Milo Imbeni
@pyramidalmilo.bsky.social
PhD in Maastricht, microglia and microscopes
Reposted by Milo Imbeni
Bhat et al. Lightweight open-source fine-tuning of SAM2 enables domain-specific microscopy segmentation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 26, 2025 at 3:06 PM
Bhat et al. Lightweight open-source fine-tuning of SAM2 enables domain-specific microscopy segmentation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Milo Imbeni
Uddin et al.
Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans
www.biorxiv.org/content/10.1...
Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans
www.biorxiv.org/content/10.1...
December 26, 2025 at 3:01 PM
Uddin et al.
Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans
www.biorxiv.org/content/10.1...
Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans
www.biorxiv.org/content/10.1...
Reposted by Milo Imbeni
Grandgirard et al NucGen3D: a Synthetic Framework for Large-Scale 3D Nuclear Segmentation with Open-Source Training Data AND Models www.biorxiv.org/content/10.1...
NucGen3D: a Synthetic Framework for Large-Scale 3D Nuclear Segmentation with Open-Source Training Data AND Models
Robust nuclear segmentation in 3D microscopy images is a critical yet unresolved challenge in quantitative cell biology, hindered by the scarcity and variability of annotated volumetric datasets. Beca...
www.biorxiv.org
December 26, 2025 at 3:00 PM
Grandgirard et al NucGen3D: a Synthetic Framework for Large-Scale 3D Nuclear Segmentation with Open-Source Training Data AND Models www.biorxiv.org/content/10.1...
Reposted by Milo Imbeni
The organization of function is mostly determined by anatomical connectivity, but that’s quite different from cytoarchitecture, which is how Brodmann areas are defined.
Connectivity-defined areas probably don't have compact blobby shapes, and are definitely patchy.
Connectivity-defined areas probably don't have compact blobby shapes, and are definitely patchy.
December 23, 2025 at 1:02 PM
The organization of function is mostly determined by anatomical connectivity, but that’s quite different from cytoarchitecture, which is how Brodmann areas are defined.
Connectivity-defined areas probably don't have compact blobby shapes, and are definitely patchy.
Connectivity-defined areas probably don't have compact blobby shapes, and are definitely patchy.
Reposted by Milo Imbeni
Here’s a great paper (one of the precious few) comparing connectivity-based areas to cytoarchitectural areas, from Marie Carlen’s lab. The connectivity maps were the ones that predicted function.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A Prefrontal Cortex Map based on Single Neuron Activity
The intrinsic organization underlying the central cognitive role of the prefrontal cortex (PFC) is poorly understood. The work to date has been dominated by cytoarchitecture as a canvas for studies on...
www.biorxiv.org
December 23, 2025 at 1:02 PM
Here’s a great paper (one of the precious few) comparing connectivity-based areas to cytoarchitectural areas, from Marie Carlen’s lab. The connectivity maps were the ones that predicted function.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Super cute! What kind of substrate do they grow on? Just gelatine? Was thinking about a toy project at home :))
December 22, 2025 at 7:41 PM
Super cute! What kind of substrate do they grow on? Just gelatine? Was thinking about a toy project at home :))