Lightnews — Scholar-powered news

Peng Wu @pengwu.bsky.social · Aug 31

This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy

SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-CD19...

www.cell.com

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Peng Wu @pengwu.bsky.social · Aug 27

Octopus 🐙😋

Reposted by Peng Wu

Adrian Liston @labliston.bsky.social · Aug 11

T cells fast-track gut signals to the brain

Nature Immunology - CD4+ T cells migrate from the gut and adipose tissue to the brain parenchyma, in mouse and human, transmitting information on diet and microbiome to the subfornical organ,...

rdcu.be

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Peng Wu @pengwu.bsky.social · Jun 23

Here is the bottle 😄

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Peng Wu @pengwu.bsky.social · Jun 23

I inherited a huge bottle of GDP-fucose from the Paulson lab today, thanks Jim! # glycotime

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Peng Wu @pengwu.bsky.social · Jun 17

In this incredible work, @srouhanifard.bsky.social developed a new catalyst, which makes CuAAC truly biocompatible
rdcu.be/enfHz

inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst

Nature Communications - Tracking biomolecules in living cells requires fast but gentle labeling. Here, authors introduce inCu-click, a DNA-conjugated ligand that localizes copper to enable...

rdcu.be

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Peng Wu @pengwu.bsky.social · Jun 3

The Rabinovichlab discovered that MDSC-specific deletion of ST6Gal1 enhanced GAL1-driven suppressive signals and accelerated tumor growth, effects that can be ameliorated by GAL1-blocking antibodies www.cell.com/immunity/ful...

Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

Blidner et al. identify a glycosylation-dependent, galectin-driven circuit as a common mechanism that simultaneously induces immunosuppressive and pro-angiogenic functions in myeloid-derived suppresso...

www.cell.com

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Peng Wu @pengwu.bsky.social · Jun 3

Such an inspiring talk by Dr. Rabinovich #Glyco27 on the immuno-modulatory functions of galectins #immunotherapy

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Peng Wu @pengwu.bsky.social · May 16

The 33rd commencement at Scripps starts now

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Peng Wu @pengwu.bsky.social · May 1

Congratulations to Ellie for successfully defending her Ph.D. Her thesis work provided new insights into the inhibitory interactions between sialoglycans and SIglecs #glycotime We are so proud of you!

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Reposted by Peng Wu

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 30

“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.”

www.nytimes.com/2025/04/28/o...

Opinion | The White House Tech Bros Owe Their Fortunes to the Research They’re Killing

Underlying many investments are breakthroughs in medicine and technology from great universities.

www.nytimes.com

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Reposted by Peng Wu

Elisa Fadda @elisafadda.bsky.social · Apr 3

#glycotime "OGT protects the genome against TET-mediated DNA demethylation and loss of heterochromatin integrity, preventing the aberrant increase in transposable element expression noted in cancer, autoimmune-inflammatory diseases, cellular senescence and aging" www.nature.com/articles/s41...

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide - Nature Structural & Molecular Biology

Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos...

www.nature.com

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Peng Wu @pengwu.bsky.social · Apr 1

It’s nice meet to meet with @roviralab.bsky.social to discuss our fucosylation enzymes. Thank you for your kind host!

RoviraLab @roviralab.bsky.social · Apr 1

Thank you so much @pengwu.bsky.social for taking time to visit us at @ub.edu! We appreciate your insight and discussions on protein glycosylation mechanisms.
@scripps.edu

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Reposted by Peng Wu

Joshua Weitz @joshuasweitz.bsky.social · Mar 28

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.

Find out how your community may be impacted.

Explore more at SCIMaP: scienceimpacts.org

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US map via scienceimpacts.org visualization of economic loss due to IDC cuts to 15% as part of Feb 7, 2025 executive order, with shading denoting intensity of cuts.

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Peng Wu @pengwu.bsky.social · Mar 28

@rpdevrieslab.bsky.social fantastic work on the involvement of the LacNAc chains in human influenza A virus hemaglutinin receptor interactions #glycotime rdcu.be/dD4Q0

Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling

Nature Communications - Binding modes of antigenically drifted hemagglutinins of human influenza A viruses have been determined by NMR using synthetic N-glycans having 13C-labeled monosaccharides...

rdcu.be

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Peng Wu @pengwu.bsky.social · Mar 28

Excellent news!

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Mar 28

Now we’re finally talking!

www.politico.com/news/2025/03...

www.politico.com

Peng Wu @pengwu.bsky.social · Mar 27

Stromal cell sialylation suppresses NK cell function through Siglec-10 engagement #glycotime www.biorxiv.org/content/10.1...

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis

The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...

www.biorxiv.org

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Peng Wu @pengwu.bsky.social · Feb 25

Musk is not here, please post on X 🤗

Reposted by Peng Wu

Jeremy Baskin @jeremybaskin.bsky.social · Feb 19

Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social

ChemKritzer @chemkritzer.bsky.social · Feb 19

🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.

If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩‍🔬

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Reposted by Peng Wu

John Yates @jyates.bsky.social · Feb 20

www.theatlantic.com/health/archi...

The NIH Memo That Undercut Universities Came Directly From Trump Officials

NIH officials said they were given no advance warning and less than an hour to post the memo publicly.

www.theatlantic.com

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Reposted by Peng Wu

Jonathan Kagan @jkagan1.bsky.social · Feb 15

If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus?
www.nytimes.com/2025/02/14/o...

Opinion | American Science is Under Attack (Gift Article)

The Trump administration hobbles research and endangers the public health.

www.nytimes.com

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Peng Wu @pengwu.bsky.social · Feb 14

Look forward to speak at the 2025 Carbohydrate GRC #glycotime

Jennifer Kohler @doctorjj.bsky.social · Feb 14

Registration is open for the 2025 Gordon Research Conference on Carbohydrates and the associated Gordon Research Seminar! 🧪 We have a exciting line-up of confirmed speakers and more to be added!
www.grc.org/carbohydrate...
The conference will be held June 15 - 20 in Holderness, NH.

2025 Carbohydrates Conference GRC

The 2025 Gordon Research Conference on Carbohydrates will be held in Holderness, New Hampshire. Apply today to reserve your spot.

www.grc.org

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Reposted by Peng Wu

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 8

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.

www.washingtonpost.com/health/2025/...

NIH cuts billions of dollars in biomedical funding, effective immediately

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

www.washingtonpost.com

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Peng Wu @pengwu.bsky.social · Feb 4

Many people do not even disclose construct seq for antibodies and CARs.

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Peng Wu @pengwu.bsky.social · Feb 3

Enhancing glycosylation levels is good for CAR-T, maintaining their anti-tumor efficacy without causing GvHD #glycotime

Changes in Glycosylation on the Cell Surface Result in Highly Potent and Long-Lasting Allogeneic CAR-T Therapy in Patients

Disclosures. No relevant conflicts of interest to declare.

ashpublications.org

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