Lightnews — Scholar-powered news

Reposted by Pradeep Natarajan

gVasc research study @gvascstudy.bsky.social · 19d

What is spontaneous coronary artery dissection (SCAD)? ♥️💬 Watch as Drs. Mark Lindsay, Tiffany Bellomo, and Pradeep Natarajan share information about this condition.

gvascstudy.org

#SCAD #genetics #scadgenetics @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

1 2 6

Reposted by Pradeep Natarajan

Satoshi Koyama @skoyama.bsky.social · 6d

Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.

3 5 18

Reposted by Pradeep Natarajan

gVasc research study @gvascstudy.bsky.social · Aug 26

How do you join the gVasc Research Study? Visit gvascstudy.org 💻 and follow these easy steps! Complete a few short surveys about your health and receive the saliva kit in the mail 📝 📦 ❤️ #scad #heartresearch #scadalliance @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social

2 4

Reposted by Pradeep Natarajan

gVasc research study @gvascstudy.bsky.social · Aug 26

In the Summer we usually slow down… 🏖️ but here are some Fast Facts ⏱️🗒️ about spontaneous coronary artery dissection (SCAD). Visit gvascstudy.org to learn more about the gVasc study today🫀 #SCAD #heartresearch #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

2 4

Reposted by Pradeep Natarajan

gVasc research study @gvascstudy.bsky.social · Aug 26

Meet the Team! 🩺 gVasc investigators have extensive experience in cardiovascular disease and genetics🫀🧬 They bring together their expertise to uncover the genetic underpinnings of SCAD 🔍 gvascstudy.org #SCAD #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

3 8

Reposted by Pradeep Natarajan

gVasc research study @gvascstudy.bsky.social · Aug 12

gVasc is a research study trying to find out if there are genetic factors behind why SCAD happens🫀Click the link in our bio or head to gvascstudy.org to learn more about our study and to participate! #gvasc #SCAD #research #heart #hearthealth #heartresearch #scadalliance @scadalliance.bsky.social

image of heart - Spontaneous Coronary Artery Dissection - SCAD - gVasc Research Study

3 4

Reposted by Pradeep Natarajan

JAMA @jama.com · Aug 15

🗓️ At #CSANZ2025? JAMA Associate Editors @rohankhera.bsky.social‬, MD, MS and @pnatarajanmd.bsky.social, MD, MMSc, will be at Plaza 4 today, Saturday, August 16 from 3 PM to 3:30 PM.

➡️ Stop by to ask questions
➡️ Learn about publishing opportunities

@cardiacsociety.bsky.social

4 7

Pradeep Natarajan @pnatarajanmd.bsky.social · Jul 28

Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social

1 4 7

Pradeep Natarajan @pnatarajanmd.bsky.social · Jul 21

New polygenic risk score for obesity predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s41... @natureportfolio.nature.com
My comments in @nytimes.com nytimes.com/2025/07/21/h...

Polygenic prediction of body mass index and obesity through the life course and across ancestries - Nature Medicine

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to a...

nature.com

5

Reposted by Pradeep Natarajan

Mike Inouye @mikeinouye.bsky.social · Jul 18

Should I tell anyone that I suspect misconduct in a paper I’m reviewing?

So important and with more ECRs reviewing this guidance is very welcome.

Things to keep in mind:
- Extend the benefit of the doubt
- Talk to the editor
- Check your tone
- Balance your responsibilities and your limits

Nature @nature.com · Jul 18

Agony aunt 🖋️ A cancer researcher is suspicious about a paper they’ve been asked to review. What steps should they take?

go.nature.com/3UhImt0

Should I tell anyone that I suspect misconduct in a paper I’m reviewing?

A cancer researcher is suspicious about a paper they’ve been asked to review. What steps should they take?

go.nature.com

1 3 6

Pradeep Natarajan @pnatarajanmd.bsky.social · Jul 16

Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social

1 3 10

Pradeep Natarajan @pnatarajanmd.bsky.social · Jul 14

An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...

1 4 5

Reposted by Pradeep Natarajan

Romit Bhattacharya @romitb.bsky.social · Jul 3

Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!

Are genetic and contemporary risk factors as powerful as traditional RFs?

#CardioSky #cvPrev

Pradeep Natarajan @pnatarajanmd.bsky.social · Jul 3

Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...

1 3 7

Pradeep Natarajan @pnatarajanmd.bsky.social · Jul 3

Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...

2 12

Reposted by Pradeep Natarajan

The Polygenic Score Catalog @pgscatalog.bsky.social · Jun 17

Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!

2 3

Pradeep Natarajan @pnatarajanmd.bsky.social · May 27

Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social

3 5

Pradeep Natarajan @pnatarajanmd.bsky.social · May 21

Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio

4 8

Reposted by Pradeep Natarajan

Mike Inouye @mikeinouye.bsky.social · May 12

📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...

Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms

tl;dr 👉 There's little/no evidence for this

13 24

Pradeep Natarajan @pnatarajanmd.bsky.social · May 12

Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.

1 4

Pradeep Natarajan @pnatarajanmd.bsky.social · May 7

Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025

1 4 10

Pradeep Natarajan @pnatarajanmd.bsky.social · May 7

A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...

1 11

Pradeep Natarajan @pnatarajanmd.bsky.social · May 6

The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience!
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social

MPG Primer: A Practical Primer on Bayesian Statistics (2025)

YouTube video by Broad Institute

youtube.com

17 39

Pradeep Natarajan @pnatarajanmd.bsky.social · May 5

End of an era icelandmonitor.mbl.is/news/news/20...

Kári Stefánsson steps down as CEO of DeCode Genetics

Kári Stefánsson, founder and long-time CEO of DeCode Genetics, has officially stepped down from his leadership role at the company he established nearly three decades ago. The announcement marks the e...

icelandmonitor.mbl.is

2 4

Reposted by Pradeep Natarajan

James 🎃cello 🌉 @jamespirruccello.com · May 2

Great paper on the intrinsic link between LDL and diabetes risk from @pnatarajanmd.bsky.social @skoyama.bsky.social @somijemmacho.bsky.social and colleagues:

jamanetwork.com/journals/jam...

Genetic Predisposition to LDL-C and Incident Type 2 Diabetes

This cohort study uses whole-exome sequencing, genome-wide genotyping, baseline lipid levels, and incident events to assess the association of genetic predisposition to low-density lipoprotein cholest...

jamanetwork.com

4 11

Reposted by Pradeep Natarajan

Hilary Martin @hilarycmartin.bsky.social · Apr 30

Out today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!

The American Journal of Human Genetics @ajhgnews.bsky.social · Apr 29

📣New from @hilarycmartin.bsky.social & co!
📄Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity

Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity

We leveraged the increased homozygosity in the Genes & Health cohort to perform recessive association testing between 898 diseases and 10,045,406 whole-genome imputed variants, as well as 607,981 whol...

www.cell.com

19 32