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SattelyLab

@sattelylab.bsky.social

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SattelyLab @sattelylab.bsky.social · Sep 2

Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1

Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis

Plants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...

www.biorxiv.org

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Reposted by SattelyLab

rnett42.bsky.social @rnett42.bsky.social · 23d

Thanks to Dr. Cassandra Quave for hosting me on her Foodie Pharmacology podcast!

We discussed the molecules responsible for the properties of medicinal plants - and how my lab studies the chemistry that plants use to make them. Check it out!

t.co/nEdpoyN8QD

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SattelyLab @sattelylab.bsky.social · Sep 2

Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis

www.biorxiv.org

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SattelyLab @sattelylab.bsky.social · Aug 29

Congrats Guillermo! Fantastic finish to his ChemE REU program participation

SattelyLab @sattelylab.bsky.social · Aug 22

Congrats, Jack, for a successful PhD defense🎉Party, T-shirt exchange, and a self-made Piñata

SattelyLab @sattelylab.bsky.social · Aug 21

Most recent group photos! So many celebrations🥳

SattelyLab @sattelylab.bsky.social · Aug 7

Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology

Conor McClune @cmcclune.bsky.social · Aug 7

A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale.

Single-gene-per-cell delivery coupled to an effective transcriptional selection system

www.biorxiv.org/content/10.1...

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SattelyLab @sattelylab.bsky.social · Aug 7

@cmcclune.bsky.social will be at the GRC for Single-Cell Approaches in Plant Biology! Be on the lookout for his talk on Wednesday (8/13) at 9.10 am. Talk will be about some new approaches and discoveries recently published in Nature! www.nature.com/articles/s41... #grc #singlecell #plantbiology

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

www.nature.com

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SattelyLab @sattelylab.bsky.social · Aug 7

Watch out for @taralowensohn.bsky.social at the GRC for Single-Cell Approaches in Plant Biology. She will be giving a talk about the pooled gene perturbation and protoplast sorting technologies developed in the lab. Interested? Talk on Monday at 8.10 pm. #grc #singlecell #plants #plantbiology

Reposted by SattelyLab

jamieblum.bsky.social @jamieblum.bsky.social · Jul 23

The Blum lab is recruiting graduate students and postdocs! Grad students: Reach out to me if you're interested in a rotation! Postdoc candidates: recruiting2.ultipro.com/SAL1013SIBS/...

recruiting2.ultipro.com

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SattelyLab @sattelylab.bsky.social · Jul 10

Congrats!

FrankeLab @frankelab.bsky.social · Jul 10

Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.com‬ rdcu.be/evHOF
Fantastic team effort with the Pucker group @bpucker.bsky.social‬ @puckerlab.bsky.social‬ at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis

Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....

rdcu.be

Reposted by SattelyLab

Conor McClune @cmcclune.bsky.social · Jul 2

Pithy coverage by @plantaeofficial.bsky.social of our recent Taxol work

#chemsky #medsky

Plantae.org @plantaeofficial.bsky.social · Jul 2

Plant Science Research Weekly -- Elucidation and recreation of the biosynthetic pathway for taxol (Nature) @cmcclune.bsky.social‬ (Summary by Mary Williams @PlantTeaching.bsky.social)
buff.ly/miccEK3

#PlantaePSRW

Elucidation and recreation of the biosynthetic pathway for taxol | Plantae

Paclitaxel (sold as Taxol) is taxane diterpene natural product of yew trees (Taxus spp.) and a potent stabilizer of microtubules that is effective in treatment of cancers. However…

buff.ly

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Reposted by SattelyLab

Conor McClune @cmcclune.bsky.social · Jun 25

Great article in today’s Stanford Report on our recent work deciphering how yew trees produce Taxol

@sattelylab.bsky.social news.stanford.edu/stories/2025...

New insights in plant gene research could boost cancer drug production

A novel approach to analyzing yew tree genes has revealed key enzymes used to make Taxol, a chemotherapy drug that’s long been difficult and costly to produce.

news.stanford.edu

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SattelyLab @sattelylab.bsky.social · Jun 11

Thanks to @frankelab.bsky.social 🌱

SattelyLab @sattelylab.bsky.social · Jun 11

Fresh off the press! Check out the newest paper from the Sattely lab and @pollyfordyce.bsky.social lab! Spearheaded by @cmcclune.bsky.social #plants #plantbiology #anticancer #drug #taxol

Conor McClune @cmcclune.bsky.social · Jun 11

Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet 🧬🧪🌾

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

www.nature.com

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SattelyLab @sattelylab.bsky.social · Jun 11

Thanks to Jakob Franke for highlighting the Taxol/FoTO1 gene discovery and the mpXsn approach spearheaded by @cmcclune.bsky.social in @nature.com! Check it out here: www.nature.com/articles/d41... #plants #anti-cancer #singlecell #plantbiology

Biochemical breakthrough paves way to reliable supply of anticancer drug

‘Missing’ genes needed for the biosynthesis of a natural anticancer drug have been discovered by perturbing and analysing individual cells of yew trees.

www.nature.com

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SattelyLab @sattelylab.bsky.social · Jun 11

Preprint for the exciting, upcoming Nature paper! @cmcclune.bsky.social, Jack, Chloe, and Ricardo from the Sattely lab (in collaboration with @pollyfordyce.bsky.social) discovered genes for the anti-cancer drug Taxol pathway - plus a gene boosting the production of a bottleneck intermediate!

Conor McClune @cmcclune.bsky.social · Nov 13

Our Taxol pathway preprint!
We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor.
Biggest surprise: a new protein that helps our oxidases produce the correct product

Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors

Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...

www.biorxiv.org

SattelyLab @sattelylab.bsky.social · May 20

Working in science is particularly challenging these days, but hopefully, your plants offer a daily dose of joy. #plants

SattelyLab @sattelylab.bsky.social · Apr 28

Congrats @caseyvchan.bsky.social to a successful Qual exam!!!😀

SattelyLab @sattelylab.bsky.social · Apr 17

The 1st Annual Bay Area Plant Hub recently concluded, and it was a resounding success! We thoroughly enjoyed connecting with everyone. Hope you had a chance to stop by @caseyvchan.bsky.social 's and @taralowensohn.bsky.social 's posters. Plus listen to an intriguing discussion with Beth and others 🌱

Reposted by SattelyLab

Department of Chemistry, Stanford University @stanfordchemistry.bsky.social · Mar 18

🌱 Elizabeth Sattely, Stanford Chemical Engineering professor, explores how plants turn CO2 & sunlight into molecules that boost resilience & human health. Her work aims to create crops resilient to climate change & disease, improving global food systems. #SustainableAgriculture 🌍🍃

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