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Sierra Palumbos @palumbos.bsky.social · Jul 7

Together, we describe two compensatory secretion pathways that could be important to delay neurodegeneration. However, prolonged upregulation of these pathways could contribute to neuroinflammation.

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Sierra Palumbos @palumbos.bsky.social · Jul 7

Additionally, we show the release of exosomes is upregulated and that this release is critical to stave off apoptosis

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Sierra Palumbos @palumbos.bsky.social · Jul 7

We find that the secretion of LC3+ autophagic membrane extracellular vesicles (SLAM-EVs) is upregulated in neurons harboring a Parkinson's disease causing mutation

SLAM-EVs contain known autophagic cargos including mitochondria and synaptic proteins

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Sierra Palumbos @palumbos.bsky.social · Jul 7

Very excited to share my postdoc work- out now at PNAS!

Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways

Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Reposted by Sierra Palumbos

Diana Fulmer @dianafulmer.bsky.social · Feb 18

This is going to hurt science. 🧪

What hurts science hurts healthcare. 🩺

What hurts healthcare hurts you. 🫵

Call, email, and if possible visit, your representatives. This is personal whether you want it to be or not.

Alexandra Witze @alexwitze.bsky.social · Feb 18

This morning, the US National Science Foundation fired 168 employees, approximately 10% of its workforce, for no cause other than they were the agency's most recent hires. 🧪

Co-workers are leaving supportive messages before they have to clear out of the building at 5 p.m. Sent to me by a source ⬇️

Handwritten notes on a metal table at the National Science Foundation, 2/18/25. The messages include "You deserve better! Thank you!"; "Thank you colleagues! This RIF is WRONG. These orders are immoral & illegal"; and "Your service will forever be remembered and deeply valued - ENG directorate".

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Reposted by Sierra Palumbos

Jeremy Berg @jeremymberg.bsky.social · Feb 11

Very good source to understand indirect costs by Sally Rockey, former Deputy Director for Extramural Activities at NIH.

Very thorough and clear.

If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this...

www.aau.edu/key-issues/i...

Indirect Costs 101, Sally J. Rockey | Association of American Universities (AAU)

Sally Rockey, explains indirect costs and how they support research.

www.aau.edu

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Reposted by Sierra Palumbos

Rick Huganir @rhuganir.bsky.social · Feb 7

This is the end of science as we know it if it stands—15% IDCs for all NIH Grants.

grants.nih.gov/grants/guide...

NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

grants.nih.gov

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Reposted by Sierra Palumbos

David F. Warner @dwarnersoc.bsky.social · Feb 7

⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.

—> Deep budget cuts & program closures coming to a university near you.

Is this the break the glass moment for university administrators who have been silent so far about the attack on science?

NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

grants.nih.gov

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Sierra Palumbos @palumbos.bsky.social · Feb 6

Revised and Extended: What's Happening Inside the NIH and NSF | Science | AAAS www.science.org/content/blog...

Revised and Extended: What's Happening Inside the NIH and NSF

www.science.org

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Reposted by Sierra Palumbos

mito911 @mito911.bsky.social · Jan 29

Shout out to Dr. Bishal Basak in @erikaholzbaur.bsky.social at @upenn.bsky.social for spearheading the work on identifying a new stress response pathway that regulates mitophagy in neurons!
➡️Read pre-print here: doi.org/10.1101/2024...

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Jan 29

🎉 We are celebrating Bishal Basak from CRN Team Hurley as our January #NetworkSpotlight. Bishal worked on a Team paper where he identified a novel, neuron-specific mitophagy pathway. Thank you, Bishal!

Check out Bishal's paper: www.biorxiv.org/content/10.1...

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Reposted by Sierra Palumbos

Meng-meng Fu @mengmengfu.bsky.social · Jan 24

If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.

I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!

Pls repost 🙏❤️

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Reposted by Sierra Palumbos

Zoe McElligott @nanopharmnc.bsky.social · Jan 22

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

NIH In Your State - United For Medical Research

Select a state on the map to see the impact of NIH funding across America.

www.unitedformedicalresearch.org

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Reposted by Sierra Palumbos

christine liu @christineliu.art · Jan 22

Step 1) find your rep

www.congress.gov/members/find...

