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Reposted by Vincent Pasque

Marcus Buschbeck and Lab @marcusbuschbeck.bsky.social · 1d

Adios and salut to a pioneer!

Sir John Gurdon studied the requirements and barriers of #reprogramming.

Highly relevant for us, with his PhD student Vincent Pasque he showed that macroH2A is part of the epigenetic barrier inhibiting reprogramming.

Our thoughts are with his family and friends.

Manuel Collado @manuel-collado.bsky.social · 1d

Sad to hear about the passing of John Gurdon, a titan and pioneer of developmental biology and much more. Winner of the Nobel Prize in Medicine or Physiology, shared with Shinya Yamanaka, who actually was inspired by his work
www.cam.ac.uk/research/new...

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

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Vincent Pasque @pasquelab.bsky.social · 14h

Thank you, John, for lifting up everyone around you.

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Vincent Pasque @pasquelab.bsky.social · 14h

It is with profound sadness that I have learned of the passing of my beloved PhD supervisor, John Gurdon. We have lost a true giant, an incredible mentor, kind and generous, whose contributions to science will inspire generations. He changed my life, and the lives of so many others.

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Vincent Pasque @pasquelab.bsky.social · 6d

I spoke with Benjamin Thompson on the Nature Podcast about a new study that uses stem cell-based embryo models – blastoids – to uncover how a recently evolved cis-regulatory element became essential for early human embryo gene regulatory programs.

Tune in a share your thoughts below.

Nature Podcast @naturepodcast.bsky.social · 7d

This week on the pod:

🦠 How ancient viruses drive modern human development
🧬 How heat can fuel DNA computers
go.nature.com/42QSI7W

Ancient viral DNA helps human embryos develop

Hear the biggest stories from the world of science | 01 October 2025

go.nature.com

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Reposted by Vincent Pasque

Raquel Fueyo @fueyoraquel.bsky.social · 7d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

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Vincent Pasque @pasquelab.bsky.social · 7d

Congratulations to the Joanna Wysocka lab for their outstanding work that inspired this piece.
#blastoids #stemcells #KULeuven @kuleuvenuniversity.bsky.social

Vincent Pasque @pasquelab.bsky.social · 7d

Excited to share our latest News & Views published in Nature! @nature.com
rdcu.be/eI2NJ

Sherif Khodeer and I discuss how stem cell-based embryo models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.

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Vincent Pasque @pasquelab.bsky.social · 7d

Nieuw inzicht in hoe cellen genetisch evenwicht bewaren.

nieuws.kuleuven.be/nl/2025/nieu...

Nieuw inzicht in hoe cellen genetisch evenwicht bewaren

Onderzoekers van KU Leuven en Erasmus MC hebben aangetoond dat cellen het verlies van genen op het X-chromosoom kunnen compenseren door de andere kopie van dat gen actiever te maken. Opvallend is dat ...

nieuws.kuleuven.be

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Vincent Pasque @pasquelab.bsky.social · 8d

How cells maintain genetic balance with remarkable precision.

nieuws.kuleuven.be/en/content/2...

How cells maintain genetic balance with remarkable precision

Researchers from KU Leuven and Erasmus MC (the Netherlands) have shown that cells can compensate for the loss of genes on the X chromosome by increasing the expression of the other gene copy. Surprisi...

nieuws.kuleuven.be

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Vincent Pasque @pasquelab.bsky.social · 8d

www.nature.com/articles/s41...

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels - Nature Communications

Here, the authors investigate gene dosage compensation in mouse pluripotent stem cells to better understand the process of X-chromosome upregulation. They report that mammalian cells can sense when segments of one of the two X chromosomes are genetically deleted in cis and compensate gene expression by upregulation in trans.

www.nature.com

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Vincent Pasque @pasquelab.bsky.social · 8d

Excited to share our new paper in Nature Communications @natcomms.nature.com
(www.nature.com/articles/s41...)

We show how cells can sense when individual genes are lost and compensate by upregulating the remaining gene copy.

With Ryan Allsop, Jeffrey Boeren, Beatrice Tan, Joost Gribnau and others.

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Reposted by Vincent Pasque

Vlad Bondarenko @vladbndk.bsky.social · Sep 5

📣 It is my pleasure to announce our recent review with Margherita on the current approaches, challenges, and perspectives in studying human maternal-fetal interface using in vitro models www.cell.com/cell-stem-ce... 🚀✨️

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Vincent Pasque @pasquelab.bsky.social · Sep 3

Exciting postdoc position to study X-chromosome inactivation using stem cell-based embryos models, advanced imaging and single-cell omics at the Pasque lab, University of Leuven – KU Leuven, Belgium. International team, amazing collaborators. Full details: www.kuleuven.be/personeel/jo...

