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Nadine Hillock @nadinehillock.bsky.social · 19d

Hardly any National Action Plans to address antimicrobial resistance include reducing antibiotic use as an explicit goal 🤯

Report shows only 3 countries had a significant reduction in sales after implementing their NAPs: Jordan, Sth Africa & Indonesia 👏👏
#AMR #NAP
doi.org/10.1017/ice....

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Nadine Hillock @nadinehillock.bsky.social · Jul 14

‘Pharma companies make money on a new drug by selling a lot or charging a lot - but with antimicrobials neither is possible.’ - Andrew Bowskill #AAMRNet.
Delinking funding from use is the only way to stimulate investment in new antimicrobials #MTPConnect #AMR #antimicrobials @drewabow.bsky.social

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Nadine Hillock @nadinehillock.bsky.social · Jul 14

Surveillance of antimicrobial use and resistance ‘in isolation is like counting raindrops in a thunderstorm’ - we need more investment in innovation and prevention of AMR. Dr Richard Alm
Speaking in Adelaide #MTPConnect #AAMRNet #AMR #PublicHealth #antimicrobials @carb-x.bsky.social

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Nadine Hillock @nadinehillock.bsky.social · Jun 9

Study highlights higher risk of multidrug-resistant pathogens in cancer patients: analysis of US data compared cancer outpatient cohort with non-cancer patients.
eg. 2-3x higher incidence of carbopenem-resistant P.aeruginosa #AMR #AMS
www.thelancet.com/journals/lan...
‪@thelancetoncol.bsky.social‬

Incidence and prevalence of antimicrobial resistance in outpatients with cancer: a multicentre, retrospective, cohort study

AMR proportions and IRRs for most key pathogens were up to three-times higher in isolates from outpatients with cancer than those without cancer, highlighting the need for enhanced surveillance, infec...

www.thelancet.com

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Nadine Hillock @nadinehillock.bsky.social · May 30

Tebipenem - a new oral carbapenem for complicated UTIs - efficacy data is good 😀

Marketing now the challenge - how to make it profitable for pharma but prevent overuse? 🤔

De-linked funding model needed!

#tebipenem #PIVOT-PO #antibiotic #de-linked #AMR #AMS

www.globenewswire.com/news-release...

Spero Therapeutics and GSK Announce PIVOT-PO Phase 3 Study for Tebipenem HBr Stopped Early for Efficacy Following Review by Independent Data Monitoring Committee

If approved, tebipenem HBr could be the first oral carbapenem antibiotic for US patients with complicated urinary tract infections (cUTIs) An estimated 2.9...

www.globenewswire.com

Reposted by Nadine Hillock

ASHE Journal @ashejournal.bsky.social · Apr 24

Topical use of last-line antibiotics during surgery largely undocumented - potential focus for stewardship and improved governance. Australian surveillance data illustrates rifampicin use not uncommon.
doi.org/10.1017/ash....

Off-label use of intravenous rifampicin during surgery: analysis of Australian surveillance data and retrospective audit at a tertiary hospital | Antimicrobial Stewardship & Healthcare Epidemiolog...

Off-label use of intravenous rifampicin during surgery: analysis of Australian surveillance data and retrospective audit at a tertiary hospital - Volume 5 Issue 1

doi.org

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Reposted by Nadine Hillock

Minyon Avent @minyonavent.bsky.social · May 21

To celebrate #IDPharmacistsDay look out for the videos from AdPha.au pharmacists showcasing their contributions to Innovations in Infectious Diseases @adphaau.bsky.social @nadinehillock.bsky.social @sonkoning.bsky.social @leggwamy.bsky.social @sidpharm.bsky.social

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Reposted by Nadine Hillock

Antimicrobial resistance #AMR @antimicrobial.bsky.social · May 18

Analysis of over 208K Salmonella genomes find that #AMR varies by region, source, and serovar, with increases linked to poultry and environment. Antibiotic use, agriculture, and climate drive AMR, offering insights into global spread and evolution.
#OneHealth

www.nature.com/articles/s41...

