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Reposted by Milo Imbeni

Sara McArdle @saramcardle.bsky.social · 20h

I'm thrilled to share that our work studying microglia morphological changes in early Alzheimer's in mice is up!
www.biorxiv.org/content/10.1...

Unmasking Early Microglial Remodeling in an Alzheimer's Disease Mouse Model

Early neuroimmune remodeling is a critical yet understudied component of Alzheimer's disease (AD) pathogenesis. To investigate microglial contributions to AD development prior to overt plaque depositi...

www.biorxiv.org

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Reposted by Milo Imbeni

Asimov Press @asimovpress.bsky.social · 19h

Our next book: "Making the Modern Laboratory"

An illustrated, coffee table-sized volume, it covers the origins of the machines, organisms and tools used in modern biology research. More importantly, it's a call to imagine the FUTURE of the laboratory.

Come help us write it!

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Reposted by Milo Imbeni

Naomi Alderman @naomialderman.bsky.social · 1d

I cannot understand what these people think the purpose of human life is?

It is *not* "pursue joy, deal justly, love well, try to understand as much and see as much of this beautiful world and of the deepness, richness and variety of human culture and experience as you can before you die"?

Tim Worthington @outonbluesix.bsky.social · 1d

How is this repeatedly made into a policy issue - by *all* parties - when the blunt fact of the matter is that grown adults who are obliged to pay for their own education, and relentlessly pursued to repay their loans, should be able to study whatever the fuck they want.

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Reposted by Milo Imbeni

jofmicroscopy.bsky.social @jofmicroscopy.bsky.social · 10d

"From cells to pixels: A decision tree for designing bioimage analysis pipelines" by Elnaz Fazeli, Robert Haase, Michael Doube, Kota Miura & David Legland is free-to-view here: doi.org/10.1111/jmi....

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Milo Imbeni @pyramidalmilo.bsky.social · 1d

Love it, thanks!

Reposted by Milo Imbeni

Erick Ratamero @erickratamero.com · 1d

My former team at JAX sent two people to SciPy this year and they teamed up to teach a workshop on scaling-up deep learning inference to large-scale bioimage data - it's finally on youtube! if you need an intro to the dask/zarr world, this is a great starting point. www.youtube.com/watch?v=QCWu...

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Reposted by Milo Imbeni

Bookshop.org @bookshop.org · 1d

Can’t decide what to buy on Prime Day?

Try: absolutely nothing, and then go support indie bookstores instead 📚

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Reposted by Milo Imbeni

👻HaunTed👻★ 韓聖安 @knowtheory.net · 1d

Here's a gift link to a very approachable article about what makes Tiktok so sticky. It's a little scold-y, but it touches on what's different about Tiktok that keeps users there better than Reels or Youtube Shorts. All things worth considering when building for the ATmosphere!

wapo.st/4obueib

How TikTok keeps its users scrolling for hours a day

Washington Post reporters analyzed data from over 800 TikTok users to learn how the app turns people into power users, some of whom spend hours per day scrolling.

wapo.st

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Reposted by Milo Imbeni

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 3d

TSPO protein is a pre-cognitive-decline marker in Alzheimer's disease & abundant in plaque-associated microglia

📷 Daniel A. Martinez-Perez et al @fiu.bsky.social
in Acta Neuropathologica @springernature.com

➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social

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Reposted by Milo Imbeni

Reto Fiolka @retof.bsky.social · 2d

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

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Reposted by Milo Imbeni

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 2d

BrAVe: a unified framework for 3D interactive and integrative analysis of cross-modal multi-scale brain atlas data in diverse species https://www.biorxiv.org/content/10.1101/2025.10.04.680445v1

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Reposted by Milo Imbeni

Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 15d

New release of #BigTrace plugin is out. Together with @aafkegros.bsky.social from Simone Köhler group we added a fully automatic tracing mode. + more macro functions and bug fixes github.com/ekatrukha/Bi...

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Reposted by Milo Imbeni

Denis Wirtz @deniswirtz.bsky.social · 5d

Johns Hopkins sophomore student Florin Selaru develops a new scheme to deconvolve colors in histological sections for digital pathology.

It greatly outperforms traditional linear color deconvolution.

Congrats Florin!

Read his paper here: www.biorxiv.org/content/10.1...

