Lightnews — Scholar-powered news

Reposted by Claire Rougeulle

Edda Schulz @eddaschulz.bsky.social · 2d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

3 50 100

Reposted by Claire Rougeulle

Jean-Yves Tinevez @jytinevez.bsky.social · 1d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

2 72 56

Reposted by Claire Rougeulle

Nicolas Robine @nicorobine.bsky.social · 20d

"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance"
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...

Transposable elements are vectors of recurrent transgenerational epigenetic inheritance

DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

www.science.org

1 7 17

Reposted by Claire Rougeulle

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · Sep 5

Professor Fuller is brilliant and you need to read what she has to say.

Angie Rasmussen @angierasmussen.bsky.social · Sep 5

If you’re wondering how much of what RFK Jr said yesterday about vaccines was true—almost none of it was.

@FullerLab_UW is one of the most accomplished vaccinologists out there and her article is required reading to separate truth from falsehoods.

theconversation.com/how-rfk-jr-s...

How RFK Jr.’s misguided science on mRNA vaccines is shaping policy − a vaccine expert examines the false claims

Chaos at the CDC and the sharp move away from mRNA vaccines has public health experts alarmed.

theconversation.com

8 20

Reposted by Claire Rougeulle

Institut Curie @institutcurie.bsky.social · Sep 4

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

www.nature.com

6 9

Claire Rougeulle @crougeulle.bsky.social · Sep 4

Congrats Charlène!

Charlène Boumendil (She/Her) @charleneboumendil.bsky.social · Sep 4

I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)

European Research Council (ERC) @erc.europa.eu · Sep 4

📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope

1 1

Reposted by Claire Rougeulle

dfachinetti.bsky.social @dfachinetti.bsky.social · Sep 4

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

www.nature.com

9 35 82

Reposted by Claire Rougeulle

paveltomancak.bsky.social @paveltomancak.bsky.social · Sep 4

We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12)

www.nature.com/articles/s41...
www.nature.com/articles/s41...

Patterned invagination prevents mechanical instability during gastrulation - Nature

In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphog...

www.nature.com

1 10 40

Claire Rougeulle @crougeulle.bsky.social · Sep 1

The @crick.ac.uk is in good hands! Not that it wasn’t before

James Briscoe @jamesbriscoe.bsky.social · Sep 1

Exciting day for @crick.ac.uk today: Edith Heard takes over as Director

We're looking forward to this new chapter in the story

www.crick.ac.uk/about-us/lea...

Edith Heard

www.crick.ac.uk

1 5

Reposted by Claire Rougeulle

Daniel Aldrich @danielaldrich.bsky.social · Aug 29

if you are willing to look clear-eyed at the cumulative evidence, the inescapable conclusion is that our deeply held beliefs about American democracy no longer match our present reality.
donmoynihan.substack.com/p/the-author...

The authoritarian checklist

It is time to admit that America is no longer a functioning democracy

donmoynihan.substack.com

2 23 69

Reposted by Claire Rougeulle

MeidasTouch @meidastouch.com · Aug 27

CHAOS ERUPTS AT CDC

CDC Director Susan Monarez has been ousted after RFK Jr. demanded she change her policy on the COVID vaccine. Top officials from the Vaccine Unit, Zoonotic Division, and the Chief Medical Officer are resigning, per reports.

Horrifying news for public health.

870 3.8K 11K

Reposted by Claire Rougeulle

Scott MacFarlane @macfarlanenews.bsky.social · Aug 28

Sen Patty Murray (D-WA):

“If there are any adults left in the White House, it’s well past time they face reality… We cannot let RFK Jr. burn what’s left of the CDC and our other critical health agencies to the ground—he must be fired.”

410 3.7K 13K

Reposted by Claire Rougeulle

mhverlhac.bsky.social @mhverlhac.bsky.social · Aug 28

Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: [email protected]

25 27

Reposted by Claire Rougeulle

Nature Biotechnology @natbiotech.nature.com · Aug 26

In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...

Children with rare genetic diseases get CRISPR Cures center - Nature Biotechnology

Nature Biotechnology - Children with rare genetic diseases get CRISPR Cures center

www.nature.com

1 14 20

Reposted by Claire Rougeulle

James Gahan @jgahan.bsky.social · Aug 26

Just a few more days left to apply!

James Gahan @jgahan.bsky.social · Jul 16

We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...