A global atlas and drivers of antimicrobial resistance in Salmonella during 1900-2023 - Nature Communications

Salmonella is a major cause of foodborne disease worldwide. Authors created a Salmonella database and present a genetic atlas of antimicrobial resistance, identifying some socioeconomic and environmen...

www.nature.com

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Reposted by Nadine Hillock

Antimicrobial resistance #AMR @antimicrobial.bsky.social · May 4

This large multi-center study shows cancer patients are infected with #AMR bacteria at 1.2 to 3 times higher rates due to frequent hospital visits and antibiotic use. This highlights the need for better antibiotic #stewardship and surveillance in these patients.

www.thelancet.com/journals/lan...

Incidence and prevalence of antimicrobial resistance in outpatients with cancer: a multicentre, retrospective, cohort study

AMR proportions and IRRs for most key pathogens were up to three-times higher in isolates from outpatients with cancer than those without cancer, highlighting the need for enhanced surveillance, infec...

www.thelancet.com

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Reposted by Nadine Hillock

Prof Sam Illingworth @samillingworth.com · May 12

🧪 Antibiotics in our rivers: a global problem

A new study has found that 8,500 tonnes of antibiotics from human use end up in rivers every year. In 6 million km of rivers, levels are high enough to harm ecosystems or promote resistance.

🔗 doi.org/10.1093/pnas...

#SciComm #WaterQuality #AMR

Antibiotics in the global river system arising from human consumption

Abstract. The presence of antibiotics in surface waters poses risks to aquatic ecosystems and human health due to their toxicity and influence on antimicro

doi.org

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Nadine Hillock @nadinehillock.bsky.social · May 9

Interesting webinar coming up on antimicrobial clinical trials conducted after marketing
#antimicrobial #AMR #ID
@steventong.bsky.social #PatrickHarris @gardp.bsky.social

register.gotowebinar.com/register/755...

register.gotowebinar.com

Nadine Hillock @nadinehillock.bsky.social · Apr 23

Sprinkles and washes ... the true extent of topical rifampicin use during surgery is unclear due to lack of documentation - a huge opportunity for stewardship and better governance
bit.ly/42nFmQT
Thanks to my co-authors Matt Rawlins and @edraby.bsky.social

#AMS #off-label #rifampicin #AMR #NAUSP

Off-label use of intravenous rifampicin during surgery: analysis of Australian surveillance data and retrospective audit at a tertiary hospital | Antimicrobial Stewardship & Healthcare Epidemiolog...

Off-label use of intravenous rifampicin during surgery: analysis of Australian surveillance data and retrospective audit at a tertiary hospital - Volume 5 Issue 1

bit.ly

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Nadine Hillock @nadinehillock.bsky.social · Apr 22

Price of pretomanid to drop by 25% to increase accessibility for patients with TB. Great example of how global public-private partnerships can increase access to antimicrobials while maintaining economic viability for manufacturing #TB #publichealth #antimicrobials

www.stoptb.org/news/global-...

Global Drug Facility Announces Another Big Price Drop: 25% Reduction in the Price of Pretomanid | Stop TB Partnership

www.stoptb.org

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Nadine Hillock @nadinehillock.bsky.social · Apr 22

Great comprehensive summary on the safe & effective use of vancomycin in the Australian Prescriber
australianprescriber.tg.org.au/articles/saf...
Congrats to the authors! @leggwamy.bsky.social @tonylai.bsky.social @feliciadevchand.bsky.social @amandagwee.bsky.social Indy Sandaradura
#vancomycin #AMS

Safe and effective use of vancomycin

Vancomycin is an important antimicrobial for the treatment of Gram-positive infections. To optimise efficacy and minimise toxicity, monitoring the area under the vancomycin concentration–time curve ov...

australianprescriber.tg.org.au

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Reposted by Nadine Hillock

CIDRAP @cidrap.bsky.social · Apr 18

Large study ties early-life antibiotic exposure to higher risk of asthma, allergies, other conditions

The authors of the observational study say the findings highlight the need for more judicious antibiotic prescribing in children under age 2.

www.cidrap.umn.edu/a...

