ever find any papers to read on bluesky or is it just the algorithm works differently?

Altmetric @altmetric.com · Aug 27

Buried at the base of this @arstechnica.com article is the study itself.

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky

academic.oup.com/icb/advance-...

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 27

i wanna do it with Cyri-A vesicles 😄😄

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 27

Are you going to try it? 😄

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 27

I think, in the paper, they mention that there's no significant ice formation that affects the cell's biological activity.

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 26

YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Stand Up for Science! @standupforscience.bsky.social · Aug 21

🐤Promise you this is one you'll want to say you were a part of...

Help us get our 'ducks in a row' and IMPEACH AND REMOVE THAT DANG QUACK!!!! 📣🦆📣🦆📣🦆📣🦆

Link here: tinyurl.com/sufsci

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Matyas Bubna-Litic @matyasbl.bsky.social · Apr 11

Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'.

I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.

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