Lightnews — Scholar-powered news

Reposted by Cameron McAlpine

NY-CURES @nycures.bsky.social · Sep 4

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

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Eric Topol @erictopol.bsky.social · Sep 4

New @science.org
A peptide released from white blood cells, directed against bacteria, can also poke holes in the membrane of heart muscle cells and induce a lethal arrhythmia (ventricular tachycardia). In the mouse model.
www.science.org/doi/10.1126/...

Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia

Ventricular tachycardia disrupts the heart’s coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrh...

www.science.org

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Cameron McAlpine @mcalpinelab.bsky.social · Aug 31

It was a pleasure to present data from the lab at #ESCcongress! There has been a great focus on neuronal and immune contributions to CVD.

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Cameron McAlpine @mcalpinelab.bsky.social · Aug 12

I am honored to receive this award! It is a testament to the lab and their hard work!

The Friedman Brain Institute @sinaibrain.bsky.social · Aug 12

✨CONGRATULATIONS @mcalpinelab.bsky.social on being honored w/ the Dr. Harold & Golden Lamport Basic Research Award for demonstrating exceptional promise for making significant, long-term contributions to biomedical research!🎉
@mountsinainyc.bsky.social @sinaiimmuno.bsky.social

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Erin Gibson @erinmgibson.bsky.social · Jul 16

www.nature.com/articles/s41...

Mitochondrial origins of the pressure to sleep - Nature

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

www.nature.com

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David Sancho @sancholab.bsky.social · Jul 16

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

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The Friedman Brain Institute @sinaibrain.bsky.social · Jul 8

What happens in Vagus🎰... find out on July 29th at 10am when you join host Dr. Sarah Stanley as she welcomes University of Virginia's Dr. John Campbell @augcsoup.bsky.social to the #BrainBodyResearchInstitute Seminar Series @mountsinainyc.bsky.social. Register👉 mountsinai.zoom.us/webinar/regi...

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Cameron McAlpine @mcalpinelab.bsky.social · Jul 3

Very much looking forward to having Tim as a colleague and lab neighbor! Many exciting collaborations to come!

Tim Kenny @timckenny.bsky.social · Jul 3

Thrilled to announce that I will be joining the @mountsinaicvri.bsky.social at the Icahn School of Medicine at Mount Sinai as an Assistant Professor in January! My laboratory will focus on nutrient transport and cellular metabolism in physiology and disease.

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John Lukens @lukensjohnr.bsky.social · Jun 24

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
www.nature.com/articles/s41...

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia - Nature Immunology

McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.

www.nature.com

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The Cardiovascular Research Institute at Mount Sinai @mountsinaicvri.bsky.social · Jun 23

We are proud to announce that five CVRI faculty members - Fil Swirski (@filswirski.bsky.social), Mandy van Leent, Cameron McAlpine (@mcalpinelab.bsky.social), Maria Noval, and Sikander Hayat - will be presenting their groundbreaking work at Atherosclerosis GRC this Friday, June 27th.

2025 Atherosclerosis Conference GRC

The 2025 Gordon Research Conference on Atherosclerosis will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

www.grc.org

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Cameron McAlpine @mcalpinelab.bsky.social · May 22

Check out our review on neural mechanisms in cardiovascular health and disease! 👇

Fil Swirski @filswirski.bsky.social · May 22

Happy to share a new review:

Neural Mechanisms in Cardiovascular Health and Disease | Circulation Research www.ahajournals.org/doi/full/10....

Part of a series on Inter-organ communication!

Great teamwork: KA Ziegler, S Engelhardt, D Carnevale, C McAlpine, T Guzik, S Dimmeler!

Neural Mechanisms in Cardiovascular Health and Disease | Circulation Research

Although the neurocardiac axis is central to cardiovascular homeostasis, its dysregulation drives heart failure and cardiometabolic diseases. This review examines the bidirectional interplay between t...

www.ahajournals.org

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Cameron McAlpine @mcalpinelab.bsky.social · May 22

A wonderful perspective that includes the idea of cardiovascular disease as a stressor that induces sleep.

Eric Topol @erictopol.bsky.social · May 22

Experimental evidence that post-stress sleep has the capacity to build resilience

cell.com/neuron/fullt...

Sleep and the recovery from stress

Stress often causes insomnia, yet certain stressors, including illness and psychosocial events, can induce sleep. Yu et al. propose that post-stress sleep contributes to resilience and discuss potenti...

cell.com

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Cameron McAlpine @mcalpinelab.bsky.social · May 19

We are looking for a scientist to join the growing Brain-Body Research Institute at Mount Sinai! Consider joining a dynamic fundamental and translational team investigating inter-organ physiology and communication between the brain and periphery. Feel free to reach out if you have any questions.

