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Moritz Gerstung @moritzgerstung.bsky.social · 2d

A spatial transcriptomics analysis led by my student Zaira reveals the distinct nature (gene expression, tumour cell states and local microenvironments) of radionecrosis and recurrence in glioblastoma. 👏

zaira seferbekova 👩🏻‍💻 @zaira-sef.bsky.social · 2d

🚨 new glioblastoma preprint alert!

we present the first spatially resolved single cell atlas comparing radionecrotic changes (RN) and recurrent IDH-wildtype glioblastoma (GB) –– shedding light on a long-standing diagnostic challenge.

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Reposted by Moritz Gerstung

Deutsches Krebsforschungszentrum (DKFZ) @dkfz.bsky.social · 20d

Scientists from @embl.org and DKFZ have developed an AI model that assesses the long-term individual risk for more than 1,000 diseases. The model can predict health events over a period of more than a decade. @moritzgerstung.bsky.social @nature.com
t1p.de/zmjfg

AI model predicts disease risks decades in advance

Scientists from the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Center (DKFZ) have developed an AI model that assesses the long-term individual risk for more than 1,000...

t1p.de

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Reposted by Moritz Gerstung

EMBL-EBI @ebi.embl.org · 21d

What if you could get a glimpse of the future of your health, today?

Our scientists have developed a new generative AI model, trained using large-scale health records, that can estimate how human health may change over time.

Watch to find out more.

🖥️🧬

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Moritz Gerstung @moritzgerstung.bsky.social · Jul 29

This is a great set of methods for studying combinatorial effects of cancer mutations on spatial phenotypes.

Clever experimental design by @breinigmarco.bsky.social hijacking Visium and elegant analysis by @lomakinai.bsky.social and @elihei.bsky.social

www.nature.com/articles/s41...

Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships - Nature Biomedical Engineering

A method integrates perturbation mapping with 10X Visium spatial transcriptomics to map tumour genetic complexity and heterogeneity.

www.nature.com

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Reposted by Moritz Gerstung

Omer Ali Bayraktar @bayraktarlab.bsky.social · May 16

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

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Reposted by Moritz Gerstung

Nature Reviews Genetics @natrevgenet.nature.com · Apr 29

Spatial biology of cancer evolution go.nature.com/44hbib6 #Review by Zaira Seferbekova, @lomakinai.bsky.social, Lucy R. Yates & @moritzgerstung.bsky.social
Free to read here: rdcu.be/c1jwe

Spatial biology of cancer evolution - Nature Reviews Genetics

In this Review, the authors discuss our latest understanding of the spatial aspects of cancer evolution, including the roles of cancer subclonal structure, tissue architecture, and interactions betwee...

go.nature.com

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 26

Our experience with the multimodal seg is similar as yours- works great for many cell types or tissues, but not all.

Plus there can be contaminating transcripts on top.

Moritz Gerstung @moritzgerstung.bsky.social · Mar 26

Thank you! Yes, we believe segger has an edge over membrane-based segmentation because it also recognises the co-occurrence of transcripts. You can also use 10x multi-modal instead of nuclear segmentation as seggers input.

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 20

and also myeloproliferative neoplasms.

Back then, the implementation was very clunky and could only be done by R experts.

ebmstate now makes the inference much easier with only a few lines of code.

www.nejm.org/doi/full/10....

Classification and Personalized Prognosis in Myeloproliferative Neoplasms | NEJM

Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of...

www.nejm.org

Moritz Gerstung @moritzgerstung.bsky.social · Mar 20

This type of model predicts a patient’s journey across several mid- and endpoints and relates the progression to hundreds of variables.

It was used to learn detailed prognostic models for acute myeloid leukaemia ..

www.nature.com/articles/ng....

Precision oncology for acute myeloid leukemia using a knowledge bank approach - Nature Genetics

Peter Campbell, Hartmut Döhner and colleagues present an analysis of genetic mutations and clinical information from 1,540 patients with acute myeloid leukemia, demonstrating the utility of clinical k...

www.nature.com

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 20

Some classical statistics today.

ebmstate, an R package for multistate models with empirical Bayes covariate effect estimation.