Step 2) send an email or call their office

Step 3) tell them that federal spending on scientific advancement is the best hope we have to “win against china” or whatever these guys are obsessed with these days

www.congress.gov

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Reposted by Sierra Palumbos

Carl T. Bergstrom @carlbergstrom.com · Jan 22

Study sections are the review panels that allocate NIH research grants. They bring in experts from around the country and have to be scheduled many months in advance; they provide the funds that keep the nation's biomedical research going.

It's hard to overstate the disruption this causes.

Jane Liebschutz, MD MPH (she/her) @liebschutz.bsky.social · Jan 22

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

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Jane Liebschutz, MD MPH (she/her) @liebschutz.bsky.social · Jan 22

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

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Abby Polter @ampolter.bsky.social · Jan 23

The United States built a publicly funded scientific enterprise that worked miracles. We went to the moon and mars, laid the groundwork for computing revolutions, turned AIDS from a death sentence to a chronic condition, drastically cut cancer deaths. And now we're just going to dismantle it?

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Reposted by Sierra Palumbos

Aafke Gros @aafkegros.bsky.social · Jan 15

Microscopy Nodes is now up on bioRxiv! 🚀

This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev).

High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬

www.biorxiv.org/content/10.1...

FIB-SEM dataset visualized with Microscopy Nodes, data from Mocaer et al 2023

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Sierra Palumbos @palumbos.bsky.social · Nov 26

thank you, Xilma!

Reposted by Sierra Palumbos

mito911 @mito911.bsky.social · Nov 25

📣Now that @mito911.bsky.social is on Bluesky, let's highlight the research run in our team! Check out the pre-print by @palumbos.bsky.social Palumbos et al. and colleagues from the @erikaholzbaur.bsky.social!
@asapresearch.bsky.social
⬇️

Erika Holzbaur-Howland @erikaholzbaur.bsky.social · Nov 13

Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...

Autophagic stress activates distinct compensatory secretory pathways in neurons

Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...

www.biorxiv.org

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Reposted by Sierra Palumbos

mito911 @mito911.bsky.social · Nov 25

Read the recent pre-print by @palumbos.bsky.social now on BioRxiv. In the meanwhile, find below and read a thread for a sweet preview of her work! 👩‍🔬 🧫
@asapresearch.bsky.social

Sierra Palumbos @palumbos.bsky.social · Nov 15

Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons"

Now on BioRxiv www.biorxiv.org/content/10.1...

Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social

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Reposted by Sierra Palumbos

Namnezia 🥑 @namnezia.bsky.social · Nov 20

Do you teach neuroscience? Here’s a list I’ve compiled of mostly free online neuroscience textbooks, simulations and datasets you can use for your course! If I’m missing something, let me know so I can add it! docs.google.com/document/d/1...

Free Neuroscience Textbooks and Online Tutorials

Free Neuroscience Textbooks and Online Tutorials (Compiled by Carlos Aizenman, Brown University, Dept. of Neuroscience) Maintaining a current list of digital educational resources is tricky. Softwar...

docs.google.com

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Sierra Palumbos @palumbos.bsky.social · Nov 20

Would love to be added!

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Sierra Palumbos @palumbos.bsky.social · Nov 20

Been waiting for this one! Thank you!

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Reposted by Sierra Palumbos

Juan S. Bonifacino @juanbonifacino.bsky.social · Nov 17

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

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mito911 @mito911.bsky.social · Nov 15

If you are interested in mitochondria, mitophagy and/or PD follow the mito911 Webinar series! Events calendar and registration at this link parkinsonsroadmap.org/events/

Events

Aligning Science Across Parkinson’s (ASAP) aims to foster collaboration and discovery by supporting virtual and in-person events that facilitate connections and provide an avenue for sharing ideas. Se...

parkinsonsroadmap.org

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