6 2

Reposted by Claire Rougeulle

Institut Curie @institutcurie.bsky.social · Aug 26

📅 Apply by Sept 14 to our International Course “Multiscale integration in Biological Systems” in partnership with @normalesup.bsky.social
👉 Open to MSc/PhD students, postdocs & researchers: training.institut-curie.org/courses/mult...

5 2

Reposted by Claire Rougeulle

Maxim Greenberg @maxvcg.bsky.social · Aug 23

Wow, maybe genomic imprinting as we know it is just the tip of then iceberg. Hopefully this helps usher in a wave of mechanistic studies www.nature.com/articles/s41...

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

www.nature.com

2 13 43

Reposted by Claire Rougeulle

Gregg Gonsalves @gregggonsalves.bsky.social · Aug 23

Want to see the impact of #NIH, #NSF and #EPA grant cuts in your community? Check out @noamross.net, @scott-delaney.bsky.social and colleagues' project here. Tell your friends and neighbors about what is happening. grant-witness.us

Grant Witness

grant-witness.us

3 49 90

Claire Rougeulle @crougeulle.bsky.social · Aug 22

Well done Katja!

The EMBO Journal @embojournal.org · Aug 6

Eliminating both #separase inhibition mechanisms –via securin and via cyclin B1-Cdk1– reveals absence of robust cohesin protection in metaphase II #oocytes
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....

1 1

Reposted by Claire Rougeulle

Laura Breimann @laurabreimann.bsky.social · Aug 16

Excited that our paper was published in Science Advances 🧪
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!

The Wyss Institute at Harvard University @wyssinstitute.bsky.social · Aug 15

Wyss researchers have induced human stem cells to initiate meiosis – a key step in creating eggs and sperm – in the lab for the first time. This work was published in @science.org Advances.

Recapitulating egg and sperm development in the dish

By Benjamin Boettner (BOSTON) — More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-q...

wyss.harvard.edu

1 4 13

Reposted by Claire Rougeulle

Bardin Lab @bardinlab.bsky.social · Aug 14

Our institution has given a generous donation as well as our fly labs. Convince yours to do so as well!

Mark A. Hanson @hansonmark.bsky.social · Aug 14

A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.

www.philanthropy.cam.ac.uk/give-to-camb...

5 13

Claire Rougeulle @crougeulle.bsky.social · Aug 14

Congratulations Ohad !

Epigenome Technologies @epigenometech.bsky.social · Aug 4

Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB

Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB

#Epigenetics #Chromatin #Lamin
---

Gain deeper insights into gene regulation; epigenometech.com

The molecular basis of lamin-specific chromatin interactions - Nature Structural & Molecular Biology

Wang, Kronenberg-Tenga, Rosti and colleagues use several structural approaches to analyze the distribution of nucleosomes at the lamin–chromatin interface, test the impact of lamins on nucleosome dens...

go.nature.com

1

Reposted by Claire Rougeulle

Jeremy Berg @jeremymberg.bsky.social · Aug 14

Sign the petition to call for the removal of RFK, Jr.

www.standupforscience.net/rfk-impeachm...

Sign the IMPEACH RFK Citizens' Petition to Congress — STAND UP FOR SCIENCE

Join with us to sign our Citizens' Petition to the US Congress to choose the people over Trump and Impeach RFK Jr Now!

www.standupforscience.net

3 69 130

Reposted by Claire Rougeulle

Sara Wickstrom @sarawickstrom.bsky.social · Aug 1

Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥

EMBL Events @events.embl.org · Jul 31

📢 Abstract submission deadline reminder for 'Cell biology of the nucleus'!

Before packing your bags and leaving for your summer vacation, there is one important task left to do: submit your abstract for #EESNucleus ✍️

Deadline is 26 August: https://s.embl.org/ees25-07-bl

16 28

Reposted by Claire Rougeulle

Maxim Greenberg @maxvcg.bsky.social · Aug 6

Really beautiful work led by Jessica Leismann in Joan Barau’s lab @imbmainz.bsky.social . If you like elegant mouse genetics, the transposon arms race, and a healthy dose of epigenetics, this one’s for you. www.embopress.org/doi/full/10.... @emboreports.org

DNA methylation at retrotransposons protects the germline by preventing NRF1-mediated activation | EMBO reports

imageimageIn spermatogenesis, loss of promoter DNA methylation reactivates retrotransposons in patterns shaped by chromatin modifications and the binding of DNA methylation-sensitive transcription fac...

www.embopress.org

1 23 51