Emile Gluck-Thaler
@mycomile.bsky.social
1.3K followers
440 following
12 posts
Understanding fungal interactions using genes, genomes and Starships 🧬🍄🚀Evolutionary Biologist and Asst Prof @UWMadison's Dept. of Plant Pathology | he/him |
plantpath.wisc.edu/faculty/emile-gluck-thaler/
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Emile Gluck-Thaler
@mycomile.bsky.social
· May 13
Giant transposons promote strain heterogeneity in a major fungal pathogen | mBio
No “one size fits all” option exists for treating fungal infections in large part
due to genetic and phenotypic variability among strains. Accounting for strain heterogeneity
is thus fundamental for d...
doi.org
Reposted by Emile Gluck-Thaler
Emile Gluck-Thaler
@mycomile.bsky.social
· May 26
Reposted by Emile Gluck-Thaler
Emile Gluck-Thaler
@mycomile.bsky.social
· May 13
Giant transposons promote strain heterogeneity in a major fungal pathogen | mBio
No “one size fits all” option exists for treating fungal infections in large part
due to genetic and phenotypic variability among strains. Accounting for strain heterogeneity
is thus fundamental for d...
doi.org
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Max Kozlov
@maxkozlov.bsky.social
· Mar 7
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Hank Green
@hankgreen.bsky.social
· Mar 2
Reposted by Emile Gluck-Thaler
Palmer Report
@palmerreport.com
· Feb 19
Reposted by Emile Gluck-Thaler
Shawna Reed
@profpathogen.bsky.social
· Feb 2
Reposted by Emile Gluck-Thaler
Reposted by Emile Gluck-Thaler
Emile Gluck-Thaler
@mycomile.bsky.social
· Jan 11
Team Thomma
@teamthomma.bsky.social
· Jan 10
Starship giant transposons dominate plastic genomic regions in a fungal plant pathogen and drive virulence evolution
Starships form a recently discovered superfamily of giant transposons in Pezizomycotina fungi, implicated in mediating horizontal transfer of diverse cargo genes between fungal genomes. Their elusive nature has long obscured their significance, and their impact on genome evolution remains poorly understood. Here, we reveal a surprising abundance and diversity of Starships in the phytopathogenic fungus Verticillium dahliae. Remarkably, Starships dominate the plastic genomic compartments involved in host colonization, are enriched in virulence-associated genes, and exhibit genetic and epigenetic characteristics associated with adaptive genome evolution. We further uncover extensive horizontal transfer of Starships between Verticillium species and, strikingly, from distantly related Fusarium fungi. Finally, we demonstrate how Starship activity facilitated the de novo formation of a novel virulence gene. Our findings illuminate the profound influence of Starship dynamics on fungal genome evolution and the development of virulence. ### Competing Interest Statement The authors have declared no competing interest.
doi.org
Reposted by Emile Gluck-Thaler