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Vincent Pasque @pasquelab.bsky.social · Sep 3

We are hiring a Lab Technician! Join our lab at the University of Leuven - KU Leuven, working on stem cell biology and epigenetics. Perform key molecular/cell biology techniques and manage lab operations. Full/part-time contract. Apply by Sept 30!
More info: www.kuleuven.be/personeel/jo...

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Vincent Pasque @pasquelab.bsky.social · Jul 7

Exciting Research Professorship Position in Stem Cell and Developmental Biology at the University of Leuven. Amazing research ecosystem, great colleagues, high quality of life, tenure track. For those interested in joining us, please see below:
www.kuleuven.be/personeel/jo...

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Reposted by Vincent Pasque

Ina Sonnen @sonnenlab.bsky.social · Jun 25

It was fun reflecting on how my career path took me from a focus on cancer research to developmental biology, the urge to understand how development and tissue homeostasis work and how my time at the @biozentrum.unibas.ch contributed to this. Thank you, Katrin Bühler-Popowski, for the interview!

Biozentrum, University of Basel @biozentrum.unibas.ch · Jun 25

Since she was a child, Ina Sonnen dreamed of becoming a cancer researcher. Although her academic career took a slightly different path, the topic of cancer has never quite left the Biozentrum alumna. @sonnenlab.bsky.social ‪
@hubrechtinstitute.bsky.social www.biozentrum.unibas.ch/about/alumni...

Childhood dream: Becoming a scientist

Since she was a child, Ina Sonnen dreamed of becoming a cancer researcher. Although her academic career took a slightly different path, the topic of cancer has never quite left the Biozentrum alumna.

www.biozentrum.unibas.ch

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Reposted by Vincent Pasque

Bertie Gottgens @bertiegottgens.bsky.social · Jun 24

Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...

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Reposted by Vincent Pasque

Stanley E. Strawbridge @stanleystrawbridge.bsky.social · Jun 4

1/10🧵 New preprint! 🚀
We built a resource of 20 clonal human naïve pluripotent stem cell lines from 10 blastocysts. Explore embryo-to-embryo and clone-to-clone variation in one place.
👉doi.org/10.1101/2025.06.02.657331

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Vincent Pasque @pasquelab.bsky.social · Jun 24

We are delighted to share our new preprint “X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels”.
biorxiv.org/content/earl...

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Reposted by Vincent Pasque

Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · Jun 23

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

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Reposted by Vincent Pasque

Claire Rougeulle @crougeulle.bsky.social · Jun 18

Join us in the #institutcurie exceptional environment to explore the mysteries of X chromosome regulation in early human development

Rougeulle lab @rougeulle-lab.bsky.social · Jun 13

If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !

Beetween

app.beetween.com

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Vincent Pasque @pasquelab.bsky.social · Jun 3

On a personal note, I feel privileged to have collaborated with her. Her passion and insight continue to motivate us.

Here’s a paper we worked on together - a small part of her big impact: www.nature.com/articles/s41...

Janet, this award is well deserved. Congratulations!

Evaluating totipotency using criteria of increasing stringency - Nature Cell Biology

Posfai, Schell, Janiszewski et al. assess candidate totipotent stem cells with in vitro and in vivo assays of increasing stringency to evaluate their developmental potential and lineage contributions.

www.nature.com

Vincent Pasque @pasquelab.bsky.social · Jun 3

I am delighted to congratulate Janet Rossant on receiving the LSO Lifetime Achievement Award! Janet’s work on early embryos has shaped the field and inspired so many of us.

Here is a wonderful video about Janet and her recent award: www.youtube.com/watch?v=ZZa7...

www.youtube.com

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Reposted by Vincent Pasque

Rougeulle lab @rougeulle-lab.bsky.social · Jun 2

You can follow our team on our new webpage: institut-curie.org/team/rougeulle

Sex chromosomes, development and diseases - Institut Curie

In the Rougeulle lab, we study the emblematic process of X chromosome inactivation. We aim at elucidating how such a chromosome-wide epigenetic silencing is achieved and regulated during early human d...

institut-curie.org

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Reposted by Vincent Pasque

dandergassen.bsky.social @dandergassen.bsky.social · May 2

I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com!
🔗 tinyurl.com/3jkzzy7d

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