Andrea Movilli
@movillome.bsky.social
Doctoral researcher, going genome-wide at Weigelworld, @MPI for Biology Tübingen. TE & ME
Reposted by Andrea Movilli
🧪🌱 Sooo… our paper on how SPOROCYTELESS/NOZZLE controls the onset of megasporogenesis is finally out in @natcomms.nature.com 🎉🎉! This is one of the major projects of my postdoc at #LuciaColombo’s lab at #UniMI. www.nature.com/articles/s41... 🧶 1/7
SPOROCYTELESS/NOZZLE cooperates with MADS-domain transcription factors to regulate an auxin-dependent network controlling Megaspore-Mother-Cell differentiation - Nature Communications
In plants, the MMC represents the precursor of the female germline. Here, the authors show that SPL/NZZ, together with ovule-identity MADS-domain transcription factors, controls MMC differentiation by...
www.nature.com
December 15, 2025 at 9:56 PM
🧪🌱 Sooo… our paper on how SPOROCYTELESS/NOZZLE controls the onset of megasporogenesis is finally out in @natcomms.nature.com 🎉🎉! This is one of the major projects of my postdoc at #LuciaColombo’s lab at #UniMI. www.nature.com/articles/s41... 🧶 1/7
Reposted by Andrea Movilli
✨Call open for a fully-funded PhD position✨
Looking for an enthusiastic student to join my upcoming Ambizione research group (🌱 Epigenome Diversity Lab 🌱, www.epidiversitylab.org) at ETH Zürich, starting August 2026! Apply here ↘️
jobs.ethz.ch/job/view/JOP...
Application deadline: January 31st, 2026
Looking for an enthusiastic student to join my upcoming Ambizione research group (🌱 Epigenome Diversity Lab 🌱, www.epidiversitylab.org) at ETH Zürich, starting August 2026! Apply here ↘️
jobs.ethz.ch/job/view/JOP...
Application deadline: January 31st, 2026
PhD position to study epigenomic diversity and altitude adaptation in Arabis alpina
jobs.ethz.ch
December 15, 2025 at 5:35 PM
✨Call open for a fully-funded PhD position✨
Looking for an enthusiastic student to join my upcoming Ambizione research group (🌱 Epigenome Diversity Lab 🌱, www.epidiversitylab.org) at ETH Zürich, starting August 2026! Apply here ↘️
jobs.ethz.ch/job/view/JOP...
Application deadline: January 31st, 2026
Looking for an enthusiastic student to join my upcoming Ambizione research group (🌱 Epigenome Diversity Lab 🌱, www.epidiversitylab.org) at ETH Zürich, starting August 2026! Apply here ↘️
jobs.ethz.ch/job/view/JOP...
Application deadline: January 31st, 2026
Reposted by Andrea Movilli
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen - Nature Communications
In this study, the authors analysed a large genomic dataset to trace how jumping genes shaped the global spread of a major wheat pathogen and reveal bursts of activity over decades that drove adaptati...
www.nature.com
November 12, 2025 at 1:17 PM
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Reposted by Andrea Movilli
Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below!
doi.org/10.1126/scie...
doi.org/10.1126/scie...
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
doi.org
September 18, 2025 at 6:35 PM
Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below!
doi.org/10.1126/scie...
doi.org/10.1126/scie...
Reposted by Andrea Movilli
How diverse are the individual strains within your species?
How broad is their Pangenome?
How will you choose representatives from the whole collection?
Look no further! PanGene-O-Meter is here for you!
From @haimashkenazy.bsky.social @plantevolution.bsky.social
www.biorxiv.org/content/10.1...
How broad is their Pangenome?
How will you choose representatives from the whole collection?
Look no further! PanGene-O-Meter is here for you!
From @haimashkenazy.bsky.social @plantevolution.bsky.social
www.biorxiv.org/content/10.1...
PanGene-O-Meter: Intra-Species Diversity Based on Gene-Content
Bacterial genome evolution is shaped to a great extent by horizontal gene transfer, detectable as genes with a presence-absence pattern of variation that does not follow phylogenetic relationships acr...
www.biorxiv.org
September 2, 2025 at 7:20 AM
How diverse are the individual strains within your species?
How broad is their Pangenome?
How will you choose representatives from the whole collection?
Look no further! PanGene-O-Meter is here for you!
From @haimashkenazy.bsky.social @plantevolution.bsky.social
www.biorxiv.org/content/10.1...
How broad is their Pangenome?
How will you choose representatives from the whole collection?
Look no further! PanGene-O-Meter is here for you!
From @haimashkenazy.bsky.social @plantevolution.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Andrea Movilli
#TEsky A Concise Guide for the Characterization and Curation of Transposable Elements in Insect Genomes from valentinapeona.bsky.social doi.org/10.1007/978-...
