The drug lenacapavir will be distributed to Eswatini and Zambia — the first step toward providing at least 2 million doses to the countries with the highest HIV burden, largely in Africa, by 2028.

Administration officials say South Africa has “significant means” to fund a promising new drug, lenacapavir, on its own. Critics call the move self-defeating.

To assess the efficacy and tolerability of Helicobacter pylori first-line treatment (omeprazole–clarithromycin–metronidazole) and second-line rescue o…

Distribution of metronidazole in the body #metronidazole #pharmacology #therapy #metabolism

Klebsiella pneumoniae, a notorious Gram-negative bacterium, presents a significant challenge in healthcare environments due to its role as an opportunistic pathogen. It is responsible for a variety of serious infections including pneumonia, urinary tract infections, and septicemia. Recently, the rise of antimicrobial resistance has exacerbated the threat posed by this organism, limiting the effectiveness of conventional treatment regimens. As a direct consequence of the extensive use of antibiotics such as aminoglycosides, quinolones, and β-lactams, we have witnessed a disturbing trend of increased resistance in K.

For decades, prolonged courses of systemic antibiotics have been standard practice after surgery for orthopaedic infections—osteomyelitis, prosthetic joint infection, fracture-related infection, and yes, even diabetic foot infections. The reasoning was simple: biofilm is hard to reach, and more antibiotics must be better than less. But what if, with the right local antibiotic strategy, less really is more? The Study The…

AbstractBackground. Although recent guidance recommends early surgical debridement for native joint septic arthritis (NJSA), supporting data, particularly

Staphylococcus aureus bacteremia (SAB) has an estimated mortality rate ranging from 5 to 20% [1]. Such mortality is partly attributable to severe complications, such as infective endocarditis (IE), wh...

AbstractPreservation and augmentation of existing antimicrobials is crucial in combating antimicrobial resistance. Gram-positive bacteria, exemplified by Staphylococcus aureus, are among the most common human bacterial pathogens, with methicillin-resistant S. aureus (MRSA) now established globally. Daptomycin is a last-line anti-staphylococcal antimicrobial that uniquely targets the bacterial membrane with bactericidal effects. Here, we developed lipid-based nanoparticles, namely cubosomes, to encapsulate daptomycin for targeted delivery via lipid-mediated interactions. Daptomycin-loaded cubosomes synergistically killed 14 clinical MRSA isolates in vitro compared with daptomycin or cubosomes alone. This synergy between daptomycin and cubosome was mediated by cubosomes docking on the S. aureus cell surface, releasing daptomycin for membrane extraction and penetration, followed by lipid cubosome infusion into S. aureus membranes. Using a murine septicemia model, daptomycin-loaded cubosomes significantly reduced the organ bacterial burden of MRSA. Together, these data showed that multifunctional lipid nanocarriers can potentiate the bactericidal activity of daptomycin using a membrane-targeted trojan-horse-like mechanism.

Hospital acquired pneumonia (HAP) still fails to respond to standard antibiotic regimens in roughly one third of cases and remains a major cause of death in intensive care. A new paper in Intensive Ca...

Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

Varón de 5 años que ingresó con estatus epiléptico en contexto de fiebre, con mala respuesta a tratamiento antiepiléptico y precisando intubación orotraqueal. En analítica de sangre presentaba 7.530 leucocitos por mm3 con 75% neutrófilos y PCR 2.6 mg/dl. El TAC y resonancia magnética cerebrales fueron normales. En radiografía de tórax se evidenciaron infiltrados neumónicos bilaterales que progresaron a pesar de antibioterapia.

Efflux of antibiotics is a survival strategy in bacteria. Mycobacterium tuberculosis has approximate

Officials confirm tuberculosis case in Charlotte-Mecklenburg school district — here's everything you need to know about TB.

The Inuulitsivik Health Centre, which provides services to Nunavimmiut on the Hudson Bay coast, said it will be setting up mobile clinics in Inukjuak from Nov. 3 to Nov. 28. After that, IHC said each ...

University of Illinois at Urbana-Champaign researchers have developed a CRISPR-based diagnostic tool capable of detecting bloodstream infections in minutes without the need for nucleic acid amplificat...