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Reposted by Mads Gabrielsen

Science News @scinews.bsky.social · Sep 7

Why would anyone want to be a scientist?

"Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection."

journals.biologists.com/jcs/article/...

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Mads Gabrielsen @mgabro.bsky.social · Aug 10

My latest paper has been accepted in @lsajournal.org. Thanks to Mark Nakasone and Lori Buetow for all their efforts. @mvls-srf.bsky.social

doi.org/10.26508/lsa...

Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue

RING family ubiquitin ligases (E3s) employ the RING domain to recruit the E2 thioester ubiquitin (E2∼Ub) intermediate to catalyze the transfer of ubiquitin (Ub) to substrates. A cationic Arg linchpin ...

doi.org

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Reposted by Mads Gabrielsen

MVLS Shared Research Facilities @mvls-srf.bsky.social · Aug 6

Join our hands-on 4-day workshop and master the art of expressing & purifying proteins in E. coli!
Learn:
- Construct design
- Overexpression
- Chromatography
- SDS-PAGE & spectrophotometry
All lab materials provided!
www.gla.ac.uk/colleges/mvl...

Poster for a Protein Production and Purification Workshop, text displayed in a blue circle. Featuring:
Construct design for successful purification
Overexpression strategies
Chromatography with AKTA systems
SDS-PAGE & spectrophotometry analysis

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Mads Gabrielsen @mgabro.bsky.social · Jul 15

Well deserved Evangelos

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Mads Gabrielsen @mgabro.bsky.social · Jul 9

This is one of the best science fiction /fantasy works I have read. It was like being punched in the guts.

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Reposted by Mads Gabrielsen

Kate Michie @kmichie.bsky.social · Jul 7

🤩🪩🕺

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · Jul 7

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco

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Mads Gabrielsen @mgabro.bsky.social · Jun 30

Very pleased to have been involved with this work, and I think it highlights the power of SAXS when combined with Alphafold predictions. @mvls-srf.bsky.social

Journal of Cell Biology @jcb.org · Jun 27

The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social‬ identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...

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Reposted by Mads Gabrielsen

Helen Walden @hw1o9.bsky.social · Jun 27

It’s too late on a Friday night for me to post sensibly about this work! But I’m super proud of Joanna’s determination to validate Parkin substrates and I love working with her robust and creative science!

Journal of Cell Biology @jcb.org · Jun 27

The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social‬ identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...

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Reposted by Mads Gabrielsen

Dave nλ=2dsinθ @xtaldave.xtaldave.net.ap.brid.gy · Jun 20

Protect transgender scientists | Science
🏳️‍⚧️ :science:

https://www.science.org/doi/10.1126/science.ady0962

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Reposted by Mads Gabrielsen

MVLS Shared Research Facilities @mvls-srf.bsky.social · Jun 20

This is sure to be a brilliant day, we are looking forward to getting involved!

University of Glasgow @uofglasgow.bsky.social · Jun 20

Join @uofgmvls.bsky.social for Life Sciences Partnerships Day 2025!

🗓️ 1 Oct at
@UofGARC

Meet researchers, partners, funders and hear a keynote from Astra Zeneca. Stay on a drinks reception to round off the day!

Register now: buff.ly/OxMhJRF

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Reposted by Mads Gabrielsen

Johanna Bischof @jojobischof.bsky.social · Jun 5

Interesting webinar for Core Facility folks - advocating for CFs, future-proofing, and navigating impact of outside challenges on the facility.
Join this webinar and opportunity for exchange on June 16th.

Royal Microscopical Society @royalmicrosoc.bsky.social · May 27

📢Navigating Strategies for Core Facilities 2025: A Town Hall Webinar (16 June, 5-8pm BST)

Don't miss this *free*, interactive webinar to help shape the future of core facilities! 🔬

Join the discussion - all are welcome😀
#imaging #microscopy

rms.org.uk/rms-event-ca...

@rmsearlycareer.bsky.social

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Reposted by Mads Gabrielsen

Nathan Woodling @nathanwoodling.bsky.social · Jun 1

We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).

