platorremuro.bsky.social
Pedro Latorre-Muro
@platorremuro.bsky.social
39 followers 48 following 5 posts
Scientist. Veterinarian. Spaniard. Curiosity drives change. Instructor DFCI_CancerBio & HarvardCellBio. K99 Awardee NIDDK. Previous HFSP fellow.
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platorremuro.bsky.social
Pedro Latorre-Muro @platorremuro.bsky.social · Feb 17
Congrats!
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Reposted by Pedro Latorre-Muro
hagesprenger.bsky.social
HaGe Sprenger @hagesprenger.bsky.social · Feb 17
Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social

Thanks to everyone involved!

www.cell.com/cell-metabol...
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Reposted by Pedro Latorre-Muro
natcellbio.nature.com
Nature Cell Biology @natcellbio.nature.com · Jan 31
💫NEW by @ppuigserverb.bsky.social & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice.
👉https://rdcu.be/d8atv
www.nature.com/articles/s41...
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity - Nature Cell Biology
Latorre-Muro et al. show that the cytosolic chaperone PPID drives insertion of the mitochondrial import receptor TOM70 into the mitochondrial outer membrane, thereby regulating body temperature, gluco...
www.nature.com
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platorremuro.bsky.social
Pedro Latorre-Muro @platorremuro.bsky.social · Jan 24
Very exciting findings @ppuigserverb.bsky.social connect mitochondrial ETC deficiencies with cancer cell immunogenicity expanding the repertoire of strategies to target tumor vulnerabilities
natcancer.nature.com
Nature Cancer @natcancer.nature.com · Jan 24
Online now!

Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.

👇
www.nature.com/articles/s43...
Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer
Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...
www.nature.com
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Reposted by Pedro Latorre-Muro
ppuigserverb.bsky.social
Puigserver Lab @ppuigserverb.bsky.social · Jan 17
New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ
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Reposted by Pedro Latorre-Muro
ppuigserverb.bsky.social
Puigserver Lab @ppuigserverb.bsky.social · Jan 17
Thanks to Désirée Schatton and Christian Frezza @frezzalab.bsky.social for the great News and Views @naturecancer.bsky.social
www.nature.com/articles/s43...
Fine-tuning tumor immunogenicity with mitochondrial complex I - Nature Cancer
Targeting mitochondrial metabolic activity is an active area of cancer research. A study now finds that a selective deficiency in mitochondrial complex I in melanoma cells increases mitochondrial acet...
www.nature.com
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platorremuro.bsky.social
Pedro Latorre-Muro @platorremuro.bsky.social · Jan 4
Thanks, Melanie!
platorremuro.bsky.social
Pedro Latorre-Muro @platorremuro.bsky.social · Jan 3
Thanks, HaGe!
platorremuro.bsky.social
Pedro Latorre-Muro @platorremuro.bsky.social · Jan 3
Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders
ppuigserverb.bsky.social
Puigserver Lab @ppuigserverb.bsky.social · Jan 3
New article by @platorremuro.bsky.social published in @naturecellbiology.bsky.social Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity- With Kajimura, Gygi and Eck labs @danafarber.bsky.social @harvardcellbio.bsky.social
rdcu.be/d5ptF
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Reposted by Pedro Latorre-Muro
nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · Dec 31
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
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Reposted by Pedro Latorre-Muro
ppuigserverb.bsky.social
Puigserver Lab @ppuigserverb.bsky.social · Dec 19
Our recent work on mitochondrial respiratory complexes @platorremuro.bsky.social highlighted in the DFCI Inside blog- Thanks to the Dana-Farber Editorial team for written this blog @danafarber.bsky.social
blog.dana-farber.org/insight/2024...
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Reposted by Pedro Latorre-Muro
ppuigserverb.bsky.social
Puigserver Lab @ppuigserverb.bsky.social · Nov 18
In the latest issue of Cell- Structural basis of respiratory complex adaptation to cold temperatures
Structural basis of respiratory complex adaptation to cold temperatures
High-resolution structures of respiratory I:III2 complexes from brown fat adapted to cold temperatures reveal a distinct supercomplex assembly with rotated CIII2 that displays higher electron transfer...
www.cell.com
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