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Pseudomonas Genome Database @pseudomonas.com · Jun 6

We have moved Pseudomonas.com back to a Canadian server. Grateful for SFU Research Computing support. Please contact us if you experience any problems.

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Pseudomonas Genome Database @pseudomonas.com · May 30

New review on the ecological and pathogenic versatility of P. aeruginosa:

www.nature.com/articles/s41...

Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility - Nature Reviews Microbiology

Pseudomonas aeruginosa is a functionally versatile bacterium, a leading opportunistic human pathogen and a model organism in microbiology. In this Review, Letizia, Diggle and Whiteley discuss P. aerug...

www.nature.com

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Reposted by Pseudomonas Genome Database

Vaughn Cooper @vscooper.micropopbio.org · Feb 1

I ❤️ pseudomonas.com and its less popular sibling burkholderia.com. If you ever use these tools, take their survey and give them a 🤗

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Pseudomonas Genome Database @pseudomonas.com · Feb 1

Are you a #Pseudomonas researcher? Please take our survey and help shape the direction and priority of future pseudomonas.com database development: forms.gle/gTPT6ruf3mqb...
#microsky #idsky

The Pseudomonas Genome Database - Genome annotation and comparative genome analysis

pseudomonas.com

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Reposted by Pseudomonas Genome Database

ASM @asm.org · Jan 7

A polysaccharide lyase from Stenotrophomonas maltophilia disrupts production of alginate—a dominant component of Pseudomonas aeruginosa biofilms—by P. aeruginosa clinical isolates. The lyase may be useful in infection treatment. Learn more in #AppEnvMicro: journals.asm.org/doi/10.1128/... #MicroSky

Smlt1473 inhibits the mucoid phenotype of P. aeruginosa, but data suggest most effective enzyme concentration varies by isolate. (A) Representative image of phenotypic changes for P. aeruginosa UVA 44618 in the presence and absence of Smlt1473 indicating an inhibitory function. (B–F) Each isolate of P. aeruginosa was grown in the presence and absence of Smlt1473, plate contents were collected, and uronic acid concentration, which corresponds to alginate content, was quantified. Uronic acid concentration was determined by measuring the absorbance at 530 nm (A530) of the resulting solution. High A530 corresponds to high alginate content, whereas low A530 corresponds to low alginate content. Y222F is the catalytically inactive form of Smlt1473 used to show that results are due to an active enzyme. The results are means and standard deviations and statistical analysis was performed using a One-way Welch’s ANOVA and Dunnett’s T3 multiple comparison post-hoc test.

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Reposted by Pseudomonas Genome Database

Tanmay Bharat @tbharat-lab.bsky.social · Dec 16

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors. @mrclmb.bsky.social

journals.plos.org/plospathogen...

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Pseudomonas Genome Database @pseudomonas.com · Dec 5

Different approaches to preparing and sequencing bacterial RNA libraries capture comparable transcriptional profiles:
journals.asm.org/doi/10.1128/...

#microsky #PsWatch #bacteria

RNA-seq reproducibility of Pseudomonas aeruginosa in laboratory models of cystic fibrosis | Microbiology Spectrum

RNA sequencing (RNA-seq) has revolutionized biology, but many steps in RNA-seq workflows can introduce variance, potentially compromising reproducibility. While reproducibility in RNA-seq has been tho...

journals.asm.org

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Reposted by Pseudomonas Genome Database

Patricia Bernal @pbernalt6ss.bsky.social · Nov 30

Great to see you here Alain @fillouxlab.bsky.social. Follow him for all things Pseudomonas aeruginosa, biofilms and T6SS

fillouxlab.bsky.social @fillouxlab.bsky.social · Nov 30

For my first post on BlueSky I thought about to share some of the fun we had at the SCELSE year end party. Many thanks to Allen Chow and all organisers for giving us some relax and enjoyable timer after a very intense 2024.

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Reposted by Pseudomonas Genome Database

Michael Brockhurst @brockhurstlab.bsky.social · Nov 28

2 exciting PhD opportunities:
- with @fionawhelan.bsky.social understanding evolution of transmissibility in Pseudomonas www.findaphd.com/phds/project...
- with @claudiaigler.bsky.social Patrick Cai on AI-powered phage genome design www.findaphd.com/phds/project...

Please spread the word!

[FSE Bicentenary PhD] Generative AI approaches for synthetic phage genome engineering at The University of Manchester on FindAPhD.com

PhD Project - [FSE Bicentenary PhD] Generative AI approaches for synthetic phage genome engineering at The University of Manchester, listed on FindAPhD.com

www.findaphd.com

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Pseudomonas Genome Database @pseudomonas.com · Nov 25

The Pseudomonas Genome Database is now on Bluesky with the Pseudomonas.com web address! We encourage using the #pseudomonas hashtag to note interesting research #pseudomonas #bacteria #microsky #idsky #PsWatch

The Pseudomonas Genome Database - Genome annotation and comparative genome analysis

Pseudomonas.com

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Reposted by Pseudomonas Genome Database

Steve Diggle @digglelab.bsky.social · Nov 16

How to stress out a Pseudomonas aeruginosa quorum sensing researcher #Microsky

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Pseudomonas Genome Database @pseudomonas.com · Nov 25

Las and Rhl quorum-sensing systems have distinct roles in regulating production of the matrix polysaccharide Psl: journals.asm.org/doi/10.1128/...

Quorum sensing regulation of Psl polysaccharide production by Pseudomonas aeruginosa | Journal of Bacteriology

Pseudomonas aeruginosa biofilms are responsible for many treatment-resistant infections in humans. Many cooperative behaviors in P. aeruginosa are controlled by quorum sensing, but evidence for a dire...

journals.asm.org

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Pseudomonas Genome Database @pseudomonas.com · Nov 25

Welcome to our new followers! Looking forward to seeing more of our colleagues here on BlueSky soon.

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Pseudomonas Genome Database @pseudomonas.com · Mar 22

Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection

Biofilm production alters sickness during P. aeruginosa pneumonia by masking the ability of TLR4-TRPV1+ lung nociceptors to activate corticotropin-releasing hormone-mediated acute stress pathways in t...

www.cell.com

Reposted by Pseudomonas Genome Database

Rachel M. Wheatley @rachelmwheatley.bsky.social · Sep 19

Like a keen bean, sharing our latest work on this new app 😎 many many Pseudomonas samples and 4 years later… our paper is out 🎉

TLDR; The diversity of Pseudomonas in ICU patient lungs can accelerate the evolution of antibiotic resistance 🦠

Linking evolutionary biology with clinical outcomes.

Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients - Na...

Here, Caballero et al. provide an in depth characterisation of patients colonized with single or mixed strains of Pseudomonas aeruginosa to demonstrate the impact of within-host diversity on the devel...

www.nature.com

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Pseudomonas Genome Database @pseudomonas.com · Oct 6

Pseudomonas Genome Database version 22.1 has been released. More details at: pseudomonas.com

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