Lightnews — Scholar-powered news

Reposted by Cristian Prieto-Garcia

Trends in Genetics @cp-trendsgenetics.bsky.social · Jul 8

"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues

"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."

Read it here:
authors.elsevier.com/sd/article/S...

Figure 2. Overview of N6-methyladenosine (m6A) decay pathways. m6A acts as a destabilizing mark on mRNA.

13 25

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Jun 24

Thank you! 😄

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Jun 24

Thanks a lot! 😃

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Jun 20

Very happy to share some exciting news! I have been awarded a Ramón y Cajal Fellowship 2024 #ryc2024 in the area of Biomedicine, having ranked 4th out of 262 applications with a final score of 99.4 out of 100.

a man wearing a sweater with a horse on it stands in front of a door with a wreath on it

ALT: a man wearing a sweater with a horse on it stands in front of a door with a wreath on it

media.tenor.com

2 1 21

Reposted by Cristian Prieto-Garcia

IBiS - Instituto de Biomedicina de Sevilla @ibis-investigacion.bsky.social · Apr 9

🟠 SCIENCE |

Extra Seminar: "Targeting proteotoxic RNA splicing for therapeutic intervention"

👤: Cristian Prieto-García
🗓️: 11-04-2025 | 12:00 h.
📍: IBiS Assembly Hall

+ INFO ➡️ www.ibis-sevilla.es/es/eventos/2...

@csic.es @goetheuni.bsky.social @unisevilla.bsky.social

2 2

Reposted by Cristian Prieto-Garcia

IBC2 @ibc2-gu.bsky.social · Mar 26

🤩 2nd day of #FCQC2025 conference in Frankfurt was filled with inspiring lectures, vibrant discussions, great posters and a lot of joy of meeting colleagues from all over the world! A huge thanks to all organizers & supporters!
@goetheuni.bsky.social @sfb1177.bsky.social @proxidrugs.bsky.social

4 14

Reposted by Cristian Prieto-Garcia

Kurianlab @kurianlab.bsky.social · Mar 24

RNA Salon in mRNA Translation

We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)

Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social

3 10 15

Reposted by Cristian Prieto-Garcia

jalguerrero.bsky.social @jalguerrero.bsky.social · Mar 7

Retinosis pigmentosas en clínica e investigación! www.rtve.es/play/audios/...

Desde los genes hasta la Retinitis pigmentosa

El ADN genera ARN. En su viaje a los ribosomas, el ARN debe ser procesado mediante \"corte y empalme\" donde se eliminan algunas secciones del ARN y otras se e...

www.rtve.es

2 4

Reposted by Cristian Prieto-Garcia

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Nov 15

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP
doi.org/10.1126/scie...

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

doi.org

5 41 260

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Jan 25

Really thanks for your comment! I just sent you by private message! If you have any question, just let know 😃

1

Reposted by Cristian Prieto-Garcia

Marco A Calzado @marcoacalzado.bsky.social · Jan 23

Today, we had the privilege of having @prieto-garcia.bsky.social at @IMIBIC talking about splicing, USP38, and proteostasis. A magnificent talk and excellent work! 🧬🧪🧫

1 3

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Jan 23

I am happy you enjoy it! Thanks a lot 😃. It was great to visit IMIBIC!

1

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Jan 23

It was great to share Science with people at the
IMIBIC! Great place 🙂. Really thanks to Manuel D. Gahete for the invitation and thanks to @marcoacalzado.bsky.social , Raul , @betsaidaop.bsky.social and others for nice time and plenty Scientific discussions.

Justo P. Castaño 🔬🧬🧫 #SinCienciaNoHayFuturo @justocastano.bsky.social · Jan 23

Enjoying the Seminar by @prieto-garcia.bsky.social at the IMIBIC on Proteotoxic Cryptic Splicing in Diseases: the pathologically relevant interplay between #splicing, #proteostasis #ER-Phagy

2 5

Reposted by Cristian Prieto-Garcia

Martin Schwalm @martinschwalm.bsky.social · Jan 4

Interested in #TPD? This might be for you. What concentrations of UPS inhibitors are safe to use to prove your proteasome dependent degradation mechanism?

#PROTAC #TPD #degradation #Science #drugdiscovery

pubs.acs.org/doi/10.1021/...

Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation

Small molecule degraders such as PROteolysis TArgeting Chimeras (PROTACs) and molecular glues are new modalities for drug development and important tools for target validation. When appropriately opti...

pubs.acs.org

1 8 21

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Dec 16

😂👍

1

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Dec 8

Muchas gracias @fdescubre.bsky.social y @canalsurradio.bsky.social / @canalsurnoticias.bsky.social por permitirme compartir un poquito de ciencia con Andalucia y poder explicar nuestro último Science paper desarrollado en @dikiclab.bsky.social
www.canalsur.es/multimedia.h...

Fundación Descubre con Cristian Prieto

El investigador andaluz Cristian Prieto García publica en la prestigiosa revista 'Science' un artículo sobre una investigación en torno a la retinitis pigmentosa, una afección de la vista de carácter ...

www.canalsur.es

4 16

Reposted by Cristian Prieto-Garcia

Dikic lab @dikiclab.bsky.social · Dec 6

🥁 We are live on BlueSky!! Stay tuned for more news and updates from our lab. We are looking forward to connecting with you here again.
@ibc2-gu.bsky.social @idikic.bsky.social #GoetheUniversity #IBC2

1 6

Reposted by Cristian Prieto-Garcia

Oded Rechavi @odedrechavi.bsky.social · Dec 5

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...

Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance

Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...

www.biorxiv.org

37 160 550

Reposted by Cristian Prieto-Garcia

Watanabe Lab @JHU @watanabelab.bsky.social · Dec 2

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...

We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.

Threads will follow!

20 84 240

Reposted by Cristian Prieto-Garcia

the Node @the-node.bsky.social · Nov 27

"I don’t think I would’ve been better off being a biologist to begin with"

Karen Liu @karenjliu.bsky.social, now a professor in #DevBio, worked in an architectural firm before deciding to pursue a scientific career in her late 20s. Read her interview here:
thenode.biologists.com/i-dont-think...

1 11 29

Reposted by Cristian Prieto-Garcia

mcasas.bsky.social @mcasas.bsky.social · Dec 2

#ciencia #investigación www.diariosur.es/malaga/corre... @prieto-garcia.bsky.social
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

De corretear por la Casa Flores que regentaba su familia a publicar en 'Science' | Diario Sur

Su abuelo fundó ese popular restaurante en el corazón de El Perchel, él investiga en Alemania y obtiene el aval de una de las revistas científicas más prestigiosas

www.diariosur.es

1 3

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Dec 2

Muchas gracias por tus amables palabras 😃

1

Reposted by Cristian Prieto-Garcia

Guillermo López Lluch @glopllu.bsky.social · Nov 15

Más investigación de calidad de científicos españoles intentando entender los mecanismos de reciclado de proteínas y de autofagia y su importancia en la salud. Enhorabuena.

www.science.org/doi/10.1126/...

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

www.science.org

1 2 3

Cristian Prieto-Garcia @prieto-garcia.bsky.social · Nov 28

You can include also @mixmue.bsky.social 😃

Reposted by Cristian Prieto-Garcia

Rune Busk Damgaard @rbdamgaard.bsky.social · Nov 15

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

6 48 49