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Reposted by Milo Imbeni

Journal of Cell Science @jcellsci.bsky.social · 6d

Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues @cbm-csic-uam.bsky.social @ifimacuam.bsky.social present OSCAR, a framework to quantify 3D stacks with high cellular density.
journals.biologists.com/jcs/article-...

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Reposted by Milo Imbeni

Nicole Rust @nicolecrust.bsky.social · 6d

CW: depression, ideation (& the brain)

Case study: stimulation of the sustantia nigra produces acute, intense depression that dissipates as soon as stimulation stops. Wow.

pubmed.ncbi.nlm.nih.gov/17561432/

(FYI: In follow-up, the individual had no mood issues 5 yrs out; whew!).

Within a couple of seconds, the patient’s face showed an expression of utmost sorrow and he started to sob and cry violently. He repeated over and over again the words ‘‘everything is so dark’’, ‘‘please doctor I don’t want to live.’’ Upon direct questioning, the patient said that he felt very depressed. The stimulation was stopped, and within 10 s, the patient stopped crying and returned to his previous mental status.

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Reposted by Milo Imbeni

Boris Bernhardt @borismontreal.bsky.social · 7d

🚨 New paper in Nature Methods:
HippoMaps: multiscale cartography of the human hippocampus

Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)

Led by @jordandekraker.bsky.social

docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...

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Reposted by Milo Imbeni

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

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Reposted by Milo Imbeni

Cahir O'Kane @cahirokane.bsky.social · 7d

When BCE (before the confocal era) turned into CE (confocal era) - 1987

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 8d

New Online! The advent of confocal laser scanning microscopy in biological research

The advent of confocal laser scanning microscopy in biological research

Nature Reviews Molecular Cell Biology, Published online: 01 October 2025; doi:10.1038/s41580-025-00905-5The advent of laser-scanning confocal microscopy revolutionized cell biology, offering unprecedented resolution and depth and enabling scientists to visualize cellular structures in 3D.

bit.ly

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Reposted by Milo Imbeni

TRIDENT Preclinical Trials @tridentpct.bsky.social · 7d

Follow an exciting new brain imaging platform, @mind-western.bsky.social, partnering group of #TRIDENT. Article about it linked below! 👇🔬👀
www.schulich.uwo.ca/about/news-e...

Researchers launch brain imaging platform with $2.9M boost from Brain Canada - Schulich School of Medicine & Dentistry - Western University

A new high-resolution imaging platform is revealing the brain in extraordinary detail – and sharing the data with scientists worldwide.

www.schulich.uwo.ca

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Reposted by Milo Imbeni

Molecular Neurodegeneration @molneurodegen.bsky.social · 9d

#Microglia networks within the tapestry of #AlzheimersDisease through spatial #transcriptomics

Yi Zhou & Christopher K. Glass @ucsandiego.bsky.social

molecularneurodegeneration.biomedcentral.com/articles/10....

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Reposted by Milo Imbeni

Faculti @faculti.bsky.social · 8d

Could targeting “exhausted” microglia reshape how we treat age- and gene-driven Alzheimer’s disease? Alon Millet , Rockefeller University , discusses: faculti.net/exhausted-mi...
#medicine

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Reposted by Milo Imbeni

Merja Joensuu @joensuulab.bsky.social · 8d

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

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Waggoner Lab @labwaggoner.bsky.social · 12d

Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...

Swapping old immune cells in the brain with fresh ones could treat disease

Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.

nature.com

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Reposted by Milo Imbeni

Alfred Millett-Sikking @amsikking.bsky.social · 10d

The culmination of many years work. One of the most advanced light-sheet microscopes in the world!

-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!

For details see previous posts and here: github.com/amsikking/HT...

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Reposted by Milo Imbeni

Brianna Vandrey @brivandrey.bsky.social · Aug 26

🚨 New preprint! 🚨 Proud to have been a small part of this project

RatDISCO is a simple & affordable tissue-clearing protocol that works in rodent brains and organoids. Enormous potential for imaging long-range projections and labelled neuron populations in the whole brain 🧠

👉 tinyurl.com/670723v1

RatDISCO, a tissue clearing and immunolabelling protocol for large rat brains

RatDISCO is a simple, cost-effective, and reproducible tissue-clearing protocol optimised for immunolabeling in adult rat brains. It enables robust detection of diverse neuronal subtypes, glial popula...

www.biorxiv.org

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