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Reposted by Nick Riley

Gautam Dey @gautamdey.bsky.social · 5d

If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back.

I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support

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Reposted by Nick Riley

Nick Riley @nmriley.bsky.social · 14d

Have you wondered how nanoparticle protein coronas (e.g., Seer’s Proteograph XT) can help with glycoprotein enrichment in biofluids?

We were curious, too, and this new @riley-research.bsky.social pre-print led by outstanding postdoc @emmajays.bsky.social details our #glycotime investigations.

Emmajay Sutherland @emmajays.bsky.social · 15d

Can nanoparticles help us probe the glycoproteome?

The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.

Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...

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Reposted by Nick Riley

Emmajay Sutherland @emmajays.bsky.social · 15d

Can nanoparticles help us probe the glycoproteome?

The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.

Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...

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Nick Riley @nmriley.bsky.social · 14d

We did not yet! Most of our glyco enrichments happen at the peptide level after trypsin digestion, so we were curious how the NP protein-level enrichment would pair with that. We are currently thinking about protein-level effects toward your point, but nothing to share at this point.

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Nick Riley @nmriley.bsky.social · 14d

NP enrichment also helped O-glycopeptide characterization, but MAX enrichment was less beneficial.

We looked into CSF, too. We think this is one of the first applications of Seer's NPs to CSF, so we did proteomics and glycoproteomics.

Be sure to check out the pre-print if this sounds interesting!

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Nick Riley @nmriley.bsky.social · 14d

It's rare that a single LC-MS/MS can provide IDs for all glycopeptides in a mixture, so we ran enrich enrichment multiple times on the instrument.

This allowed us to capture as much of the population of glycopeptides that we could -- an important thing when exploring how enrichment methods differ!

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Nick Riley @nmriley.bsky.social · 14d

Large dynamic range in biofluids is an issue for glycoproteomics just like with proteomics. We saw that Seer's NP mixtures (A and B) combined with MAX enrichment provided a boost in N-glycopeptide IDs relative to no nanoparticles (NP0), with the majority of IDs being unique to the NP enrichments.

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Nick Riley @nmriley.bsky.social · 14d

Have you wondered how nanoparticle protein coronas (e.g., Seer’s Proteograph XT) can help with glycoprotein enrichment in biofluids?

We were curious, too, and this new @riley-research.bsky.social pre-print led by outstanding postdoc @emmajays.bsky.social details our #glycotime investigations.

Emmajay Sutherland @emmajays.bsky.social · 15d

Can nanoparticles help us probe the glycoproteome?

The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.

Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...

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Reposted by Nick Riley

IonOpticks @ionopticks.bsky.social · 29d

Dr. Tim Veth, a postdoc working with @nmriley.bsky.social at the University of Washington, is tackling glycoproteomics. When we spoke about navigating the complexity of analysing thousands of glycoproteoforms, he shared how reliable chromatography supports his research.

Learn more: bit.ly/4nrMzad

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Reposted by Nick Riley

C&EN (Chemical & Engineering News) @cenmag.bsky.social · Aug 2

@nmriley.bsky.social, a chemical biologist at University of Washington and one of C&EN's Talented 12, will be speaking at the #CENT12 Symposium on Monday, August 18 in Washington, DC. RSVP here: connect.discoveracs.org/talented-12-...

Read more: cen.acs.org/biological-c...

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Reposted by Nick Riley

IonOpticks @ionopticks.bsky.social · Jul 23

"I invite all researchers to enter the glycoproteomics field and join the battle.”

With the complexity of glycoproteomics and how little we still know, Tim Veth puts out a rallying cry to speed up development in this promising field.

Learn more about Tim & read our discussion: bit.ly/3IXpo8B

Thousands of forms, one protein: how Tim Veth is deciphering the complex language of Glycans

Tim Veth, a postdoctoral researcher working with Prof. Nicholas M.

bit.ly

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Nick Riley @nmriley.bsky.social · Jul 23

@riley-research.bsky.social had a great time catching up with local research at the Cascadia Proteomics Symposium last week. The lineup featured talks from Katie Kothlow and Haley Schramm, and a lightning talk/poster from @emmajays.bsky.social

Congrats to Emmajay for her 2nd-place poster award too!

