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Marie K Holt @mkbholt.bsky.social · 6d

Such a creative approach!

Sahib Khalsa @skhalsa.bsky.social · 16d

Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵

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Reposted by Marie K Holt

Ardem Patapoutian @ardemp.bskyverified.social · 20d

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...

PIEZO channels link mechanical forces to uterine contractions in parturition

Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...

www.biorxiv.org

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Reposted by Marie K Holt

Nils Kroemer @nbkroemer.bsky.social · Sep 8

When we encounter the same reward repeatedly, we show variable responses; is this just noise?
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...

The figure depicts the study rationale and procedures. We anticipated differences in reward sensitivity across groups varying in symptoms of binge eating, specifically in the variability.

Patients with binge eating disorder (BED) have a higher variability in food wanting ratings during the effort allocation task in the behavioral session.

Participants with a higher body mass index (BMI) show elevated variability of anticipatory cue responses in the nucleus accumbens (NAcc).

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Reposted by Marie K Holt

Aidan Horner @aidanhorner.bsky.social · Jul 21

2 Lecturer (Assistant Prof) positions available @yorkpsychology.bsky.social! Come join our department!

#neuroskyence #cognition #psychscisky #neurojobs

jobs.york.ac.uk/vacancy/lect...

Jobs - The University of York

jobs.york.ac.uk

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Reposted by Marie K Holt

Micah G. Allen @micahgallen.com · Aug 27

Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇

Interoceptive Ability is Unrelated to Mental Health Symptoms: Evidence From a Large Scale Multi-Domain Psychophysical Investigation

Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...

www.medrxiv.org

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Reposted by Marie K Holt

Micah G. Allen @micahgallen.com · Aug 28

the tldr of my thread is that, interoceptive sensing at rest has no relationship to mental health symptoms, and we think this is likely because we need to measure interoception during and after arousal, close in time to symptoms, with ecological measures.

Micah G. Allen @micahgallen.com · Aug 27

Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇

Interoceptive Ability is Unrelated to Mental Health Symptoms: Evidence From a Large Scale Multi-Domain Psychophysical Investigation

Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...

www.medrxiv.org

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Reposted by Marie K Holt

Nicolas Chiaruttini @nkiaru.bsky.social · Jul 24

Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:

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Reposted by Marie K Holt

Micah G. Allen @micahgallen.com · Jul 13

Modern theories of emotion (especially “interoceptive inference”) often cite William James as a key inspiration. But what did James actually say about emotion, and is it supported by the data? Here’s a brief look at the core arguments and classic evidence. 🧵

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Reposted by Marie K Holt

Jamie Hanson @jamielarsh.bsky.social · Jun 26

Gut microbiome is associated with insula structure in neonates www.sciencedirect.com/science/arti...

Gut microbiome is associated with insula structure in neonates

The infant brain and gut microbiome both develop rapidly in early infancy. Growing evidence indicates that the gut microbiome plays a critical role in…

www.sciencedirect.com

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Marie K Holt @mkbholt.bsky.social · Jun 26

First go at expansion microscopy (bar the one time we accidentally washed the tissue down the sink...) and look at that neuron!😍

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Reposted by Marie K Holt

Eric Topol @erictopol.bsky.social · Jun 25

How nerve cells transfer their powerhouse mitochondria to fuel cancer cells @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...

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Marie K Holt @mkbholt.bsky.social · Jun 23

Still a week to go to apply for our open position in Mammalian Neuroscience at University of Warwick!

Marie K Holt @mkbholt.bsky.social · Jun 16

Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩‍🔬👨‍🔬

My department is hiring! Closing on June 30th.

Please repost widely!

www.jobs.ac.uk/job/DNK944/a...

Assistant or Associate Professor in Mammalian Neuroscience (110565-0625) at University of Warwick

Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

www.jobs.ac.uk

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Reposted by Marie K Holt

Zane Andrews @zane-andrews.bsky.social · Jun 19

We created a photometry python package for unbiased standardised post-hoc analysis using bootstrapping confidence intervals

No more AUC or time bins analysis! Ever

Follow our simple step by step instructions.