A Concise Guide for the Characterization and Curation of Transposable Elements in Insect Genomes
Transposable elements (TEs) can play a huge role in shaping the structure and evolution of genes and genomes, but it can be difficult, especially in non-model organisms, to confidently characterize th...
doi.org
August 25, 2025 at 12:52 PM
#TEsky A Concise Guide for the Characterization and Curation of Transposable Elements in Insect Genomes from valentinapeona.bsky.social doi.org/10.1007/978-...
Reposted by Andrea Movilli
Happy to be able to finally share our NLR pangenome paper, out now in CHM.
"Pangenomic context reveals the extent of intraspecific plant NLR evolution"
www.cell.com/cell-host-mi...
#plantscience #plantimmunity #pangenomes #science #nlr
"Pangenomic context reveals the extent of intraspecific plant NLR evolution"
www.cell.com/cell-host-mi...
#plantscience #plantimmunity #pangenomes #science #nlr
Pangenomic context reveals the extent of intraspecific plant NLR evolution
Individual- and population-level diversity is required for pathogen defense by nucleotide-binding
site leucine-rich repeat (NLR) proteins. Teasdale et al. leverage annotated, divergent
A. thaliana gen...
www.cell.com
August 14, 2025 at 5:55 AM
Happy to be able to finally share our NLR pangenome paper, out now in CHM.
"Pangenomic context reveals the extent of intraspecific plant NLR evolution"
www.cell.com/cell-host-mi...
#plantscience #plantimmunity #pangenomes #science #nlr
"Pangenomic context reveals the extent of intraspecific plant NLR evolution"
www.cell.com/cell-host-mi...
#plantscience #plantimmunity #pangenomes #science #nlr
Reposted by Andrea Movilli
Super excited to share our new preprint! 🎉 This project has been an incredible learning experience, thanks to the amazing lab and wonderful people I get to work with. Huge thanks to my supervisor! @plantevolution.bsky.social
1/3 New preprint led by Shanshan Wang, in collaboration with the Timmermans lab.
Several groups have presented sc/snRNA-seq analyses of Arabidopsis leaves after bacterial infection before. Is there anything left to discover? Turns out: Yes.
#plantscience
www.biorxiv.org/content/10.1...
Several groups have presented sc/snRNA-seq analyses of Arabidopsis leaves after bacterial infection before. Is there anything left to discover? Turns out: Yes.
#plantscience
www.biorxiv.org/content/10.1...
August 4, 2025 at 7:41 AM
Super excited to share our new preprint! 🎉 This project has been an incredible learning experience, thanks to the amazing lab and wonderful people I get to work with. Huge thanks to my supervisor! @plantevolution.bsky.social
Reposted by Andrea Movilli
Paper led by @movillome.bsky.social on unbiased detection of (somatic) #TE insertions in #Arabidopsis with @pacbio.bsky.social long reads out after peer review. Thanks to academic editor Leandro Quadrana for shepherding it through the review process.
#plantscience
link.springer.com/article/10.1...?
#plantscience
link.springer.com/article/10.1...?
Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals - Genome Biology
Background Because transposable elements (TEs) can cause heritable genetic changes, past work on TE mobility in Arabidopsis thaliana has mostly focused on new TE insertions in the germline of hypometh...
link.springer.com
July 31, 2025 at 7:43 AM
Paper led by @movillome.bsky.social on unbiased detection of (somatic) #TE insertions in #Arabidopsis with @pacbio.bsky.social long reads out after peer review. Thanks to academic editor Leandro Quadrana for shepherding it through the review process.
#plantscience
link.springer.com/article/10.1...?
#plantscience
link.springer.com/article/10.1...?
Reposted by Andrea Movilli
1/2 Somatic TE transposition in plants is getting traction again (70 years after McClintock's discovery of "controlling elements")! A very large collection of somatic TE insertions in A. thaliana described by Ambreen et al.(www.biorxiv.org/content/10.1...).
July 21, 2025 at 2:20 PM
1/2 Somatic TE transposition in plants is getting traction again (70 years after McClintock's discovery of "controlling elements")! A very large collection of somatic TE insertions in A. thaliana described by Ambreen et al.(www.biorxiv.org/content/10.1...).
Reposted by Andrea Movilli
It's finally out!🎉
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
www.nature.com
July 16, 2025 at 3:04 PM
It's finally out!🎉
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
Reposted by Andrea Movilli
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted by Andrea Movilli
In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis.
Learn more here:
➡️ tinyurl.com/gd352270
Learn more here:
➡️ tinyurl.com/gd352270
April 22, 2025 at 8:00 PM
In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis.