Developed by Rui Costa during his postdoc in my group.

doi.org/10.32614/RJ-...

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Reposted by Moritz Gerstung

danapeer.bsky.social @danapeer.bsky.social · Mar 20

From great collaborations come great things. Excited to share Segger, the solution to segmentation of spatial transcriptomics (ST) data, with the @steglelab.bsky.social and @moritzgerstung.bsky.social labs, spearheaded by the great Andrew Moorman and Elyas Heidari www.biorxiv.org/content/10.1...

Segger: Fast and accurate cell segmentation of imaging-based spatial transcriptomics data

The accurate assignment of transcripts to their cells of origin remains the Achilles heel of imaging-based spatial transcriptomics, despite being critical for nearly all downstream analyses. Current c...

www.biorxiv.org

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Reposted by Moritz Gerstung

Stegle Lab @steglelab.bsky.social · Mar 18

1/ New preprint! 🍳

@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!

doi.org/10.1101/2025...

Message passing intuition behind the segger’s link-prediction model and the network architecture

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 18

Also tagging Elyas Heidari @elihei.bsky.social here who led this fantastic work.

Moritz Gerstung @moritzgerstung.bsky.social · Mar 17

A great thanks goes to all the other authors and contributors from the Gerstung, Stegle and Peer labs who made this work possible.

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 17

Segger comes as robust open-source software and has already been tested by many in the community. github.com/EliHei2/segg...

GitHub - EliHei2/segger_dev: a cutting-edge cell segmentation model specifically designed for single-molecule resolved spatial omics datasets. It addresses the challenge of accurately segmenting indiv...

a cutting-edge cell segmentation model specifically designed for single-molecule resolved spatial omics datasets. It addresses the challenge of accurately segmenting individual cells in complex ima...

github.com

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 17

Andrew Moorman and other members of @danapeer.bsky.social's lab helped carry out a rigorous assessment based on various 10x Xenium data sets with bespoke segmentation stainings, providing the ground truth to demonstrate segger's superior performance.

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 17

Segger is a super fast graph neural network algorithm, which makes cell segmentation much more reliable and faster.

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Moritz Gerstung @moritzgerstung.bsky.social · Mar 17

Spatial transcriptomics holds great promise to understand biological tissue function, but the assignment of transcripts to cells has been a substantial bottleneck.

For this reason, Elyas Heidari, a student in my lab and in @steglelab.bsky.social built segger.

www.biorxiv.org/content/10.1...

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Reposted by Moritz Gerstung

Daniel MacArthur @dgmacarthur.bsky.social · Mar 15

New preprint! We worked with @msftresearch.bsky.social and @broadinstitute.org to see whether large language models (LLMs) can be useful to variant scientists in deciding whether genetic variants seen in a patient are responsible for their disease. tl;dr yes they can: www.biorxiv.org/content/10.1...

Evidence Aggregator: AI reasoning applied to rare disease diagnostics

Retrieving, reviewing, and synthesizing technical information can be time-consuming and challenging, particularly when requiring specialized expertise, as is the case of variant assessment for rare di...

www.biorxiv.org

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Reposted by Moritz Gerstung

George Davey Smith @mendelrandom.bsky.social · Jan 23

Looking forward to @moritzgerstung.bsky.social seminar @uob-ieu.bsky.social on 30th Jan 2025 at 1pm, ,“ Using AI to Predict Disease Risks” in person and on line bristol-ac-uk.zoom.us/j/94273829130

Join our Cloud HD Video Meeting

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...

bristol-ac-uk.zoom.us

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Moritz Gerstung @moritzgerstung.bsky.social · Nov 20

Amazing work. We‘re all walking laboratories for somatic evolution.

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Reposted by Moritz Gerstung

Inigo Martincorena @imartincorena.bsky.social · Nov 20

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Somatic mutation and selection at epidemiological scale

As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

www.medrxiv.org

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Moritz Gerstung @moritzgerstung.bsky.social · Nov 20

Safe travels! We’re still waiting for the snow you got yesterday to arrive but chances look slim. Probably better travel wise.

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Moritz Gerstung @moritzgerstung.bsky.social · Nov 18

Thanks. Was on a bit of a social media hiatus, but this place looks like a new hope.

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