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Reposted by Nadine Hillock

John Ross @johnrossmd.bsky.social · Apr 19

Staph aureus bacteremia take-homes from the SNAP trial:
1. Cefazolin = flucloxacillin (and presumably oxacillin and nafcillin)
2. Penicillin is just dandy for penicillin-susceptible Staph aureus, which is becoming (inexplicably) more common #IDSky

Paul Sax @paulsaxmd.bsky.social · Apr 18

The SNAP trial may finally resolve some of the longest-running debates in SAB management (cefazolin vs semi-synthetic PCN? Is PCN really active vs PSSA?).
Huge congrats to Drs. Joshua Davis, Steven Tong, & the global team who made this ambitious trial happen. #IDSky blogs.jwatch.org/hiv-id-obser...

SNAP Trial Helps Resolve Long-Running Controversies Over Management of Staph Bacteremia

For those who do hospital-based patient care, the significance of Staphylococcus aureus bacteremia (SAB) cannot be overstated. It’s one of the most frequent reasons for infectious disease consultation...

blogs.jwatch.org

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Nadine Hillock @nadinehillock.bsky.social · Apr 15

Deaths due to antimicrobial resistance are increasing, especially in children in South East Asia and Africa.

New study estimates 3 million kids died in 2022 globally due to AMR @cidrap.bsky.social #AMR #publichealth #mortality #antibioticresistance

www.cidrap.umn.edu/antimicrobia...

More than 3 million child deaths in 2022 linked to antimicrobial resistance

www.cidrap.umn.edu

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Reposted by Nadine Hillock

rakshakochi.bsky.social @rakshakochi.bsky.social · Apr 12

Go where the money is? No go where the AMR is.
Asia remains the epicenter of antimicrobial resistance, yet is underrepresented in clinical trials.
David Paterson’s keynote at #ESCMIDGlobal 2025 @escmid.bsky.social
underscores the urgency the need for urgent action 🙌
#AMR #ESCMIDGlobal2025

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Reposted by Nadine Hillock

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Apr 12

The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky

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Reposted by Nadine Hillock

Erin McCreary, PharmD @erinmccreary.bsky.social · Apr 12

@steventong.bsky.social presents the results of the PSSA domain of the SNAP 🫰 trial - the worlds largest trial of staph aureus bacteremia - at #ESCMID2025

fluclox resulted in higher mortality and more AKI compared to penicillin for PSSA

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Nadine Hillock @nadinehillock.bsky.social · Apr 13

JAMA review of Staph aureus bacteraemia.
Empiric treatment should include MRSA cover in areas with rates >5% or in patients with risk MRSA risk factors
#SAB @jama.com @steventong.bsky.social

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Nadine Hillock @nadinehillock.bsky.social · Apr 12

Guide to buying sustainable chocolate this Easter 🐰🐇
#GoodEgg versus #BadEgg
@theconversation.com

#antislavery #climatesmart #sustainability #genderequity

theconversation.com/heres-who-to...

Here’s who topped the rankings in this year’s scorecard for sustainable chocolate – and which confectionery giant refused to participate

The global Chocolate Scorecard evaluates traders and brands on efforts to address child labour, deforestation and other measures.

theconversation.com

Nadine Hillock @nadinehillock.bsky.social · Apr 7

Timely access to appropriate antimicrobials is essential for patient care, antimicrobial stewardship & minimising the risk of resistance - excellent summary of the issues here: amr.solutions/2025/04/07/y...

Thanks to @johnhrexmd.bsky.social for highlighting our paper

#AMR #AntibioticAccess #AMS 💊

You reach for the antibiotic ... and it's not there!

Dear All (with thanks to Louise for co-authoring and with a wonkish alert … settle in for the ride!), Today’s newsletter discusses the intersection of three themes around antibiotic access. Recall fir...

amr.solutions

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Reposted by Nadine Hillock

The Medical Journal of Australia @mja.com.au · Mar 20

🔔 NEW in the Medical Journal of Australia

Shortages of benzathine benzylpenicillin G in Australia highlight the need for new sovereign manufacturing capability

✍️ Rosemary Wyber, Glenn Pearson and Laurens Manning

OPEN ACCESS www.mja.com.au/journal/2025...

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Nadine Hillock @nadinehillock.bsky.social · Mar 19

Fantastic (& FREE) presentation from Assoc Prof Hayley Blackburn on reducing medication waste in hospitals. Pharmacy can lead on this! Medicines are key contributors to the healthcare carbon footprint & cause water pollution

adpha.au/event/medsaw...

#RxforClimate #OneHealth #AdPhA #AMR #medwaste

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