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Sergio Menchero

@sermenchero.bsky.social

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Sergio Menchero @sermenchero.bsky.social · Jul 24

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs

Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...

www.cell.com

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Reposted by Sergio Menchero

Gurdon Institute, University of Cambridge @gurdoninstitute.bsky.social · 8h

It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...

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Sergio Menchero @sermenchero.bsky.social · 6h

Congrats, Alex!! 🍾

Reposted by Sergio Menchero

Margarida Cardoso Moreira @margaridamcm.bsky.social · 1d

Interested in understanding how new cell types evolve? Consider joining our group for a PhD!

The Francis Crick Institute @crick.ac.uk · 1d

2026 PhD recruitment is now open.

As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:

www.crick.ac.uk/careers-stud...

PhD student recruitment

PhD recruitment information.

www.crick.ac.uk

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Reposted by Sergio Menchero

Naomi Moris @nmoris.bsky.social · 2d

Fully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏

www.crick.ac.uk/careers-stud...

Moris Lab | Investigating human trunk development using stem cell-based embryo models

www.crick.ac.uk

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Reposted by Sergio Menchero

Teresa Rayon @trayon.bsky.social · 10d

We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social

🔥 now including in vivo 🐭&👤 embryo data

www.biorxiv.org/content/10.1...

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Reposted by Sergio Menchero

Manuel Irimia @mirimiam.bsky.social · 16d

Last days to apply! Cool project, cool cities! :-)

(Please repost! 🙏)

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

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Sergio Menchero @sermenchero.bsky.social · 19d

Vivan! 🍻

Reposted by Sergio Menchero

The Francis Crick Institute @crick.ac.uk · 21d

NEW PODCAST: ‘A Question of Science’ with Professor Brian Cox.

In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.

Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB

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Reposted by Sergio Menchero

The Francis Crick Institute @crick.ac.uk · 28d

Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code.

www.crick.ac.uk/news/2025-09...

Edith Heard life lessons

Edith Heard, the Crick’s new Director and CEO, shares ten lessons from a life in science, spanning curiosity, courage, coffee, and the secrets of our genetic code.

www.crick.ac.uk

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Reposted by Sergio Menchero

Ollie Inge @oliveringe.bsky.social · 29d

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

www.cell.com

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Sergio Menchero @sermenchero.bsky.social · 29d

Congrats Ollie! Very cool

Reposted by Sergio Menchero

Matt Towers @matt-towers.bsky.social · 29d

I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com

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Reposted by Sergio Menchero

Greg Findlay @gregfindlay.bsky.social · Sep 8

We now have an open post-doc position in the lab:

crick.wd3.myworkdayjobs.com/External/job...

Please apply if you have a background in functional genomics or a related field and are eager to develop methods to map variant effects at scale.

crick.wd3.myworkdayjobs.com

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Sergio Menchero @sermenchero.bsky.social · Sep 4

🍾🍾🍾

Sergio Menchero @sermenchero.bsky.social · Sep 4

Congrats, Bruno!

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Reposted by Sergio Menchero

Jordi Solana @jordisolana.bsky.social · Jun 1

🚨 We’re recruiting PhD students! 🚨

Join the Stem Cell Biology and Evolution lab at @lsiexeter.bsky.social to study planarians, stem cells & evolution.

2 projects available - 1 week left to apply!
Interested and no PhD yet? Apply now. Or help us spread the word! 🙌

www.exeter.ac.uk/research/ins...

LSI PhD programme | Living Systems Institute | University of Exeter

www.exeter.ac.uk

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Sergio Menchero @sermenchero.bsky.social · Sep 4

Huge congratulations!

Reposted by Sergio Menchero

Dirk Benzinger @dbenzinger.bsky.social · Aug 27

Super excited that our latest work is out!

We use optogenetics to dynamically control and study the formation of morphogen gradients.

If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.

James Briscoe @jamesbriscoe.bsky.social · Aug 26

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh

🧵

www.sciencedirect.com/science/arti...

Investigating morphogen and patterning dynamics with optogenetic control of morphogen production

Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

www.sciencedirect.com

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Sergio Menchero @sermenchero.bsky.social · Aug 25

Great news! Congratulations!

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Reposted by Sergio Menchero

Proceedings of the National Academy of Sciences @pnas.org · Aug 21

In #opossums and other #marsupials, #GeneExpression follows familiar rules, but at an unusual pace. In PNAS Journal Club: www.pnas.org/post/journal...

#DevelopmentalBiology #evolution #embryo #transcriptome

The arms and heads of opossums (pictured here one day before birth ) and other marsupials develop faster than their legs and back bodies.
Image credit: Sergio Menchero Fernandez/ Francis Crick Institute, London.

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Sergio Menchero @sermenchero.bsky.social · Aug 21

Nanog beyond pluripotency! Another example of the repurposed role of pluripotency factors after implantation. www.embopress.org/doi/full/10.... and consistent with Miguel Manzanares and Julio Sainz de Aja work on Nanog repressing Pou3f1 journals.biologists.com/bio/article/...

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction | The EMBO Journal

imageimageSOX2 and NANOG are core transcription factors governing pre-implantation pluripotency in the developing embryo. Here, extensive in vivo imaging and genetic analysis uncovers a novel post-imp...

www.embopress.org

Sergio Menchero @sermenchero.bsky.social · Aug 13

Congrats!

Reposted by Sergio Menchero

Ferdinand Marlétaz @ferdix.bsky.social · Aug 13

After nearly twenty years in the making, our attempt at understanding what makes the chaetognath phylum so unique has finally been published! www.nature.com/articles/s41...
with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1

The genomic origin of the unique chaetognath body plan - Nature

Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem ...

www.nature.com

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Sergio Menchero @sermenchero.bsky.social · Aug 12

Amazing news!! Congrats 🍻

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Sergio Menchero @sermenchero.bsky.social · Aug 11

@pnas.org Front Matter posted a nice summary of our recent work on opossum development @crick.ac.uk Thanks Amy McDermott for the highlight, and @amartinezarias.bsky.social for the comments. It says '6 min read', so now might be a good time
www.pnas.org/post/journal...

In opossums, gene expression follows familiar rules but at a strange pace

The arms and heads of opossums (pictured here one day before birth) and other marsupials develop faster than their legs and back bodies. Image credit: Sergio Menchero Fernandez/ Francis Crick Institut...

www.pnas.org

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