John Clarke, Michel Devoret and John Martinis discovered quantum physics on a macroscopic scale, paving the way for quantum computing.

Cholesterol attenuates progesterone signaling through competitive binding of progesterone receptors.

This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

Super-resolution imaging detects plasma membrane domains that emerge when receptors are clustered in live B cells. Domain structures arise due to the membrane phase transition and can tune local membrane organization and receptor activation.

I explain the history and significance of a new theoretical framework for membrane biology that challenges previous ways of thinking.

The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...