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Reposted by Nick Riley

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Jul 3

Can you believe there's more?! Check out a Spotlight from @timveth.bsky.social and @nmriley.bsky.social highlighting an article on glycoproteomics, and another from Lucia Alvarez and Lucia @chemeslab.bsky.social on intrinsically disordered proteins!

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Reposted by Nick Riley

Dan Garisto @dangaristo.bsky.social · Jun 25

The 500 additional GRFPs NSF awarded were not very evenly distributed across fields, it seems.
www.science.org/content/arti...

Plot showing skewed distribution toward comp science and applied physics

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Reposted by Nick Riley

Nick Riley @nmriley.bsky.social · Jun 24

We plan to highlight a new analytical chemist each quarter in the Division Newsletter. If you are interested in nominating someone to be highlighted, please enter their information here:

docs.google.com/forms/d/e/1F...

Meet an Analytical Chemist Suggestion Form

American Chemical Society Division of Analytical Chemistry Education Committee is sponsoring a new initiative called "Meet an Analytical Chemist" where we highlight a scientist from our community once...

docs.google.com

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Nick Riley @nmriley.bsky.social · Jun 24

We plan to highlight a new analytical chemist each quarter in the Division Newsletter. If you are interested in nominating someone to be highlighted, please enter their information here:

docs.google.com/forms/d/e/1F...

Meet an Analytical Chemist Suggestion Form

American Chemical Society Division of Analytical Chemistry Education Committee is sponsoring a new initiative called "Meet an Analytical Chemist" where we highlight a scientist from our community once...

docs.google.com

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Nick Riley @nmriley.bsky.social · Jun 24

She was also recognized recently as one of C&EN's Talented 12 (cen.acs.org/environment/...).

2025 Talented 12: Shira Joudan

Understanding sources of harmful contaminants

cen.acs.org

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Nick Riley @nmriley.bsky.social · Jun 24

The ACS Div. of Analytical Chem. Education Committee launched a "Meet an Analytical Chemist" initiative this spring to highlight members of our community.

Our newest entry showcases @shirajoudan.bsky.social, an Asst. Prof. of Chemistry at @ualberta.bsky.social. Check it out here: shorturl.at/7VFIR

Meet an Analytical Chemist – May 2025

Shira Joudan, Assistant ProfessorDepartment of Chemistry, University of Alberta How did you get started in the field of Analytical Chemistry? In undergrad, I took introductory analytical chemistry…

shorturl.at

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Reposted by Nick Riley

Mike Goodwin @massspecpro.bsky.social · Jun 12

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...

Alan Marshall: A scientist and a Gentleman - MagLab

Meet one of the greatest innovators in the history of mass spectrometry, hard at work.

nationalmaglab.org

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Reposted by Nick Riley

Iain Wilson @iainwilsonwien.bsky.social · Jun 5

Nick Riley @nmriley.bsky.social at #ASMS2025
Varying ETD and EThcD parameters (q and Tau values) for increase O-glycopeptide identifications.

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Reposted by Nick Riley

Nick Riley @nmriley.bsky.social · Jun 2

#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,

consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.

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Reposted by Nick Riley

Devin Schweppe @dschweppe.bsky.social · Jun 2

#ASMS2025
Come here about the latest in real-time instrument control including applications to single cell proteomics (@parallelsq.bsky.social), #glycotime, and quantitative proteomics!

Nick Riley @nmriley.bsky.social · Jun 2

#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,

consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.

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Nick Riley @nmriley.bsky.social · Jun 2

Organized by @dschweppe.bsky.social, Will Barshop, and me. See you there!

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Nick Riley @nmriley.bsky.social · Jun 2

#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,

consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.

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Nick Riley @nmriley.bsky.social · Jun 2

We look forward to talking with you and hearing about all the great science from our colleagues. Always exciting to be here and connect with folks!

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