Lightnews — Scholar-powered news

Reposted by Sabrina Sofia Burgener

Nature @nature.com · 18d

Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps

go.nature.com/4pxKgV6

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

go.nature.com

7 15

Sabrina Sofia Burgener @s-burgener.bsky.social · Sep 7

🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ).

A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.

1 2 10

Reposted by Sabrina Sofia Burgener

Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

3 7

Reposted by Sabrina Sofia Burgener

Dr Rebecca Coll @colllab.bsky.social · Sep 2

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

11 18

Reposted by Sabrina Sofia Burgener

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Sep 2

Happening today! In 6.5hrs 🌏

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Aug 18

(1/3) 🚨 We’re back with Edition #2 of our 2025 International Cell Death Seminar Series! 🚨
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️

#ACDS #CellDeath

1 3

Reposted by Sabrina Sofia Burgener

Brett Collins @brettcollins.bsky.social · Sep 2

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

Director, Centre for Chemistry and Drug Discovery

Institute for Molecular Bioscience Join a university ranked in the world’s top 50 Australia’s #1 research institute Based at St Lucia Campus About UQ What started as Queensland's first university in 1...

uq.wd3.myworkdayjobs.com

11 9

Reposted by Sabrina Sofia Burgener

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Aug 28

⏰ Reminder: just 1 week to go until the next International Cell Death Seminar (3 Sept)! Don’t miss this global line-up of speakers 🌍🧬

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Aug 18

(1/3) 🚨 We’re back with Edition #2 of our 2025 International Cell Death Seminar Series! 🚨
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️

#ACDS #CellDeath

2 2

Sabrina Sofia Burgener @s-burgener.bsky.social · Aug 27

Congrats Radek 🥳🤩👏

1 1

Sabrina Sofia Burgener @s-burgener.bsky.social · Aug 18

check out our 2nd International Cell death seminar coming up in two weeks ‼️ @auscelldeathsoc.bsky.social and @ecdoorg.bsky.social

More information👇

Sign up the become an ACDS member - it’s free 🔔

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Aug 18

(1/3) 🚨 We’re back with Edition #2 of our 2025 International Cell Death Seminar Series! 🚨
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️

#ACDS #CellDeath

3

Reposted by Sabrina Sofia Burgener

ECDO European Cell Death Organisation @ecdoorg.bsky.social · Aug 16

🚨 Don’t miss our joint ACSD–ECDO-CDDpress webinar on the exciting science of cell death!

🔬 Featuring top speakers: Grant Dewsonn Caroline Holley, Uris Ros and Alessandro Annibaldi. Cutting-edge talks + inspiring discussions await! ✨

2 4

Reposted by Sabrina Sofia Burgener

Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · Aug 3

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling

Caspases are a family of cysteine proteases conserved across all multicellular life which play critical functions that range from cell death, inflammation and cellular differentiation. Caspases cleave...

www.jbc.org

6 22

Reposted by Sabrina Sofia Burgener

Adam Grant @adamgrant.bsky.social · Aug 2

Friendliness isn't always a sign of trustworthiness. Warmth is easy to fake.

The foundations of trust are reliability and integrity. What counts isn't courtesy in the moment—it's keeping commitments over time.

The best way to inspire confidence is to consistently walk our talk.

4 46 170

Sabrina Sofia Burgener @s-burgener.bsky.social · Aug 1

Congratulations 🎈

1

Reposted by Sabrina Sofia Burgener

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Jul 22

🧬 New paper alert!
Former ACDS committee member Dr Malvina & team identify mitochondrial cardiolipin as a selective inhibitor of CASP4/11-driven cell death & inflammation @inflammasomelab.bsky.social
📄 Read here: www.embopress.org/doi/full/10....

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

www.embopress.org

1 5

Sabrina Sofia Burgener @s-burgener.bsky.social · Jul 17

‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project

www.embopress.org/doi/full/10....

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

www.embopress.org

2 8

Sabrina Sofia Burgener @s-burgener.bsky.social · Jul 9

Big congratulations to Anne!!! so well deserved 👏👏👏👏

1

Sabrina Sofia Burgener @s-burgener.bsky.social · Jul 8

It was a great pleasure having you with us Daniel and thank you for sharing your amazing work on myddosome! ☺️🤩

Daniel Fisch @danielhfisch.bsky.social · Jul 7

Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!

Sign of the University of Queensland, Brisbane

2 5

Sabrina Sofia Burgener @s-burgener.bsky.social · Jun 26

Join us at next week ACDS seminar - lineup of two fantastic speakers 🔊 all infos below 👇

2 1

Reposted by Sabrina Sofia Burgener

Millennium Science @mscience.bsky.social · Jun 17

Register for our upcoming 30 min webinar In the Lab with Dr Sabrina Burgener - Live cell imaging of Inflammasome signalling. us02web.zoom.us/webinar/regi...

@s-burgener.bsky.social
#CellDeath #NLRP3 #Inflammasome #CellAnalysis #InTheLabWebinar

1 2

Sabrina Sofia Burgener @s-burgener.bsky.social · Jun 17

Congratulations Britta, and the whole team! 🥳

Sabrina Sofia Burgener @s-burgener.bsky.social · Jun 14

It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇

Immunity @cp-immunity.bsky.social · Jun 14

Spectosis: Dying for a complement

Red blood cells (RBCs) undergo pathological cell death in hemolytic diseases. In a recent issue of Cell, Chen et al. reveal a mode of programmed cell death, spectosis, in which complement activation initiates (mini)NLRP3-caspase-8 complexes, culminating in hemolysis.

dlvr.it

3 6

Reposted by Sabrina Sofia Burgener

The Lancet Reg Health-Europe @lancetrh-europe.bsky.social · Jun 5

Metabolic dysfunction-associated steatohepatitis (MASH) drives rising morbidity and mortality, yet remains underdiagnosed. A new Health Policy paper by ‪@jvlazarus.bsky.social‬ and colleagues calls for community-based diagnostics: shorturl.at/a0COQ
#LiverSky #SLDthinktank

A call for doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly important contributor to morbidity and mortality. Little emphasis has been placed on its timely diagnosis and interventions t...

shorturl.at

1 3 3

Sabrina Sofia Burgener @s-burgener.bsky.social · Jun 4

Deadline is THIS Friday 🚨 ‼️ 🔔
Still time to apply - don’t miss it
All information below 👇

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · May 29

🚨 Applications for the 2025 ACDS Professional Development Award close soon!
Don't miss your chance to secure $2,000 for travel or training.

🗓️ Deadline: 5pm AEST, Friday 6 June
📩 Apply now: australasiancelldeathsociety.com/acds-awards

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · May 5

(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!

A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.

More info below

1

Sabrina Sofia Burgener @s-burgener.bsky.social · Jun 4

Join us at next month ACDS seminar with two fantastic speakers 🤩

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Jun 3

(1/3) 🔬 Excited to announce our next ACDS Seminar Series is coming up on Wednesday 2 July at 11am AEST! Join us to hear the latest in cell death research from two outstanding speakers. 🧠✨
View the poster for more info:

1 1

Reposted by Sabrina Sofia Burgener

Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · Jun 2

⏳ Time’s ticking! Applications for the 2025 ACDS Professional Development Award are closing soon!

💰 $2,000 available to support your next big step—conference, training, or research visit!
🗓️ Deadline: Friday 6 June, 5pm AEST
🔗 Apply now!

1 1