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Reposted by Michael Ward

Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 21

👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes

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Reposted by Michael Ward

Journal of Cell Biology @jcb.org · Aug 8

Hasegawa-Ogawa, Okano et al. identify a dominant-negative TDP-43 isoform regulated by #ALS-linked #RNA-binding proteins. hnRNP K promotes its expression, while hnRNP A1 and FUS suppress it. rupress.org/jcb/article/...

#Disease #Neuroscience #ProteinHomeostasis #RNAbiology

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Reposted by Michael Ward

Camp Lab @graycamplab.bsky.social · Jul 11

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

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Michael Ward @michael-e-ward.bsky.social · Jun 13

www.cell.com/cell/abstrac...

Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue

Pairing imaging and sequencing to simultaneously measure gene expression and morphological phenotypes in diverse genetically perturbed cells in mosaic animals, Perturb-Multimodal enables systematic ex...

www.cell.com

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Reposted by Michael Ward

Nature @nature.com · Jun 4

Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes

https://go.nature.com/3Z6mJ1X

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

go.nature.com

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Michael Ward @michael-e-ward.bsky.social · May 21

Thanks for hosting me - so much fun to meet with everybody at Berkeley!

Roberto Zoncu Lab @robzonculab.bsky.social · May 20

Fantastic MTx-Neuro seminar by Michael Ward @michael-e-ward.bsky.social, incredible science and full house! @mti-ucb.bsky.social

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Reposted by Michael Ward

Mark Histed @markhisted.org · May 15

Despite some ups and downs at NIH, we do have an open position for a postbac and are considering candidates.
Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪

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Michael Ward @michael-e-ward.bsky.social · May 15

www.nature.com/articles/s41...

Multimodal cell maps as a foundation for structural and functional genomics - Nature

A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paed...

www.nature.com

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Reposted by Michael Ward

Ricardo Henriques @henriqueslab.bsky.social · Apr 10

Why do lower-resolution images sometimes yield better results in deep learning for bioimaging analyses? 🤔📉

Mariana Ferreira's new preprint on #ReScale4DL explores this paradox and introduces optimal resolution design! @gomez-mariscal.bsky.social brainchild🧑‍🔬✨

Check: www.biorxiv.org/content/10.1...

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Michael Ward @michael-e-ward.bsky.social · May 5

talkingpointsmemo.com/edblog/the-w...

Not nearly enough coverage of this possibility by traditional media.

The White House’s Next Orchestrated Budget Crisis

This is something I’m still trying to get my head around –...

talkingpointsmemo.com

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Reposted by Michael Ward

Keystone Symposia @keystonesymposia.bsky.social · Apr 30

Explore #Neurodegeneration and Neural-Immune Interactions, June 8-11! Gain insights from experts like @dulaclab.bsky.social and @weissmanlab.bsky.social. Register now to save $200. Postdocs, enjoy an extra $275 off: hubs.la/Q035NHGV0

#KSNeuroImmune25 #KSNeuroDegen25 @michael-e-ward.bsky.social

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Reposted by Michael Ward

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · May 3

LRP10 promotes trafficking of progranulin and prosaposin to lysosomes https://www.biorxiv.org/content/10.1101/2025.05.02.651888v1

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Michael Ward @michael-e-ward.bsky.social · May 3

It is potentially even (much, much) worse than that…

donmoynihan.substack.com/p/the-nih-bu...

The NIH budget is on a fast track to disaster

An NIH insider explains what Republicans are likely to do next, and what we can do

donmoynihan.substack.com

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Reposted by Michael Ward

Alt NIH Bluesky 🧪 @altnih4science.bsky.social · Apr 28

Important!! 🚨

“Using the rescission process, which requires only a simple majority in the Senate, the Republican majorities can vote to return the unspent funds. That will lop billions off the NIH budget.” 1/2

Don Moynihan @donmoyn.bsky.social · Apr 28

New at Can We Still Govern: An anonymous NIH employee maps out the GOP budget gameplan to permanently gut our most important science agency.
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...

The NIH budget is on a fast track to disaster

An NIH insider explains what Republicans are likely to do next, and what we can do

donmoynihan.substack.com

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Reposted by Michael Ward

Don Moynihan @donmoyn.bsky.social · Apr 28

New at Can We Still Govern: An anonymous NIH employee maps out the GOP budget gameplan to permanently gut our most important science agency.
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...

The NIH budget is on a fast track to disaster

An NIH insider explains what Republicans are likely to do next, and what we can do

donmoynihan.substack.com

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Reposted by Michael Ward

Mark Histed @markhisted.org · Apr 23

#neuroai #neuroskyence 🧪 #ai

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Michael Ward @michael-e-ward.bsky.social · Apr 21

www.biorxiv.org/content/10.1...

Genome-wide mapping of mesoscale neuronal RNA organization and condensation

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

www.biorxiv.org

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Michael Ward @michael-e-ward.bsky.social · Apr 20

www.nature.com/articles/s41...

Multimodal cell maps as a foundation for structural and functional genomics - Nature

A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paed...

www.nature.com

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Michael Ward @michael-e-ward.bsky.social · Apr 16

Amazing team science effort, led by Marius Wernig’s group, to develop a silencing-resistant transgene cassette that maintains expression following iPSC differentiation. This was major barrier for iPSC-based experiments. Thanks to CZI for funding the research!

www.biorxiv.org/content/10.1...

Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation

While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...

www.biorxiv.org

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Reposted by Michael Ward

Takeshi Uenaka @tuenaka.bsky.social · Apr 15

Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭

So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.

Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...

Supported by @cziscience.bsky.social

Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation

While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...

www.biorxiv.org

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Reposted by Michael Ward

Juan S. Bonifacino @juanbonifacino.bsky.social · Apr 13

Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!

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Michael Ward @michael-e-ward.bsky.social · Apr 14

www.science.org/doi/10.1126/...

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

www.science.org

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Reposted by Michael Ward

Total Internal Reflection🇬🇧🇺🇸🇺🇦 @tirscienceblog.bsky.social · Apr 3

I’ve always liked Tom Pollard’s framing of biological research: genetics gives you the parts list, biochemistry the functions/reactions and rates, cell biology the localisations and dynamics, and structural biology the fine detail. Put it all together and you get a mechanistic picture. 🤩

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Michael Ward @michael-e-ward.bsky.social · Apr 2

Nailed it!

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Reposted by Michael Ward

Polymenidou Lab @polylab.bsky.social · Mar 28

Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...

Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures

TDP-43 pathology characterizes neurodegenerative diseases. Scialò et al. use in vitro-generated and patient-derived TDP-43 aggregates as seeds to show that seed-induced TDP-43 cytoplasmic aggregation ...

www.cell.com

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