Learn more here:
➡️ tinyurl.com/gd352270
Learn more here:
➡️ tinyurl.com/gd352270
Reposted by Andrea Movilli
New study with @petrollromy.bsky.social @borglab.bsky.social traces the evolution of epigenetic silencing in plants. Deep conservation of PRC2-mediated H3K27me3 marks across green algae suggest ancient, conserved networks of gene repression.
🔗 doi.org/10.1093/molb...
#evobio #molevol #plants
🔗 doi.org/10.1093/molb...
#evobio #molevol #plants
The Expansion and Diversification of Epigenetic Regulatory Networks Underpins Major Transitions in the Evolution of Land Plants
Abstract. Epigenetic silencing is essential for regulating gene expression and cellular diversity in eukaryotes. While DNA and H3K9 methylation silence tra
doi.org
April 17, 2025 at 5:32 PM
New study with @petrollromy.bsky.social @borglab.bsky.social traces the evolution of epigenetic silencing in plants. Deep conservation of PRC2-mediated H3K27me3 marks across green algae suggest ancient, conserved networks of gene repression.
🔗 doi.org/10.1093/molb...
#evobio #molevol #plants
🔗 doi.org/10.1093/molb...
#evobio #molevol #plants
Reposted by Andrea Movilli
The Custom-Lab Institute was featured in Germany's most important journal on the latest news from the life sciences sector, the "Laborjournal"! 😍
April 16, 2025 at 10:03 AM
The Custom-Lab Institute was featured in Germany's most important journal on the latest news from the life sciences sector, the "Laborjournal"! 😍
Reposted by Andrea Movilli
When you go to wrong hotel, but right plant
March 25, 2025 at 6:02 PM
When you go to wrong hotel, but right plant
Reposted by Andrea Movilli
Deadline was just extended to 30th March! :)
Please spread the word🙏:
[PhD Position in Computational Evolutionary Transcriptomics]
If you are interested in doing a PhD in gorgeous Scotland on 'Why embryo development goes wrong sometimes?', please consider applying and join our wonderful team in Dundee!
www.dundee.ac.uk/phds/opportu...
[PhD Position in Computational Evolutionary Transcriptomics]
If you are interested in doing a PhD in gorgeous Scotland on 'Why embryo development goes wrong sometimes?', please consider applying and join our wonderful team in Dundee!
www.dundee.ac.uk/phds/opportu...
How do ancient genes regulate animal embryo development at single cell resolution | University of Dundee, UK
A PhD project at the University of Dundee
www.dundee.ac.uk
March 23, 2025 at 5:23 PM
Deadline was just extended to 30th March! :)
Reposted by Andrea Movilli
🧪 I know it sounds like a cliché but I am TRULY AND UTTERLY THRILLED that this work from my postdoc at #unimi is out. SPL/NZZ is a very important gene (it initiates sporogenesis) but a very mysterious one. 🧵
1/8
1/8
SPOROCYTELESS/NOZZLE acts together with MADS-domain transcription factors to regulate an auxin-dependent network controlling the Megaspore Mother Cell development https://www.biorxiv.org/content/10.1101/2025.03.11.641985v1
March 14, 2025 at 8:05 AM
🧪 I know it sounds like a cliché but I am TRULY AND UTTERLY THRILLED that this work from my postdoc at #unimi is out. SPL/NZZ is a very important gene (it initiates sporogenesis) but a very mysterious one. 🧵
1/8
1/8
Reposted by Andrea Movilli
Another @biorxiv-evobio.bsky.social preprint of work led by @wenfeixian.bsky.social. With our Lausanne colleagues, we revisit the Napoleon Oak. An earlier long-read genome had revealed a relatively low number of somatic mutations (www.nature.com/articles/s41...).
1/2
1/2
Low number of fixed somatic mutations in a long-lived oak tree - Nature Plants
Sequencing of nested branches from a 234-year-old oak tree reveals a low number of somatic mutations accumulating during its lifetime, implying that mechanisms are in place to reduce these potentially...
www.nature.com
February 16, 2025 at 2:48 PM
Another @biorxiv-evobio.bsky.social preprint of work led by @wenfeixian.bsky.social. With our Lausanne colleagues, we revisit the Napoleon Oak. An earlier long-read genome had revealed a relatively low number of somatic mutations (www.nature.com/articles/s41...).
1/2
1/2
Reposted by Andrea Movilli
I am very excited to see my first PhD paper out as a preprint. "The expanded Bostrychia moritziana genome unveils evolution in the most diverse and complex order of red algae". Huge thanks to @borglab.bsky.social for the great supervision and guidance through this exciting project!🎉
🚨Preprint Alert🚨 I'm really happy to finally share our exploits in red algae and introduce the wider community to Bostrychia, the new model system we have been developing to tackle the molecular biology of red algae. Isn't she a beauty? Thread below 🧵 1/8 www.biorxiv.org/content/10.1...
