nilsburger.bsky.social
Nils Burger
@nilsburger.bsky.social
730 followers 670 following 10 posts
Assistant Professor at UTSW Medical Center Postdoc Chouchani Lab at Dana-Farber Cancer Institute and Harvard Medical School | PhD University of Cambridge - Murphy Lab MRC Mitochondrial Biology Unit
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Nils Burger @nilsburger.bsky.social · Dec 31
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · 7d
Sounds great looking forward to it!
nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · 7d
I will be hiring on all levels; posts following shortly. Please reach out if you know talented scientists who would like to join me in Dallas.
Stay tuned for job posts and future updates!
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · 7d
The Burger Lab will leverage mass spectrometry and systems-based strategies to study how redox processes and metabolism regulate the proteome and cellular function in health and disease. www.nils-burger-lab.com
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · 7d
Excited to share that I’ve started my lab as an assistant professor at the University of Texas Southwestern Medical Center in Dallas.

Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
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Reposted by Nils Burger
haopengxiao.bsky.social
Haopeng Xiao @haopengxiao.bsky.social · 20d
We are seeking a life science research professional/technician (medcareers.stanford.edu/job/stanford...) and a postdoctoral fellow(postdocs.stanford.edu/prospective/...). If you are interested in using mass spec and machine learning to understand protein function and druggability please reach out!
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · 20d
Fantastic story by Haopeng Xiao, the Chouchani Lab, and collaborators. Happy I could be a part of it!
haopengxiao.bsky.social
Haopeng Xiao @haopengxiao.bsky.social · 20d
We developed a MS and machine learning approach to globally identify protein regulators of metabolism. We found protein LRRC58 controls cellular cysteine catabolism by mediating degradation of CDO1, the rate-limiting enzyme of the catabolic cysteine shunt to taurine. www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
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Reposted by Nils Burger
mellimittenblr.bsky.social
Melanie Mittenbühler @mellimittenblr.bsky.social · Jul 30
‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.

ddz.de/job/postdoct...

ddz.de/en/research/...
Postdoctoral Researcher (Ph.D./Dr. rer. nat., m/f/div., E13 TV-L, 100%) - Deutsches Diabetes-Zentrum (DDZ)
Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)
ddz.de
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Reposted by Nils Burger
cochemelab.bsky.social
Helena Cocheme @cochemelab.bsky.social · Jun 27
🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
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Reposted by Nils Burger
mitoredox.bsky.social
Mike Murphy @mitoredox.bsky.social · Apr 9
Important new paper in Nature from Gero Miesenböck's lab showing that the accumulation of lipid peroxidation products from mitochondrial ROS production leads in sleep.

doi.org/10.1038/s415...
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature
Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...
doi.org
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · Feb 19
Big congrats Alva and Mike!!
Reposted by Nils Burger
hagesprenger.bsky.social
HaGe Sprenger @hagesprenger.bsky.social · Feb 17
Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social

Thanks to everyone involved!

www.cell.com/cell-metabol...
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · Feb 17
Big congrats HaGe, Melanie and Bruce!
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mellimittenblr.bsky.social
Melanie Mittenbühler @mellimittenblr.bsky.social · Feb 13
Very happy to share that my research group has launched at the German Diabetes Center (DDZ) in Düsseldorf!

We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!

ddz.de/en/job/docto...
Doctoral Student (PhD/Dr. rer. nat., m/f/div., E13 TV-L 65%) - Deutsches Diabetes-Zentrum (DDZ)
A job-opening of the German Diabetes-Center (DDZ). (24681)
ddz.de
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Reposted by Nils Burger
ryanlab.bsky.social
RyanLab_TCD @ryanlab.bsky.social · Jan 10
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫

**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**

#mitochondria #immunometabolism #macrophages

📄Read here: www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses[1][1]–[6][2], but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we a...
www.biorxiv.org
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Reposted by Nils Burger
ppuigserverb.bsky.social
Puigserver Lab @ppuigserverb.bsky.social · Jan 17
New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ
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Reposted by Nils Burger
ryanlab.bsky.social
RyanLab_TCD @ryanlab.bsky.social · Jan 6
📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...
www.biorxiv.org
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Reposted by Nils Burger
platorremuro.bsky.social
Pedro Latorre-Muro @platorremuro.bsky.social · Jan 3
Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders
ppuigserverb.bsky.social
Puigserver Lab @ppuigserverb.bsky.social · Jan 3
New article by @platorremuro.bsky.social published in @naturecellbiology.bsky.social Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity- With Kajimura, Gygi and Eck labs @danafarber.bsky.social @harvardcellbio.bsky.social
rdcu.be/d5ptF
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · Dec 31
And of course, thanks to the great scientific environment and support!
@danafarber.bsky.social @danafarbernews.bsky.social @harvardcellbio.bsky.social @harvardmed.bsky.social @dfgpublic.bsky.social @hhmi.bsky.social
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · Dec 31
Great thanks to all my amazing collaborators and friends who helped to make this work possible! Some of which are already on Bluesky!
@mellimittenblr.bsky.social @platorremuro.bsky.social @sepidehmehravar.bsky.social @petrocellijj.bsky.social @hagesprenger.bsky.social @amandalsmythers.bsky.social
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nilsburger.bsky.social
Nils Burger @nilsburger.bsky.social · Dec 31
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
6 12 43