Scott Russo @scottrussophd.bsky.social · May 14

The Brain-Body Research Institute @IcahnMountSinai is hiring an Associate Director to build clinical and translational research in brain-body sciences. See ad here: neuroscience.mssm.edu/pdf/Brain-Bo.... @sinaibrain.bsky.social @sinaiimmuno.bsky.social @brainbodylab.bsky.social

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Eric Topol @erictopol.bsky.social · May 15

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...

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JACC Journals @jaccjournals.bsky.social · May 5

Exciting news! 🎉

Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.

Please join us in welcoming him to this important role 👏👏 👏

📎: www.jacc.org/announcement...

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aaron-douglas.bsky.social @aaron-douglas.bsky.social · Apr 24

Very excited to share part of my postdoctoral work from the @tjryan.bsky.social lab, out now in @nature.com. Here, my brilliant co-author @andreamunozz.bsky.social and I explored the link between memory engrams and whole-body metabolism.

A thread: 🧵

www.nature.com/articles/s41...

Cold memories control whole-body thermoregulatory responses - Nature

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...

www.nature.com

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Cameron McAlpine @mcalpinelab.bsky.social · Apr 17

We are thrilled to share the latest from the lab! We demonstrate that multi-organ MCSF-dependent myelopoiesis is dynamic in MS and is manipulated by lifestyle to influence disease severity and neuroinflammation. Big congrats to the whole team!
www.nature.com/articles/s41...

Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis - Nature Communications

Myeloid cells contribute to the etiology of multiple sclerosis (MS), but the dynamics of myelopoiesis during disease progression is still unclear. Here the authors show, in both mouse models and clini...

www.nature.com

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Michael Grandner @grandner.bsky.social · Apr 15

Excited to announce an official scientific statement from the @americanheart.bsky.social!

"Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health"

Special thanks to @m-pst-ongephd.bsky.social

www.ahajournals.org/doi/10.1161/...

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The Friedman Brain Institute @sinaibrain.bsky.social · Mar 24

A Huge Congratulations to @scottrussophd.bsky.social 👉 named Director of the NEW #BrainBody Research Institute. The Institute will focus on holistic approaches to science & medicine to gain a better understanding of how the brain & body interact in health & disease. Again, Congratulations Scott!👏💯

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Edelblum Lab @edelblumlab.bsky.social · Mar 21

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

www.science.org

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Eric Topol @erictopol.bsky.social · Mar 5

Sleep duration/timing and glucose regulation in over 1100 people with 14-day continuous glucose sensor
jamanetwork.com/journals/jam...

Sleep and Long-Term Risk of Type 2 Diabetes in Women With Gestational Diabetes

This cohort study assesses whether sleep duration and quality are associated with incidence of type 2 diabetes among women with a history of gestational diabetes who participated in the Nurses’ Health...

jamanetwork.com

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Waggoner Lab @labwaggoner.bsky.social · Feb 26

Better sleep quality could reduce inflammation and improve health outcomes in obesity
doi.org/10.1093/jimm...
@jimmunol.bsky.social

Impact of sleep deprivation on monocyte subclasses and function

Abstract. The relationship between sleep deprivation, obesity, and systemic inflammation is a critical area of investigation due to its significant impact

doi.org

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Scott Russo @scottrussophd.bsky.social · Feb 12

1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in
shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social

Read it here: www.nature.com/articles/s41...

A crucial role for the cortical amygdala in shaping social encounters - Nature

The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.

www.nature.com

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Cameron McAlpine @mcalpinelab.bsky.social · Dec 17

Check out this beautiful image called "Sleepy Aorta" from Jake, a student in the lab! This is an immunofluorescent image of atherosclerosis in the aortic root of a mouse with poor sleep. Give the post a ❤️ to vote for the #ArtoftheBrain contest! ❤️↔️🧠

The Friedman Brain Institute @sinaibrain.bsky.social · Dec 17

How important is it to get enough sleep? In the McAlpine Lab's Walter Jacob's image "Sleepy Aorta", immunofluorescence staining captures the immense cardiovascular inflammation following months of poor sleep. @mcalpinelab.bsky.social VOTE NOW for #ArtoftheBrain Image #3 👉 Most 💚's wins!

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Nicholas A. Christakis @nachristakis.bsky.social · Nov 19

In medical school in the 1980s, we were taught that depression was an unpleasant and unwanted side effect of having a heart attack. But what if it is a healthy physiological response to help you heal by lowering demand on your heart? www.nature.com/articles/s41... | @natureportfolio.bsky.social

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

www.nature.com

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