February 12, 2025 at 10:09 AM
I am very excited to see my first PhD paper out as a preprint. "The expanded Bostrychia moritziana genome unveils evolution in the most diverse and complex order of red algae". Huge thanks to @borglab.bsky.social for the great supervision and guidance through this exciting project!🎉
Reposted by Andrea Movilli
🚨Preprint Alert🚨 I'm really happy to finally share our exploits in red algae and introduce the wider community to Bostrychia, the new model system we have been developing to tackle the molecular biology of red algae. Isn't she a beauty? Thread below 🧵 1/8 www.biorxiv.org/content/10.1...
February 12, 2025 at 8:37 AM
🚨Preprint Alert🚨 I'm really happy to finally share our exploits in red algae and introduce the wider community to Bostrychia, the new model system we have been developing to tackle the molecular biology of red algae. Isn't she a beauty? Thread below 🧵 1/8 www.biorxiv.org/content/10.1...
Reposted by Andrea Movilli
@movillome.bsky.social first-author preprint at @biorxiv-genomic.bsky.social from his PhD work at @maxplanckcampus.bsky.social, tackles the detection of TE mobilization. It’s inspiring to follow his progress and see his contributions to the field. 👏🏼👏🏼👏🏼Looking forward to seeing more! #Plantsci
In our latest @biorxiv-genomic.bsky.social preprint, we describe our approach to use PacBio HiFi reads to detect somatic TE transposition -- good enough to detect rare events that are present in only single cells. Led by Andrea Movilli.
#plantscience
www.biorxiv.org/content/10.1...
#plantscience
www.biorxiv.org/content/10.1...
February 11, 2025 at 9:29 AM
@movillome.bsky.social first-author preprint at @biorxiv-genomic.bsky.social from his PhD work at @maxplanckcampus.bsky.social, tackles the detection of TE mobilization. It’s inspiring to follow his progress and see his contributions to the field. 👏🏼👏🏼👏🏼Looking forward to seeing more! #Plantsci
Reposted by Andrea Movilli
In our latest @biorxiv-genomic.bsky.social preprint, we describe our approach to use PacBio HiFi reads to detect somatic TE transposition -- good enough to detect rare events that are present in only single cells. Led by Andrea Movilli.
#plantscience
www.biorxiv.org/content/10.1...
#plantscience
www.biorxiv.org/content/10.1...
February 10, 2025 at 10:57 AM
In our latest @biorxiv-genomic.bsky.social preprint, we describe our approach to use PacBio HiFi reads to detect somatic TE transposition -- good enough to detect rare events that are present in only single cells. Led by Andrea Movilli.
#plantscience
www.biorxiv.org/content/10.1...
#plantscience
www.biorxiv.org/content/10.1...
Reposted by Andrea Movilli
🌱⤴️🧬⤵️ Really interesting preprint on somatic TE activity detected in methylation-deficient Arabidopsis lines! From @movillome.bsky.social et al.
A notable point is the variable extent of mobilization across individuals. Is it random or an environmental factor?
www.biorxiv.org/content/10.1...
A notable point is the variable extent of mobilization across individuals. Is it random or an environmental factor?
www.biorxiv.org/content/10.1...
February 10, 2025 at 11:35 AM
🌱⤴️🧬⤵️ Really interesting preprint on somatic TE activity detected in methylation-deficient Arabidopsis lines! From @movillome.bsky.social et al.
A notable point is the variable extent of mobilization across individuals. Is it random or an environmental factor?
www.biorxiv.org/content/10.1...
A notable point is the variable extent of mobilization across individuals. Is it random or an environmental factor?
www.biorxiv.org/content/10.1...
Reposted by Andrea Movilli
...and, of course, "activists" destroyed the trial field of the first CRISPR-edited crops grown in Italy.
mycrispr.blog/2024/06/21/s...
It's always the same with these people, and exactly what orgs like #GreenPeace promote. 🤮
#PlantScience #PlantGMOs #PlantNGTs
mycrispr.blog/2024/06/21/s...
It's always the same with these people, and exactly what orgs like #GreenPeace promote. 🤮
#PlantScience #PlantGMOs #PlantNGTs
June 21, 2024 at 2:15 PM
...and, of course, "activists" destroyed the trial field of the first CRISPR-edited crops grown in Italy.
mycrispr.blog/2024/06/21/s...
It's always the same with these people, and exactly what orgs like #GreenPeace promote. 🤮
#PlantScience #PlantGMOs #PlantNGTs
mycrispr.blog/2024/06/21/s...
It's always the same with these people, and exactly what orgs like #GreenPeace promote. 🤮
#PlantScience #PlantGMOs #PlantNGTs