Header with images of cultured cells and a Drosophila brain. Text below reads:

We are excited to be recruiting our team of 3 post-doctoral research fellows to study the mechanisms underlying ageing-dependent glial cell dysfunction and its effects on neurodegeneration! This is a three-year Medical Research Council-funded cross-disciplinary, multi-partner project with one post-doctoral fellow at each site: Edinburgh Napier, University of Glasgow, and UCL. If you are interested in glial cell biology/neurodegeneration, functional genomics and bioinformatics please get in touch or apply below: Astrocyte ageing & Bioinformatics: Fiona Kerr, ENU (f.kerr@napier.ac.uk): Apply here: Closing Date: https://jobs.napier.ac.uk/mthrprod_webrecruitment/wrd/run/etrec179gf.open?WVID=150547JMmr&LANG=USA Tuesday 24th June 2025 Microglial Ageing & Bioinformatics: Dervis Salih, UCL (dervis.salih@ucl.ac.uk): Apply here: https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?jobId=35013&jobTitle=Research+Fellow Closing Date: Thursday 26th June 2025
Drosophila models of neurodegeneration: Nathan Woodling, University of Glasgow (nathan.woodling@glasgow.ac.uk): Apply here: https://www.jobs.gla.ac.uk/job/research-associate-49?source=gla.ac.uk Closing Date: Wednesday 25th June 2025

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Reposted by Mads Gabrielsen

Carsten Schulte @carstenschulte4.bsky.social · May 30

#Science Bluesky, do your thing:
We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas.
Can you indicate some names to me?

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Mads Gabrielsen @mgabro.bsky.social · May 28

Spent the afternoon talking to colleagues from @uofglasgow.bsky.social and @glasgowcaledonian.bsky.social about research strategies.

Reposted by Mads Gabrielsen

MVLS Shared Research Facilities @mvls-srf.bsky.social · May 27

@lemgruber.bsky.social presenting at the Technical Showcase!

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Reposted by Mads Gabrielsen

MVLS Shared Research Facilities @mvls-srf.bsky.social · May 27

Had a great day with @uofgengineering.bsky.social and @uofgchem.bsky.social! Showcasing our technical expertise and having some fantastic conversations! @uofglasgow.bsky.social

Photograph of people having a conversation about brilliant science at an exhibition table.

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Mads Gabrielsen @mgabro.bsky.social · May 27

Good day at the CoSE / MVLS SRF showcase today

MVLS Shared Research Facilities @mvls-srf.bsky.social · May 27

@mgabro.bsky.social presenting at the Technical Showcase!

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Reposted by Mads Gabrielsen

MVLS Shared Research Facilities @mvls-srf.bsky.social · May 16

Got questions about protein production or structural biology?
Swing by the Drop-in Clinic in the WWCRC! Get expert advice on:
- Construct design & purification
- Crystallography, NMR, SAXS & more
📅 Friday 30th May from 1200
@uofgcancersciences.bsky.social @sbohvm.gla.ac.uk @cvrinfo.bsky.social

Poster for a Drop-in Clinic with the following information:
Friday 30th May 1200-1600
Room 142 (inside Admin office)
Wolfson Wohl Cancer Research Centre
Garscube campus

Discuss your current and future projects.
See how the NBIPA can help your research.
Let us know what you wish you had access to.

Protein production:
Advice on construct design
Bespoke expression systems
Design of purification protocols
Access to equipment and columns, including AKTA Micro and LPS free systems

Quality assurance:
Confirm protein size
Confirm protein fold
Confirm homogeneity

Structural biology:
Structural analysis of predictions
X-ray crystallography
NMR
Small-angle X-ray scattering
Analytical ultracentrifugation

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Reposted by Mads Gabrielsen

MVLS Shared Research Facilities @mvls-srf.bsky.social · May 14

We are joining forces with Colleagues from @uofgengineering.bsky.social @uofgchem.bsky.social to present a Technical Showcase! Drop in for a chat, a flash talk or a demo to discover how our technical expertise can support your research!

Poster showing circular lights against a glass ceiling. Poster reads: Technical Showcase Tuesday 27th May. Advanced Research Centre Atrium, 10am - 3pm

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Mads Gabrielsen @mgabro.bsky.social · Apr 13

As always, great work from the Roe lab

Professor Andrew J Roe @drandyjroe.bsky.social · Apr 1

New paper from the group - here we show that aurodox prevents shiga toxin mediated damage in a murine model. Interesting changes to the microbiota too. Amazing work by @rebeccamchugh.bsky.social and the group.

Paper here- rdcu.be/efW0K

Reposted by Mads Gabrielsen

Rucha Karnik @ruchakarnik.bsky.social · Feb 24

Join us @uofgmvls.bsky.social @mvls-srf.bsky.social @mgabro.bsky.social @karniklab.bsky.social
plantscienceglasgow.org

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Mads Gabrielsen @mgabro.bsky.social · Jan 21

My university still claim it gives us the best “outreach”. How about yours?

Reposted by Mads Gabrielsen

KarnikLab @karniklab.bsky.social · Jan 11

Just a wee reminder that a fully funded PhD position working with us open for applications from plant science enthusiasts 🌱 informal inquiries to @ruchakarnik.bsky.social

www.findaphd.com/phds/project...

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Reposted by Mads Gabrielsen

Kate Beckham @kshbeckham.bsky.social · Jan 6

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239

PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com

PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com

www.findaphd.com

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