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Reposted by paulo angelo

Tuba Zef

@tubazef.com

Artigo publicado dia 23, qdo é noticia ruim todo mundo fica sabendo na hora né??
Espalhem coisas boas tbm!

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

Highlights
•Severity of Alzheimer's disease (AD) correlates with
NAD+ homeostasis dysregulation
•Preserving brain NAD+ homeostasis prevents AD in mice
• Restoring brain NAD+ homeostasis reverses advanced
AD in mice
• Multiomics across human and mouse AD brain identifies nodes for human AD reversal
Summary
Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases.
In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible.

Abstract
Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217.
P7C3-A20 also reverses advanced disease in tau-driven
PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

Graphical Abstract (CREDIT: Cell Reports Medicine)

December 28, 2025 at 8:47 PM

Reposted by paulo angelo

Ditados Mashup Bot

@ditados.bsky.social

Pau que bate em chico não vê coração

December 26, 2025 at 7:44 PM

Reposted by paulo angelo

Quest 64 Official

@quest64official.bsky.social

December 25, 2025 at 11:06 PM

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Dalahai

@dalahai.bsky.social

:) happy crismz

December 25, 2025 at 3:10 AM

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mae

@mae.seal.observer

the wave of beedrill posting keeps making me think of this classic

December 22, 2025 at 1:58 AM

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Ieda Marcondes

@iedamarcondes.com

Todo dia agora é "Senado irá votar PL que libera chutar cachorro", "Senado aprova o retorno do mertiolate que arde", "Senado quer acordo para não aprovar a proibição do cinto de segurança"

Eixo Político @eixopolitico.com.br · 13d

🇧🇷 Além do projeto da dosimetria, Senado pode votar ainda hoje a LIBERAÇÃO de CASSINOS no Brasil.

December 17, 2025 at 10:36 PM

Reposted by paulo angelo

corrimento esbranquiçado tão forte que já vai leitando o cu

@subacofeminino.bsky.social

o cara do Corolla Xei mitando de novo

December 10, 2025 at 7:07 PM

Reposted by paulo angelo

Tuba Zef

@tubazef.com

"Gente, viram que absurdo? O Kim Jong Un criou um premio da paz pra dar pra ele mesmo!"

December 5, 2025 at 5:46 PM

Reposted by paulo angelo

Yo red🇵🇸🍉

@yoredantesyogren.bsky.social

😭😂🤣😂😭

December 2, 2025 at 7:35 PM

Reposted by paulo angelo

Felippe Katan

@felippekatan.bsky.social

Sendo que beneficia quem ganha até R$ 7.350, né..

Se você recebe mais do que 90% da população e tá reclamando, desejo que vá tomar no cu

Se você recebe mais que 99% da população, vai ter aumento de imposto e tá reclamando, a Jay vai me banir se eu falar o que desejo

Paola Costa @paoladcs.bsky.social · Nov 26

Sancionada a lei que isenta quem ganha até 5k por mês de Imposto de Renda

"Ai mas não me beneficia"

Parabéns por ser parte dos 16% dos trabalhadores brasileiros com renda acima de 5k mensal. Quer um biscoito?

November 26, 2025 at 7:29 PM

Reposted by paulo angelo

Tuba Zef

@tubazef.com

To all the bozos complaining about woman and minorities joining games just recently and it being too woke now: Rebecca Heineman and her wife, Jennell Jaquays, have been in the games industry since the early 80s. Video games wouldn't exist without LGBTQ+ people, this shit was woke from the beginning

November 18, 2025 at 4:31 PM

Reposted by paulo angelo

Ursula Dorada

@sulamoon.bsky.social

Me perguntaram no Instagram
Pq desenhar em época de IA?

November 19, 2025 at 3:19 AM

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Ditados Mashup Bot

@ditados.bsky.social

Pau que bate em Chico tem medo de água fria

November 16, 2025 at 11:44 PM

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Ditados Mashup Bot

@ditados.bsky.social

Pau que bate em Chico seus males espanta

November 15, 2025 at 1:44 AM

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Ditados Mashup Bot

@ditados.bsky.social

Quem não chora à casa torna

November 13, 2025 at 7:44 AM

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Ditados Mashup Bot

@ditados.bsky.social

Mente vazia tanto bate até que fura

November 11, 2025 at 9:44 PM

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Eyepatch Wolf

@eyepatchwolf.bsky.social

“0% woke shit”

a black man with a physical disability leads an environmental terrorist cell trying to save the planet from mega-billionaires and you play as a cross dressing twink femdomed by two different women ending and the final boss against the gayest angel of all time