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Mike Bottery

@mbottery.bsky.social

490 followers 77 following 22 posts

Microbial Evolution - AMR - University of Manchester

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Reposted by Mike Bottery

Natalie Bennett @nataliegreenpeer.bsky.social · 22d

Currently hosting event on antifungals in medicine and agriculture, focusing on #AntiMicrobialResistance #AMR. With 6.5 million invasive infections globally each year, and 3.8 million deaths attributable to them. Area of fast-rising concern!

Graph: global incidence and mortality of sever fungal disease

Mike Bottery @mbottery.bsky.social · Sep 8

Very proud of Ed's first conference talk at #BSMM2025 did great despite the technical hiccups!!

Mike Bottery @mbottery.bsky.social · Aug 12

Thanks Ville!

Reposted by Mike Bottery

Bertuzzi Lab @bertuzzilab.bsky.social · Jul 4

Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.

Mike Bottery @mbottery.bsky.social · Jul 8

Exciting opportunities to join me in this research will be coming soon! If you're passionate about understanding microbial evolution & tackling antimicrobial resistance, keep an eye out or feel free to get in touch. 🔬🧬 🍄 #AMR #Microbiology #Evolution

Mike Bottery @mbottery.bsky.social · Jul 8

Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.

Reposted by Mike Bottery

UK Health Security Agency @ukhsa.bsky.social · Jun 4

The MHRA today released new guidance for #Phage therapy in the UK. This will provide direction for scientists and researchers working to make this treatment a reality for patients. 🔬 🧪

🔗 www.gov.uk/government/n...

Dr Colin Brown, deputy director at the UK Health Security Agency, responsible for AMR, said:

“Phage therapy truly has the potential to transform the way we treat bacterial infections, especially as resistance to antibiotics grows. At UKHSA, we’re developing new ways to help increase phage therapy use and research, including a bacteriophage collection where scientists can both access and deposit phages. In time, we hope solutions like phage therapy can become a first-line treatment option.”

Reposted by Mike Bottery

Michael Brockhurst @brockhurstlab.bsky.social · Apr 16

New preprint with nice detective work by PhD student Khadija Hanga: gain of pOXA MDR plasmid is facilitated by chromosomal mutations affecting OmpF which act synergistically with the plasmid’s carbapenamase to give high level resistance. Led by @mbottery.bsky.social www.biorxiv.org/content/10.1...

Chromosomal resistance mutations facilitate acquisition of multidrug-resistance plasmids in Escherichia coli

Bacteria can gain multiple resistance mechanisms in a single step by the acquisition of multidrug-resistance (MDR) plasmids, but it is unclear how antibiotic selection during the acquisition of MDR pl...

www.biorxiv.org

Mike Bottery @mbottery.bsky.social · Apr 1

@wellcometrust.bsky.social Thanks for organizing the ERC meeting. I found the research culture activity really helpful, so many great thought-provoking ideas

Mike Bottery @mbottery.bsky.social · Dec 19

Beautiful day to get out of the office and do some fieldwork! Soil samples + 🍄 #failsafe #mycology @normanvanrhijn.bsky.social

Mike Bottery @mbottery.bsky.social · Dec 18

Thanks Amelia!

Mike Bottery @mbottery.bsky.social · Dec 16

Sounds really exciting Bex!! I kinda miss symbionts, looking forward to hearing about you get up to

Mike Bottery @mbottery.bsky.social · Dec 16

Through the pervasive anthropogenic use of agricultural azoles, a lineage of A. fumigatus has been selected that is multi-azole resistant, multi-fungicide resistant, and also displays increased adaptability, which ultimately will lead to the evolution of a lineage that manifests pan-drug resistance.

Mike Bottery @mbottery.bsky.social · Dec 16

Here, we show that variants in the MMR gene, msh6, are almost uniquely found in strains harbouring azole resistance and result in up to 5-fold increase in mutation rates.

Mike Bottery @mbottery.bsky.social · Dec 16

Resistance to azoles is spreading most likely due to the use of agricultural fungicides. Resistance can double the risk of mortality from invasive aspergillosis.

Mike Bottery @mbottery.bsky.social · Dec 16

Only three classes of antifungal drugs available to treat disease, and only one class, the azoles, is suitable for long-term oral administration.

Mike Bottery @mbottery.bsky.social · Dec 16

The mould, found in soil, composts, and decaying vegetation, is potentially deadly to people with a range of health conditions including those with weakened immune systems and respiratory problems.

Mike Bottery @mbottery.bsky.social · Dec 16

New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system rdcu.be/d3Iyc @natureportfolio.bsky.social #microsky #fungi #amr

Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance

Nature Communications - Here, Bottery et al show that resistance to next generation antifungals is more likely to occur within azole resistant Aspergillus fumigatus due to the close linkage between...

Reposted by Mike Bottery

Michael Brockhurst @brockhurstlab.bsky.social · Dec 4

In case you missed it: @matthewjshepherd.bsky.social surveyed the clinical literature to reveal how #AMR evolves within patients, why eco/evo mechanisms vary among infections, & what we can do better to improve treatments www.nature.com/articles/s41... #MicroSky

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance - Nature Reviews Microbiology

In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence i...

Mike Bottery @mbottery.bsky.social · Dec 3

It was great fun to be part of this project! Super cool to see Rock-Paper-Scissors dynamics in real microbial populations

Jamie Hall @jpjhall.bsky.social · Dec 3

🆕New in @plosbiology.bsky.social: we show compensatory mutations make plasmids play Rock-Paper-Scissors and turn conjugation into a weapon🛡️💫✂️🦠

w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky

A chromosomal mutation is superior to a plasmid-encoded mutation for plasmid fitness cost compensation

Plasmids spread important traits in microbiomes but impose fitness costs on their hosts. This study of the ecological consequences of plasmid-bacterial compensatory evolution reveals benefits to bacte...

journals.plos.org

Mike Bottery @mbottery.bsky.social · Nov 28

PhD studentship alert!

Fully funded, co-supervised with @rokkrasovec.bsky.social and Prof Mike Bromley, University of Manchester

Exploring routes of horizontal gene transfer in pathogenic fungi

Exciting project, will be a bunch of fun! Come & join us 🔬

www.findaphd.com/phds/project...

www.findaphd.com

Reposted by Mike Bottery

Chris Knight @knightjar.bsky.social · Nov 27

Soil microbiomes show consistent and predictable responses to extreme events
We’re out in Nature !! doi.org/ntzk Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by @frantecol.bsky.social

Soil microbiomes show consistent and predictable responses to extreme events - Nature

Soils from 30 grasslands across Europe were subjected to 4 contrasting extreme climatic events under drought, flood, freezing and heat conditions, with the results suggesting that soil microbiomes fro...

Mike Bottery @mbottery.bsky.social · Nov 23

Fungal Genetics Stock Centre, there's something fishy going on here...

Mike Bottery @mbottery.bsky.social · Nov 21

It was a pleasure to have the opportunity to present our work!

Prof Paula Salgado @pssalgado.bsky.social · Nov 21

We now have Michael Bottery from Manchester Univ on his work on #AMR in Aspergillus fumigatus #WAAW #microSky

Mike Bottery @mbottery.bsky.social · Nov 21

Sorry I don't think it's being recorded!