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Sophia Davidson @sciencesophie.bsky.social · 2d

Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...

So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!

#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience

@nhmrc.bsky.social

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Nature @nature.com · 18d

Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps

go.nature.com/4pxKgV6

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

go.nature.com

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Journal of Experimental Medicine @jem.org · 29d

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...

#Inflammasome #Inflammation

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Sabrina Sofia Burgener @s-burgener.bsky.social · Sep 7

🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ).

A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.

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Brett Collins @brettcollins.bsky.social · Sep 3

🧵In collaboration with Caroline Puente-Lelievre, Ed Moody, Rosie Cater, and Tom Williams we just submitted a new paper describing the prokaryotic origins of the COMMD protein family. @cpuentelelievre.bsky.social‬, ‪@rosemaryjcater.bsky.social‬. @kmichie.bsky.social‬. 1/n

The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking

The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domai...

www.biorxiv.org

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Dr Rebecca Coll @colllab.bsky.social · Sep 2

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

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Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

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Inflammasome Lab @inflammasomelab.bsky.social · Aug 28

Thank you EMBO! I did this course several years ago and it was amazing!

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Reposted by Inflammasome Lab

Malvina Pizzuto @malvinapiz.bsky.social · Jul 23

🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

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Inflammasome Lab @inflammasomelab.bsky.social · Jul 22

Yes! Read our paper to find out how!

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Inflammasome Lab @inflammasomelab.bsky.social · Jul 20

We didn’t do that experiment exactly but did do something similar - we showed that when we trigger noncanonical inflammasome signalling with endogenous effectors in HBECs, this induces filopodial assembly.

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Broz Lab @brozlab.bsky.social · Jul 19

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!

www.embopress.org/doi/full/10....

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

www.embopress.org

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Sabrina Sofia Burgener @s-burgener.bsky.social · Jul 17

‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project

www.embopress.org/doi/full/10....

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

www.embopress.org

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Reposted by Inflammasome Lab

John Dwyer @john-m-dwyer.bsky.social · Jul 15

A joy of the job is sharing moments like this after years of working together. May I present Dr Julian Radford-Smith @jradford-smith.bsky.social, with special guests Barbara and Rosalind. Photos taken by the wonderful @lilydun.bsky.social

Two blokes dressed in gowns and ceremonial hats with two miniature schnauzers in front of the Goddard building at the University of Queensland, St Lucia campus.

Two blokes dressed in gowns and ceremonial hats being dragged towards a bush by two miniature schnauzers in front of the Goddard building at the University of Queensland, St Lucia campus.

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Daniel Fisch @danielhfisch.bsky.social · Jul 7

Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!

Sign of the University of Queensland, Brisbane

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Sabrina Sofia Burgener @s-burgener.bsky.social · Jun 26

Join us at next week ACDS seminar - lineup of two fantastic speakers 🔊 all infos below 👇

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Sabrina Sofia Burgener @s-burgener.bsky.social · Jun 14

It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇

Immunity @cp-immunity.bsky.social · Jun 14

Spectosis: Dying for a complement

Red blood cells (RBCs) undergo pathological cell death in hemolytic diseases. In a recent issue of Cell, Chen et al. reveal a mode of programmed cell death, spectosis, in which complement activation initiates (mini)NLRP3-caspase-8 complexes, culminating in hemolysis.

dlvr.it

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Eric Topol @erictopol.bsky.social · May 29

In @science.org today my essay on predicting and preventing Alzheimer's disease (open-access)

www.science.org/doi/10.1126/...

Predicting and preventing Alzheimer’s disease

With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer’s...

www.science.org

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Hunter Meeting Australia @huntermeetingoz.bsky.social · May 19

The Hunter Meeting has made it to the blue place! 🔵 If you are joining us in the beautiful #HunterValley 2-5 June 2025 - please tag us or search #HunterMeetingOz to follow along. #STEM #CellBiology #DevBio #SpatialOmics @anzscdb.bsky.social #AustralianMeeting

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Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · May 5

(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!

A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.

More info below

#celldeathresearch #careerdevelopment | Australasian Cell Death Society (ACDS)

🥇2025 ACDS Professional Development Award 🥇 Applications are now open! Are you a PhD student or early-career researcher in the cell death field? Don’t miss your chance to apply for our $2,000 travel ...

www.linkedin.com

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Inflammasome Lab @inflammasomelab.bsky.social · May 3

Just make sure you eat ‘em properly. Don’t do a Bill Shorten (zing!) 😂

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Inflammasome Lab @inflammasomelab.bsky.social · May 1

This allowed us to ask cool new questions (🧵3/3):
-are inflammasomes activated & deactivated in the steady-state?
-is inflammasome silencing critical to prevent disease?
-after a major organ challenge, is it critical to silence inflammasomes to restore homeostasis?
👀 our pre-print for the answers!

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Inflammasome Lab @inflammasomelab.bsky.social · May 1

We previously discovered that an unusual mechanism of feedback inhibition turns off #inflammasomes in cells (2018 J Exp Med; shorturl.at/hlFQS). Our new mouse model confirms this also terminates #inflammasomes in vivo (🧵2/3)
shorturl.at/HxS9a

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity | Journal of Experimental Medicine | Rockefeller University Press

The inflammasome generates caspase-1 p20/p10, presumed to be the active protease. Boucher et al. demonstrate that the inflammasome contains an active caspa

shorturl.at

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Inflammasome Lab @inflammasomelab.bsky.social · May 1

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

shorturl.at

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Inflammasome Lab @inflammasomelab.bsky.social · Apr 28

Congratulations @v-hornung.bsky.social! Richly deserved. Wonderful to see another inflammasome great amongst the awardees!

Louis-Jeantet Foundation @louisjeantetfdn.bsky.social · Apr 17

The full videos are available! Check them out: VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social

youtu.be/YBVArSDgFMA

Veit Hornung, winner of the 2025 Collen Jeantet Prize for Translational Medicine

YouTube video by Fondation Louis-Jeantet

youtu.be

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