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Sean Ryder

@seanryderphd.bsky.social

310 followers 410 following 170 posts

RNA biochemist turned CRISPR geneticist. Professor and Vice Chair in Biochemistry and Molecular Biotechnology at UMass Chan Medical School. Proud parent of two wonderful children. Believer in compassion, kindness, mutual respect

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Sean Ryder @seanryderphd.bsky.social · 27d

Amazon Rankings:
#1 New Release in Biotechnology (#3 overall)
#2 New Release in Medical Research (#25 overall)
#3 New Release in Genetics (#10 overall)
I have been assured by the publisher that it will be available in the first week of October.

Thank you all for pre-ordering!
everydayrna.com

Everyday RNA

everydayrna.com

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Reposted by Sean Ryder

Development @dev-journal.bsky.social · 8d

MEX-3’s untranslated region helps worms beat the heat

This Research Highlight showcases the work from Sean Ryder (@seanryderphd.bsky.social) and colleagues:

journals.biologists.com/dev/article/...

Figure 5: Germ layer patterning defects in the mex-3 Δ3′UTR mutant. (A) mex-3 RNAi results in dead embryos with a large expansion of muscle lineage cells (mesoderm, yellow). Control animals develop normally, with all three germ layers present and appropriately patterned. Cytoplasmic (C) green represents GFP::MEX-3 protein, nuclear (N) green indicates endoderm, nuclear (N) yellow indicates mesoderm and nuclear (N) red indicates ectoderm. (B) At elevated temperature, the mex-3 Δ3′UTR mutants form all three germ layers, but patterning appears defective with a moderate expansion of muscle lineage cells (yellow). (C) Fraction of embryos that appear normal versus abnormal binned as in Fig. 4. The genotype and the temperature of growth are shown. CTL is a control for the germ layer background (strain OD1854). All sample sizes and statistical test outcomes are listed in Table S3. Scale bars: 10 μm.

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Reposted by Sean Ryder

Development @dev-journal.bsky.social · 8d

To learn more about this work and the people behind it, we spoke to first author Hannah Brown and corresponding author Sean Ryder @seanryderphd.bsky.social, Professor and Vice Chair for Outreach, Biochemistry and Molecular Biotechnology @umasschan.bsky.social

journals.biologists.com/dev/article/...

Sean Ryder and research group, including first author Hannah Brown. Picture shows seven people with their hands up and/or doing jazz hands in a hallway.

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Sean Ryder @seanryderphd.bsky.social · 12d

Help protect our hard-working federal employees at the NIH

Theresa Kim, PhD, MS @tyk314.net · 12d

The end of FY 2025 is coming, and #OMB appears perfectly content to use us as targets. We are not their chess pieces. We serve our PIs. We are here in our personal capacities. Follow the #NIH.

Sean Ryder @seanryderphd.bsky.social · 18d

I am not ok with this

Alejandra Caraballo @esqueer.net · 19d

Heritage Foundation has released an absolutely insane policy proposal to label all trans people as domestic terrorists. It uses completely made up instances of terrorism and made up statistics but facts don't matter to them.

They want us all eradicated.

Page 1:
Flyer from The Heritage Foundation Oversight Project titled “Transgender Ideology-Inspired Violent Extremism (TIVE): Background and FAQs on Need for an FBI Domestic Terrorism Designation.” The page defines “Transgender Ideology” and “TIVE,” outlining beliefs allegedly associated with them. It claims such ideology justifies violence against opponents or frames opposition as violence. The text references the alleged assassination of Charlie Kirk, urging the FBI to classify TIVE as domestic terrorism.

Page 2:
Continuation of flyer with a section titled “Recent Instances of TIVE-Motivated Acts of Domestic Terrorism.” Lists multiple violent events from 2018 to 2025, attributing them to transgender ideology. Includes mugshots of two alleged attackers. Followed by a “Frequently Asked Questions and Key Terms” section, addressing whether transgender people are terrorists, comparing TIVE with “Nihilistic Violent Extremism,” and discussing FBI designations.

Page 4:
Section titled “Terminology Used by TIVE.” Defines terms including cisgender, deadnaming, Gillick competence, misgendering, “Right to Exist,” “Trans genocide,” and a phrase “You either have a live boy or dead girl, you choose.” Each is presented as terminology used in or associated with TIVE. Page layout is text-heavy, no additional graphics.

Sean Ryder @seanryderphd.bsky.social · 19d

Copies of "Everyday RNA" are arriving in the US. I ordered 30 copies—they arrived at my house yesterday. If you haven't pre-ordered a copy, your best bet is to order directly from World Scientific Press . The online retailers won't get them until later.

www.worldscientific.com/worldscibook...

Everyday RNA

www.worldscientific.com

Sean Ryder @seanryderphd.bsky.social · 27d

Everyday RNA

everydayrna.com

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Sean Ryder @seanryderphd.bsky.social · Sep 4

In 2013, my father lost his life to multiple myeloma. Now, a variety of new treatment options are extending myeloma patient lives for years if not decades. It's been amazing to watch. Support the the NIH, fight back against RFK, and protect academic research.

www.fastcompany.com/91388585/

Why a rare blood cancer has become a testing ground for cancer drug innovation

A model of innovation

www.fastcompany.com

Reposted by Sean Ryder

Sam Wang @samwang.bsky.social · Aug 29

There’s a book from political scientists Macedo and Lee that claims the COVID-19 pandemic was not as much of a threat to public health as was supposed, calling into question the role of expertise.

