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Reposted by Patrick Pausch

Jörg Vogel @jorg-vogel-lab.bsky.social · 13h

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

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Erin Doherty @erinedoherty.bsky.social · 7d

Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.

Check out this work co-led with @benadler.bsky.social here:

www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Jerrin Thomas George @jerrintgeorge.bsky.social · 10d

I am happy to share our work on the mechanism of prokaryotic immunity by a reverse transcriptase associated with an SMC-family ATPase, now published in @natcomms.nature.com
🔗 nature.com/articles/s4146…
(🧵 on the bioRxiv version ⬇️)

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Milan Gerovac @gerovac.bsky.social · 28d

No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com

Programmable antisense oligomers for phage functional genomics - Nature

Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...

www.nature.com

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Jörg Vogel @jorg-vogel-lab.bsky.social · 28d

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

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Patrick Pausch @patrick-pausch.bsky.social · Sep 5

The cat is out of the bag! Congrats ;) 🥳

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Patrick Pausch @patrick-pausch.bsky.social · Sep 5

Congrats, Jens! 💪

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Patrick Pausch @patrick-pausch.bsky.social · Sep 5

Awesome!!! Congrats! 🍻

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Constantinos Patinios @copabio.bsky.social · Sep 4

🚀 New publication alert! 🚀

We just published in @natbiotech.nature.com:
👉 Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
doi.org/10.1038/s415...

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature Biotechnology

Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.

doi.org

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Erin Doherty @erinedoherty.bsky.social · Aug 22

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

Divergent viral phosphodiesterases for immune signaling evasion

Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...

www.biorxiv.org

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Itai Yanai @itaiyanai.bsky.social · Jul 29

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

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Patrick Pausch @patrick-pausch.bsky.social · Jul 25

Congrats and good luck with your start! 🥳

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Martin Pacesa @martinpacesa.bsky.social · Jul 25

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

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Kranzusch Lab @kranzuschlab.bsky.social · Jul 17

A new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity.

www.biorxiv.org/content/10.1...

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Martin Pacesa @martinpacesa.bsky.social · Jun 30

We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!

github.com/martinpacesa...

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giedriussasnauskas.bsky.social @giedriussasnauskas.bsky.social · Jun 13

'Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation'
Check out our preprint on #bioRxiv on the #Cas9-Cas1-Cas2-Csn2 supercomplex involved in #CRISPR spacer acquisition: www.biorxiv.org/cgi/content/...
Thread below.

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Patrick Pausch @patrick-pausch.bsky.social · Jun 3

- We stand with Ukraine - 🇺🇦

Due to the ongoing war of aggression against Ukraine, we offer travel grants to Ukrainian researchers affected by the war. If you have been affected by the war, please reach out to the Organising Committee for travel support. #ScienceForUkraine

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Patrick Pausch @patrick-pausch.bsky.social · Jun 3

PhDs, Postdocs and young PIs listen up!

Next to connecting young scientists, we organised an engaging Night Science 💫 workshop (by @itaiyanai.bsky.social and Martin Lercher), and an epic social event at one of Vilnius’ best venues 🍻 .

EMBO @embo.org · Jun 2

This year's EMBO Young Scientists’ Forum (EYSF) will take place in Vilnius, LT from 24–26 Sep 2025. The EYSF brings together scientists across #Europe for #networking and scientific exchange – Apply now! 🧪

Abstract submission by 1 Aug
Registration by 15 Aug

meetings.embo.org/event/25-eysf

EMBO Young Scientists’ Forum 2025

The EMBO Young Scientists’ Forum (EYSF) brings together young scientists (doctoral and postdoctoral) to engage with colleagues from across the continent and share their findings and interests with it…

meetings.embo.org

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EMBO @embo.org · Jun 2

This year's EMBO Young Scientists’ Forum (EYSF) will take place in Vilnius, LT from 24–26 Sep 2025. The EYSF brings together scientists across #Europe for #networking and scientific exchange – Apply now! 🧪

Abstract submission by 1 Aug
Registration by 15 Aug

meetings.embo.org/event/25-eysf

EMBO Young Scientists’ Forum 2025

The EMBO Young Scientists’ Forum (EYSF) brings together young scientists (doctoral and postdoctoral) to engage with colleagues from across the continent and share their findings and interests with it…

meetings.embo.org

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Rafal Mostowy @rafalmostowy.bsky.social · May 20

I'm looking for a postdoc in computational evolutionary phage genomics, with the goal to better understand how protein innovation arises in viruses, at @jagiellonskiuni.bsky.social in Krakow (Poland).

Drop me a line if it sounds cool!

Deadline: 20.06.

Link here:
mcb.uj.edu.pl/documents/15...

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Sebastian Glatt @sebastianglatt.bsky.social · Apr 30

We are very excited about our latest work, which just came out @embojournal.org – www.embopress.org/doi/full/10..... The work @MCB_UJ was driven by Anna Biela and Ting-Yu Lin 林亭妤 in collaboration with @jmbujnicki.bsky.social…a short🧵

Determining the effects of pseudouridine incorporation on human tRNAs | The EMBO Journal

imageimagetRNAs harbour a complex set of modifications which are important for their function. Here, single particle cryo-EM, biophysics, and computational analyses of the effects of pseudouridine inc...

www.embopress.org

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Alexander Harms @aharms485.bsky.social · Apr 8

And here it is, the completed BASEL collection finally published as early access in @plosbiology.org - see the thread for more details. 🤗🧬🎣

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Gemma C. Atkinson @gemmaatkinson.bsky.social · Mar 19

Please spread the word! We have an opening in the Atkinson lab for a post-doc with a focus on the molecular mechanisms of microbial immune systems. Can be a fully computational or experimental or hybrid project.

Read more and apply here:
lu.varbi.com/en/what:job/...
#phage #bioinformatics

Postdoctoral research fellow with a focus on the molecular mechanisms of bacteriophage-host interactions

Description of the Workplace In the Atkinson lab we are interested in making discoveries about protein function and structure, with a focus on bacterial immune system components that protect against b

lu.varbi.com

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Itai Yanai @itaiyanai.bsky.social · Mar 7

Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse!
Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...

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Cress Lab @cresslab.bsky.social · Feb 26

Dive into our lab’s first peer-reviewed publication—co-led with our friends @benadler.bsky.social and Muntathar Al-Shimary from the @doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s415... @naturemicrobiol.bsky.social

CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d - Nature Microbiology

Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.

doi.org

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