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Reposted by Puigserver Lab

Daniel Drucker @danieljdrucker.bsky.social · Jul 14

PGC-1α–mediated phospholipid synthesis plays a pivotal role in BAT thermogenesis in a sex-dependent manner in mice revealing a new therapeutic target for metabolic diseases in postmenopausal women. www.nature.com/articles/s41...

Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice - Nature Communications

Brown adipose tissue (BAT) plays a role in energy expenditure but its thermogenic activities differ between sexes. Here, the authors show that PGC-1α enhances mitochondrial function and BAT thermogene...

www.nature.com

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Puigserver Lab @ppuigserverb.bsky.social · Jul 10

Thanks, Tom and Jonathan!
‪@danafarber.bsky.social‬
‪@harvardcellbio.bsky.social‬

Puigserver Lab @ppuigserverb.bsky.social · Jul 3

New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency.

t.co/m71gz29mUv

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Nature Cancer @natcancer.nature.com · Jun 4

📢Article now online at Nature Cancer!

'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia'

✏️By Young-Mee Kim, Jalees Rehman and colleagues

🔗 www.nature.com/articles/s43...

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer

Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

www.nature.com

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Daniel Drucker @danieljdrucker.bsky.social · May 26

A vascular perspective on #cancer cachexia here restoring endothelial PGC1α activity preserved vascular density and muscle mass in tumor-bearing mice @natcancer.nature.com www.nature.com/articles/s43...

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer

Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

www.nature.com

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Cell Metabolism @cp-cellmetabolism.bsky.social · Feb 17

Online now: RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

Dumesic et al. identify RBM43 as an RNA-binding protein that governs mitochondrial biogenesis through suppression of PGC1α translation. RBM43 is induced by inflammatory signaling and controls a diabetogenic regulatory axis in adipocytes whereby decreased…

dlvr.it

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Francisca Vazquez PhD @vazquezf.bsky.social · Feb 6

(1/3) Excited to share our latest work using
@depmap.org to uncover a new synthetic lethality in two distinct patient populations!

We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO

#CancerResearch #SyntheticLethality #Genomics #DepMap

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature

Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

nature.com

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The Cancer Dependency Map @depmap.org · Feb 5

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature

Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

www.nature.com

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Puigserver Lab @ppuigserverb.bsky.social · Jan 31

@danafarber.bsky.social @harvardcellbio.bsky.social @danafarbernews.bsky.social

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Nature Cell Biology @natcellbio.nature.com · Jan 31

💫NEW by @ppuigserverb.bsky.social & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice.
👉https://rdcu.be/d8atv
www.nature.com/articles/s41...

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity - Nature Cell Biology

Latorre-Muro et al. show that the cytosolic chaperone PPID drives insertion of the mitochondrial import receptor TOM70 into the mitochondrial outer membrane, thereby regulating body temperature, gluco...

www.nature.com

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Puigserver Lab @ppuigserverb.bsky.social · Jan 29

We are looking for candidates with backgrounds in immunology, ideally with experience in multicolor FACS and single cell methods to complement our deep knowledge of cancer metabolism. More information about us can be found on our website: puigserver.dfci.harvard.edu (2/2)

Puigserver Laboratory

Puigserver Lab’s research has identified new basic and evolutionary-conserved metabolic circuitries which, when dysregulated, represent therapeutic targets for metabolic disorders, cancer, and age-ass...

puigserver.dfci.harvard.edu

Puigserver Lab @ppuigserverb.bsky.social · Jan 29

We are hiring! After the publication of our last paper, our lab has openings for #postdoc fellows in projects looking at the interactions between tumor metabolism and immunology. Direct inquiries to [email protected]. Please share! (1/2)

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Pedro Latorre-Muro @platorremuro.bsky.social · Jan 24

Very exciting findings @ppuigserverb.bsky.social connect mitochondrial ETC deficiencies with cancer cell immunogenicity expanding the repertoire of strategies to target tumor vulnerabilities

Nature Cancer @natcancer.nature.com · Jan 24

Online now!

Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.

👇
www.nature.com/articles/s43...

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer

Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...

www.nature.com

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Puigserver Lab @ppuigserverb.bsky.social · Jan 24

@ppuigserverb.bsky.social‬ @danafarber.bsky.social @harvardcellbio.bsky.social

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Nature Cancer @natcancer.nature.com · Jan 24

Online now!

Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.

👇
www.nature.com/articles/s43...

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer

Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...

www.nature.com

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Reposted by Puigserver Lab

Payam Gammage @mito-oncogene.bsky.social · Jan 17

Really cool work from @ppuigserverb.bsky.social lab! Further strengthening the emerging links between perturbed bioenergetics and effectiveness of immunotherapy 👌👍

Puigserver Lab @ppuigserverb.bsky.social · Jan 17

New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ

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Protein and veg and fasting. @mccheapo.bsky.social · Jan 17

#mitochondria #cancer #keto

Puigserver Lab @ppuigserverb.bsky.social · Jan 17

Thanks to Désirée Schatton and Christian Frezza @frezzalab.bsky.social for the great News and Views @naturecancer.bsky.social
www.nature.com/articles/s43...

Fine-tuning tumor immunogenicity with mitochondrial complex I - Nature Cancer

Targeting mitochondrial metabolic activity is an active area of cancer research. A study now finds that a selective deficiency in mitochondrial complex I in melanoma cells increases mitochondrial acet...

www.nature.com

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Reposted by Puigserver Lab

Waggoner Lab @labwaggoner.bsky.social · Jan 19

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity
www.nature.com/articles/s43...
@ppuigserverb.bsky.social @naturecancer.bsky.social
www.nature.com/articles/s43...

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer

Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...

www.nature.com

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Puigserver Lab @ppuigserverb.bsky.social · Jan 18

Thanks!

Puigserver Lab @ppuigserverb.bsky.social · Jan 17

Thanks, HaGe!

Puigserver Lab @ppuigserverb.bsky.social · Jan 17

Thanks Payam!

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Puigserver Lab @ppuigserverb.bsky.social · Jan 17

Thanks for the News!

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Puigserver Lab @ppuigserverb.bsky.social · Jan 17

Thanks Christian!

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Reposted by Puigserver Lab

Christian Frezza @frezzalab.bsky.social · Jan 17

Fine-tuning tumor immunogenicity with mitochondrial complex I

Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!

www.nature.com/articles/s43...

www.nature.com

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Puigserver Lab @ppuigserverb.bsky.social · Jan 17

Thanks to Désirée Schatton and Christian Frezza @frezzalab.bsky.social for the great News and Views @naturecancer.bsky.social
www.nature.com/articles/s43...

Fine-tuning tumor immunogenicity with mitochondrial complex I - Nature Cancer

Targeting mitochondrial metabolic activity is an active area of cancer research. A study now finds that a selective deficiency in mitochondrial complex I in melanoma cells increases mitochondrial acet...

www.nature.com

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