Here, an excellent corrective to that erroneous position:
joshuasweitz.substack.com/p/revisionis...

Revisionism in the Wake of Covid

A dialogue confronting the premise of revisionist efforts to diminish the pandemic's severity and dismantle public health institutions.

joshuasweitz.substack.com

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Sean Ryder @seanryderphd.bsky.social · Aug 26

Newsweek is reporting the RFK plans an outright ban on mRNA vaccines in the United States within a few months. That's a huge mistake. Please, speak out against those who would derail the most promising technology to curb virus spread since Charles Maitland and cow pox.

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Sean Ryder @seanryderphd.bsky.social · Aug 14

Thanks Aaron! I hope you enjoy it!

Sean Ryder @seanryderphd.bsky.social · Aug 14

I did a thing. I wrote a textbook about #RNA. I wrote it so that those without formal science training could understand what RNA is and how it is used in medicine. It releases in the US and Europe on September 8th. www.worldscientific.com/worldscibook...

A book cover with a strand of RNA on a pink background, with the title, authors name, and publisher.

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Sean Ryder @seanryderphd.bsky.social · Aug 13

Horrible news!

Reposted by Sean Ryder

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · Jul 18

Very timely review for those of you who have been following all of the recent developments in this area... also @cp-trendsbiochem.bsky.social why can't we share via bsky directly from the article???

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Jul 18

📝 Available online - the Feature Review "From transcription to export: mRNA’s winding path to the cytoplasm" from Murray Stewart.

#mRNAProcessing #NuclearExport #RibonucleoproteinComplex

Read it here: authors.elsevier.com/sd/article/S...

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Sean Ryder @seanryderphd.bsky.social · Jul 11

Sounds like another nazi to me.

Sean Ryder @seanryderphd.bsky.social · Jun 26

www.state.gov/releases/off...

To facilitate this vetting, all applicants for F, M, and J nonimmigrant visas will be instructed to adjust the privacy settings on all of their social media profiles to “public.”

I am not ok with this!

Announcement of Expanded Screening and Vetting for Visa Applicants - United States Department of State

The State Department is committed to protecting our nation and our citizens by upholding the highest standards of national security and public safety through our visa process. A U.S. visa is a privil...

www.state.gov

Reposted by Sean Ryder

Brad Lander @bradlander.bsky.social · Jun 17

Hi, it’s Meg again. Brad is still in ICE custody.

We are grateful to the many friends, supporters, and allies who have gathered in Federal Plaza.

Together we are standing up for those with no voice.

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Reposted by Sean Ryder

Brad Lander @bradlander.bsky.social · Jun 17

Hi, this is Meg Barnette, Brad's wife.

While escorting a defendant out of immigration court at 26 Federal Plaza, Brad was taken by masked agents and detained by ICE.

This is still developing, and our team is monitoring the situation closely.

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Sean Ryder @seanryderphd.bsky.social · Jun 15

Grateful to share a microphone and a stage with one of the very best Congresspersons in the nation, @repmcgovern.bsky.social! This was at the #Worcester #NoKings rally. 2000+ energized attendees at the rally behind city hall. #GAIN

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Sean Ryder @seanryderphd.bsky.social · Jun 15

Just get rid of this guy already. I'm sick of his face.

Reposted by Sean Ryder

Greater Assabet Indivisible Network (GAIN) @gain-indivisible.bsky.social · Jun 13

Tomorrow we stand together. We stand for democracy. We stand for basic human decency. We stand so that our great Republic will not fall.

We need you. We need ALL of you. Stand with us. Together we are Indivisible. Together we will have liberty and justice for all

www.facebook.com/share/1AE97P...

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Reposted by Sean Ryder

MeidasTouch @meidastouch.com · Jun 12

Longer video of the forcible removal, detainment, and arrest of Sen. Alex Padilla by the Trump regime during a DHS press conference. Footage provided by Sen. Padilla's team.

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Sean Ryder @seanryderphd.bsky.social · Jun 10

IYKYK

Chad Loder @chadloder.bsky.social · Jun 10

Trump sending 'additional' 2,000 National Guards to Los Angeles, says Pentagon

Charles Minard's 1869 data visualization of Napoleon's Russian campaign. The image has two main parts.
The top part is a flow map on a stylized geographical background. A wide, tan-colored band begins on the left at the Niemen River and moves right towards Moscow, representing the advance of Napoleon's army. The width of the band is proportional to the number of soldiers. As the army advances, the band slightly narrows, and numbers along the path indicate the decreasing army size. From Moscow, a thin black band shows the army's retreat, moving from right to left. This black band narrows dramatically, becoming a tiny sliver by the time it reaches the starting point, visually representing the catastrophic loss of human life.
The bottom part is a line graph connected by vertical lines to the retreat path on the map above. This graph plots the temperature against dates during the retreat. The line shows the temperature consistently dropping far below zero, providing a clear visual explanation for the massive losses shown in the black band.

Sean Ryder @seanryderphd.bsky.social · Jun 9

Yikes!

Reposted by Sean Ryder

DudePool @dudepoolrising.bsky.social · May 28

No kings, masters, overlords or any of that bullshit. Time to take the country back.

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Sean Ryder @seanryderphd.bsky.social · May 29

Anybody else just completely over all of this? Like, for real? I wear this out of the house most places I go so turds know to leave me alone. What up, palanteeeer.