@foldi.bsky.social @philjrdb.bsky.social

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Marie K Holt

Gerome Breen @psychgenomics.bsky.social · Jun 17

Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n

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Reposted by Marie K Holt

Abby Polter @ampolter.bsky.social · Jun 12

New work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!

Sex‐Specific Adaptations to VTA Circuits Following Subchronic Stress

Subchronic variable stress, a paradigm shown to have divergent behavioral effects in males and females, induces shared and distinct physiological adaptations in the VTA. While both males and females ...

onlinelibrary.wiley.com

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Marie K Holt @mkbholt.bsky.social · Jun 16

Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩‍🔬👨‍🔬

My department is hiring! Closing on June 30th.

Please repost widely!

www.jobs.ac.uk/job/DNK944/a...

Assistant or Associate Professor in Mammalian Neuroscience (110565-0625) at University of Warwick

Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

www.jobs.ac.uk

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Reposted by Marie K Holt

Maurice Elphick @mauriceelphick.bsky.social · May 23

Here in the School of Biological & Behavioural Sciences at QMUL we are seeking to appoint a Teaching Fellow in #Bioinformatics. Please spread the word and encourage applications from suitable candidates. Deadline for applications is June 4th.
qmul-jobs.tal.net/vx/appcentre...

Teaching Fellow in Bioinformatics - QMUL Jobs

ID: 6278. Title: Teaching Fellow in Bioinformatics. Application Deadline:

qmul-jobs.tal.net

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Reposted by Marie K Holt

Mathias V. Schmidt @mathiasvschmidt.bsky.social · May 23

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

The evolving neurobiology of early-life stress

This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...

www.cell.com

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Reposted by Marie K Holt

Michael Baym @baym.lol · May 13

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

A screenshot of the termination notice showing "Outstanding Investigator Grants"

A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted

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Reposted by Marie K Holt

Thiago Carvalho @cyrilpedia.bsky.social · May 12

“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”

Is the UK paying the price for world’s most expensive visas? | The Observer

Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK

observer.co.uk

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Reposted by Marie K Holt

Sam Woodburn @samcwoodburn.bsky.social · May 13

Microglia are often framed as driving maladaptive behavior in stress and depression, but what if they're important for treatment as well?

In the final project from my graduate studies, we explored whether microglial BDNF supports the effects of low-dose ketamine.

www.biorxiv.org/content/10.1...

Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine

Microglia have been implicated in the pathogenesis for several psychiatric disorders, yet comparatively little is known about their role in treatments for these conditions. Prior work showed that the ...

www.biorxiv.org

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Reposted by Marie K Holt

Kate Jeffery @katejj.bsky.social · May 8

Brain/behaviour people - come to beautiful Scotland - we are recruiting in psychology and neuroscience across all grades! Closes May 12. Details below, and please re-post 🙏

www.nature.com/naturecareer...

More about us here: www.gla.ac.uk/schools/psyc...

#neuroskyence #neurojobs

Professor, Senior Lecturer/Lecturer and Lecturer posts - Glasgow City (GB) job with University of Glasgow | 12838283

University of Glasgow College of Medical, Veterinary and Life Sciences School of Psychology & Neuroscience Professor in Cognitive Neuroscience/Psy...

www.nature.com

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Reposted by Marie K Holt

Tune H Pers @tunepers.bsky.social · May 2

These are not good news for us foreigners who are (or plan to be) co-PI an NIH grants @altnih4science.bsky.social. Anybody who knows whether they plan to terminate ongoing R01 grants?

www.nature.com/articles/d41...

Exclusive: NIH to end billions of dollars in foreign research grants

Move by US biomedical agency jeopardizes thousands of projects on infectious diseases, cancer and more.

www.nature.com

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Marie K Holt @mkbholt.bsky.social · May 2

www.nature.com/articles/s42...

GIP is such a strange hormone. I'm glad these two companion papers can shed some light on the mystery...

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism

This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

www.nature.com

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Marie K Holt @mkbholt.bsky.social · May 2

www.nature.com/articles/s42...

Anyone else find GIP super confusing - but in an exciting way?

GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice - Nature Metabolism

This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, exp...

www.nature.com

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