mmgomezheras.bsky.social
Manuel M. Gómez de las Heras
@mmgomezheras.bsky.social
43 followers 140 following 3 posts
Postdoc researcher 🧬🥼 | Tissue immunity & Aging | María Mittelbrunn's lab
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mmgomezheras.bsky.social
Manuel M. Gómez de las Heras @mmgomezheras.bsky.social · Aug 6
Fresh from the oven 🧨💥

We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity

🔥 👵🏻

www.science.org/doi/10.1126/...
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
www.science.org
2 2 7
Reposted by Manuel M. Gómez de las Heras
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 27d
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV @cellcellpress.bsky.social @ragoninstitute.bsky.social @harvardmed.bsky.social
www.cell.com/cell/fulltex...
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
PPARγ downregulation in colonic CD8+ T cells from people with HIV (PWH) on antiretroviral therapy (ART) disrupts lipid metabolism and promotes contact-dependent epithelial apoptosis, leading to intest...
www.cell.com
1 1 2
Reposted by Manuel M. Gómez de las Heras
nataging.nature.com
Nature Aging @nataging.nature.com · May 5
Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype.
doi.org/10.1038/s435...
KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging
Nature Aging - T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate...
rdcu.be
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mmgomezheras.bsky.social
Manuel M. Gómez de las Heras @mmgomezheras.bsky.social · Aug 11
Thank you, Gustavo! Finally out 😊
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Reposted by Manuel M. Gómez de las Heras
cbm-csic-uam.bsky.social
Centro de Biología Molecular Severo Ochoa @cbm-csic-uam.bsky.social · Aug 5
El grupo de María Mittelbrunn en el CBM descubre un mecanismo celular que altera la microbiota intestinal y aumenta la aparición de enfermedades. Con una terapia celular lograron restaurar la inmunidad intestinal y prevenir estos efectos.

www.cbm.uam.es/index.php/20...
Descubren un mecanismo celular que altera la microbiota intestinal y aumenta la aparición de enfermedades múltiples - Centro de Biología Molecular Severo Ochoa
La pérdida de función de los linfocitos T CD4 altera la microbiota intestinal y, en consecuencia, acelera el envejecimiento celular y aumenta el riesgo de enfermedades múltiples. Es lo que […]
www.cbm.uam.es
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Reposted by Manuel M. Gómez de las Heras
csic.es
CSIC @csic.es · Aug 4
🔬Un estudio del CSIC demuestra que el deterioro asociado a la edad de los linfocitos T CD4 debilita la barrera intestinal y favorece la inflamación crónica y el envejecimiento celular

💉 El trabajo también presenta una posible terapia

➡️ https://tinyurl.com/97ssrv74
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mmgomezheras.bsky.social
Manuel M. Gómez de las Heras @mmgomezheras.bsky.social · Aug 7
Thank you, Matt 😊
1
Reposted by Manuel M. Gómez de las Heras
lozanzi.bsky.social
Ivan Zanoni @lozanzi.bsky.social · Aug 2
#WeekendRead! #LiveForever & #MicrobiotaPower! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature #inflammaging by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer! doi.org/10.1126/scii...
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
doi.org
3 7
mmgomezheras.bsky.social
Manuel M. Gómez de las Heras @mmgomezheras.bsky.social · Aug 6
Fresh from the oven 🧨💥

We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity

🔥 👵🏻

www.science.org/doi/10.1126/...
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
www.science.org
2 2 7
Reposted by Manuel M. Gómez de las Heras
immunoeditor.bsky.social
Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1
This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
www.science.org
1 3 4
Reposted by Manuel M. Gómez de las Heras
immunoeditor.bsky.social
Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...
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Reposted by Manuel M. Gómez de las Heras
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Aug 1
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging @sciimmunology.bsky.social @mmgomezheras.bsky.social
www.science.org/doi/10.1126/...
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