Christos Proukakis
@proukakis.bsky.social
72 followers 63 following 14 posts
decided to defect from the other one. Professor of neurology and neurogenetics. Science and maybe politics. Strictly personal opinions obviously
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Christos Proukakis @proukakis.bsky.social · Jun 25
activism.bma.org.uk/page/172664/...
Sign the BMA's doctors’ register
Sign our doctors’ register to support our call for a new regulator that understands doctors and protects patients.
activism.bma.org.uk
Christos Proukakis @proukakis.bsky.social · May 9
www.nature.com/articles/s42...

After a long wait, our response to criticism of Gauchian for GBA analysis in Illumina WGS is finally published with @sedlazeck.bsky.social thanks to @asapresearch.parkinsonsroadmap.org
Reply to: Is Gauchian genotyping of GBA1 variants reliable? - Communications Biology
Communications Biology - Reply to: Is Gauchian genotyping of GBA1 variants reliable?
www.nature.com
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Reposted by Christos Proukakis
chtzoulis.bsky.social
Charalampos Tzoulis @chtzoulis.bsky.social · Apr 30
Fresh from our lab - Analyses of muscle biopsies from persons with Parkinson's disease indicate the existence of a subgroup with impaired mitochodrial function. Another step towards biological stratification of PD: www.nature.com/articles/s43...
Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson’s disease - Communications Medicine
Kverneng et al. assess the mitochondrial respiratory chain in skeletal muscle from persons with Parkinson’s disease. Their findings suggest the existence of a subpopulation with complex I deficiency a...
www.nature.com
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Christos Proukakis @proukakis.bsky.social · Mar 13
www.nature.com/articles/d41...
How fast your brain ages is affected by these 64 genes
Scientists also identified anti-ageing drugs and experimental compounds that could target the genes to reverse decline.
www.nature.com
Reposted by Christos Proukakis
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Mar 5
Exciting news! The CRN 2025 Technical Track call for LOIs is OPEN!

This #FundingOpportunity supports novel, sustainable tools to accelerate validation & therapeutic R&D for emerging targets from ASAP discoveries 🧪

Join a global network advancing #ParkinsonsResearch.

Apply now: bit.ly/4bhV96G
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Reposted by Christos Proukakis
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Mar 7
In this #publication, CRN Team Biederer identifies potential risks related to working with α-syn PFFs and outlines best practices for the safe conduct of research with α-syn fibrils, including PPE and decontamination procedures.

🔗 Check out the full publication: shorturl.at/q2sFU
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Reposted by Christos Proukakis
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Feb 20
🧪 We are now accepting LOIs for our Scientific Track funding opportunity through March 20, 2025 (6PM ET).

Your LOI Checklist:
✅ Core Leadership Structure
✅ ECI Requirement
✅ Interdisciplinary Collaboration
✅ Doctoral Degrees
✅ Independent Faculty

Check eligibility & apply: bit.ly/3DXOBxt
A promotional image encouraging applications for Parkinson’s Disease Heterogeneity Funding. The design features bold white text on a blue background, with the words “Scientific Track” highlighted. The Collaborative Research Network (CRN) logo is present, along with an illustration of interlocking puzzle pieces representing different scientific elements
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Christos Proukakis @proukakis.bsky.social · Feb 9
www.nytimes.com/2025/02/07/u...
Trump Administration Cuts Put Medical Progress at Risk, Researchers Say
Grants from the National Institutes of Health come with additional money for overhead. A planned $4 billion cut would leave colleges with large budget gaps.
www.nytimes.com
Christos Proukakis @proukakis.bsky.social · Jan 16
www.thelancet.com/journals/lan...
Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis
Our findings show an exceptionally high mortality rate in the Gaza Strip during the period studied. These results underscore the urgent need for interventions to prevent further loss of life and illum...
www.thelancet.com
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Christos Proukakis @proukakis.bsky.social · Jan 15
www.nature.com/articles/s43...
Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
www.nature.com
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Christos Proukakis @proukakis.bsky.social · Jan 11
Gaza death toll 40% higher than official number, Lancet study finds
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Christos Proukakis @proukakis.bsky.social · Dec 30
Israel built an ‘AI factory’ for war. It unleashed it in Gaza.
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Christos Proukakis @proukakis.bsky.social · Dec 27
www.biorxiv.org/content/10.1...
A personalized multi-platform assessment of somatic mosaicism in the human frontal cortex
Somatic mutations in individual cells lead to genomic mosaicism, contributing to the intricate regulatory landscape of genetic disorders and cancers. To evaluate and refine the detection of somatic mo...
www.biorxiv.org
Christos Proukakis @proukakis.bsky.social · Dec 14
t.co/MVQRa1V8iU?s...
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1 - Nature Structural & Molecular Biology
Here, the authors describe a noncoding genetic variant in GBA1 specific to people of African ancestry that increases the risk of neurodegenerative diseases by interfering with the splicing of mRNA, re...
t.co
Christos Proukakis @proukakis.bsky.social · Dec 14
in todays financial times "how to spend it" supplement
Christos Proukakis @proukakis.bsky.social · Nov 20
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Reposted by Christos Proukakis
sedlazeck.bsky.social
Fritz Sedlazeck @sedlazeck.bsky.social · Nov 19
What mutations hides in our cells? We utilized Nanopore
for WGS single cell sequencing to find out with @proukakis.bsky.social ! Interesting transposon patterns + repeat recombinations! www.medrxiv.org/content/10.1...
Figs: SC deletion also present in bulk. Detection of SC vs. bulk SV
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Christos Proukakis @proukakis.bsky.social · Nov 19
www.medrxiv.org/content/10.1...

posting here too for those that didn't see it in the other place! Long read single cell WGS with @sedlazeck.bsky.social
Single cell long read whole genome sequencing reveals somatic transposon activity in human brain
The advent of single cell DNA sequencing revealed astonishing dynamics of genomic variability, but failed at characterizing smaller to mid size variants that on the germline level have a profound impa...
www.medrxiv.org
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Christos Proukakis @proukakis.bsky.social · Nov 18
cbd.sites.vib.be/en/phdcall2025
Reposted by Christos Proukakis
eleannak.bsky.social
Eleanna @eleannak.bsky.social · Nov 17
Our lab's first preprint! We identified pathways underlying lipid homeostasis and phase separation of alpha-synuclein that dysfunction and carry an increased burden of rare risk variants in Parkinson's disease patients.
www.biorxiv.org/content/10.1...
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease
Alpha-synuclein (αSyn) is an intrinsically disordered protein that accumulates in the brains of patients with Parkinson’s disease and forms intraneuronal inclusions called Lewy Bodies. While the mecha...
www.biorxiv.org
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