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Reposted by Daniel Fisch

Avinash Shenoy @avishenoy.bsky.social · 10d

📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...

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Reposted by Daniel Fisch

Jonathan Kagan @jkagan1.bsky.social · 12d

meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection.
www.biorxiv.org/content/10.1...

Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus

Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...

www.biorxiv.org

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Reposted by Daniel Fisch

Jordan Jastrab @jordanjastrab.bsky.social · 12d

Thrilled to share my work from the @jkagan1.bsky.social lab!

TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!

www.biorxiv.org/content/10.1...

#microsky #immunosky

Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus

Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...

www.biorxiv.org

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Reposted by Daniel Fisch

Thiago Carvalho @cyrilpedia.bsky.social · Sep 7

Tools:
"Here, we developed a class of highly sensitive genetically encoded STAT biosensors, termed STATeLights, which allowed direct and continuous detection of STAT activity in live cells with high spatiotemporal resolution."
www.nature.com/articles/s41...

Real-time visualization of STAT activation in live cells using genetically encoded biosensors - Nature Chemical Biology

The signal transducer and activator of transcription (STAT) family proteins are attractive drug targets but tools to monitor their activation are lacking. Now, STAT biosensors have been developed for ...

www.nature.com

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Reposted by Daniel Fisch

Dr Rebecca Coll @colllab.bsky.social · Sep 2

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

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Reposted by Daniel Fisch

Simon Kuestenmacher @simongerman600.bsky.social · Aug 20

Guilty as charged.

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Reposted by Daniel Fisch

Ivan Zanoni @lozanzi.bsky.social · Aug 21

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

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Reposted by Daniel Fisch

Adam Braithwaite @braithwaiteat.bsky.social · Jul 3

Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...

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Reposted by Daniel Fisch

Waggoner Lab @labwaggoner.bsky.social · Aug 12

Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunity @jclinical-invest.bsky.social
www.jci.org/articles/vie...

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Reposted by Daniel Fisch

Jonathan Kagan @jkagan1.bsky.social · Jul 30

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...

Oxidized phospholipid damage signals as modulators of immunity | Open Biology

Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, ...

royalsocietypublishing.org

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Reposted by Daniel Fisch

Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · Jul 27

Zotero has changed my life for the better. What a marvelous piece of software.

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Reposted by Daniel Fisch

Jonathan Kagan @jkagan1.bsky.social · Jul 26

MyD88 cell biology explored in yeast. The fantastic @VictorJCid
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...

MyD88 polymerization and association to cellular membranes in a yeast heterologous model - Cellular and Molecular Life Sciences

MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular patterns (PAMPs). Structurally, MyD88 consists...

link.springer.com

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Daniel Fisch @danielhfisch.bsky.social · Jul 11

Fantastic three days of science at #HFSPmtg25! Thank you @hfspo.bsky.social for hosting us in Melbourne!

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Reposted by Daniel Fisch

Ricardo Henriques @henriqueslab.bsky.social · Jul 10

🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)

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Daniel Fisch @danielhfisch.bsky.social · Jul 7

Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!

Sign of the University of Queensland, Brisbane

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Daniel Fisch @danielhfisch.bsky.social · Jun 30

Thank you @embo.org for a fantastic Fellows’ Meeting 2025. So much amazing science and brilliant young scientists gathered in one place really gives back hope for the future of biomedical research! 🔬🧪

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Daniel Fisch @danielhfisch.bsky.social · Jun 28

Congratulations!!!

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Daniel Fisch @danielhfisch.bsky.social · Jun 24

A huge thank you to @cibss.bsky.social and @uni-freiburg.de for hosting me today on my visit back to where my science journey started! What a fun day filled with great scientific discussions 😁

CIBSS – Centre for Integrative Biological Signalling Studies @cibss.bsky.social · Jun 18

Save the date for next week's #CIBSS seminar with Dr. Daniel Fisch (@danielhfisch.bsky.social) from the @bostonchildrens.bsky.social on "Microbial Sensing in Innate Immunity"!

📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream

More info: kurzlinks.de/y41k

Sharepic with date, time, title of Dr. Daniel Fisch's CIBSS seminar on "Microbial Sensing in Innate Immunity", Tue, June 24, 2025 , 12:00–13:00
at the Inst. of Biology I, Hauptstr. 1 + livestream

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Reposted by Daniel Fisch

CIBSS – Centre for Integrative Biological Signalling Studies @cibss.bsky.social · Jun 18

Save the date for next week's #CIBSS seminar with Dr. Daniel Fisch (@danielhfisch.bsky.social) from the @bostonchildrens.bsky.social on "Microbial Sensing in Innate Immunity"!

📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream

More info: kurzlinks.de/y41k

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Daniel Fisch @danielhfisch.bsky.social · Apr 14

Fantastic work by the Coers lab! GVIN1 (finally) joins the club of antimicrobial GTPases.

David Tobin @tobinlab.bsky.social · Apr 14

Exciting work from neighbor Jörn Coers at Duke identifying a new class of host defense GTPases. Out of a genetic screen they identify the human Giant GTPase GVIN1 (previously annotated as a human pseudogene) in coatomer-based restriction of Burkholderia motility. 1808 aas long!

Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis

Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activated by the cytokine interferon-ga...

www.biorxiv.org

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Reposted by Daniel Fisch

Eva Frickel @frickellab.bsky.social · Apr 13

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

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Reposted by Daniel Fisch

Jonathan Kagan @jkagan1.bsky.social · Mar 8

We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons.
www.science.org/doi/10.1126/...

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules

A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.

www.science.org

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Reposted by Daniel Fisch

Celtic Karla @celtickarla.bsky.social · Mar 1

Want to work in another country?

The HFSP postdoc fellowship supports proposals for frontier, potentially transformative research in the life sciences and cross-disciplinary. high-risk projects are encouraged
LOI opens March 13, 2025

#neuroskyence #academicsky 🧪🧠🪰🌱🧬
www.hfsp.org/funding/hfsp...

Postdoctoral Fellowships | Human Frontier Science Program

www.hfsp.org

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Daniel Fisch @danielhfisch.bsky.social · Dec 14

Could not think of a better way to complete my "X"-odus and finally move here than by sharing this fantastic piece of cell biology! Still blown away by the beautiful imaging and I am glad that I could contribute a small part :)

Inflammasome Lab @inflammasomelab.bsky.social · Dec 9

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

rdcu.be

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Reposted by Daniel Fisch

Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 16

Immunologists (especially if interested in NK cells) should follow @labwaggoner.bsky.social, on twitter the best way to not miss papers 😅 stephen you should ask @rodrahimi.bsky.social to be added to an “immunology starter pack”

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