shaughp.bsky.social
@shaughp.bsky.social
Reposted
In 2024 I shared a poem in JAMA Onc on giving bad news & the pain of loss when a child dies. It's the worst part of my job.

Cutting research & global aid funding + firing scientists, clinicians, & public health professionals = more children die.

Our leaders have my patients' blood on their hands.
February 17, 2025 at 2:03 AM
Reposted
Axatilimab Displays Durable Responses in cGVHD Irrespective of Number of Prior Lines of Treatment @astct.bsky.social #TANDEM25 #hematology #oncology #GVHD
www.onclive.com/view/axatili...
Axatilimab Displays Durable Responses in cGVHD Irrespective of Number of Prior Lines of Treatment
Axatilimab displayed similar efficacy regardless of the number of prior lines of therapy in chronic graft-versus-host disease.
www.onclive.com
February 14, 2025 at 10:54 PM
Reposted
Reposted
We are still hiring for the Sarah Cannon Transplant and Cellular Therapy Network - pls reach out to me if you are attending #Tandem25
We are hiring to add to our 60+ leukemia/cell therapy/BMT physicians across the Sarah Cannon Transplant and Cellular Therapy Network - pls direct message me to learn more about opportunities for clinical investigators and clinicians 🙏
February 11, 2025 at 4:53 AM
Reposted
How to publish a scientific manuscript in a high-impact journal

Open Access
www.sciencedirect.com/science/arti...
February 11, 2025 at 2:45 PM
Reposted
Coming 🔜 @astct.bsky.social Mobile APP 2.0. New design, new features & enhanced GVHD calculator - trying out the beta version on my way to #Tandem25. Will update once we launch #medsky #bmtsm #CARTcells #geneRx
February 10, 2025 at 9:50 PM
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#tandem25 #bmtsm Arnhold: Ruxolitinib protects from IFNg mediated damage but doesn’t antagonize negative effects of steroids on epithelial regeneration, latter mediated by STAT3 signaling.
February 12, 2025 at 9:10 PM
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#tandem25 #bmtsm Arnhold: IL22 promotes gut epithelial regeneration even in the presence of corticosteroids.
February 12, 2025 at 9:11 PM
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Glad to see @astct.bsky.social @cibmtr.bsky.social making a statement about the value and importance of NIH funding #Tandem25
Ready to kick off @astct.bsky.social @cibmtr.bsky.social #tandem25 with ASTCT President Corey Cutler & CIBMTR scientific co-directors Bronwen Shaw and Jeff Auletta - taking a moment to recognize the importance of NIH support for our work & our NIH colleagues who are unable to join the meeting.
February 12, 2025 at 9:16 PM
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#tandem25 #bmtsm Maas-Bauer: ROCK1 (isoform of ROCK2, target of Belumosudil) is most differentially upregulated kinase in non-responders to aGVHD therapy. ROCK1/2 inhibition reduces aGVHD in mouse model of major MHC mismatch allo. Assoc w reduction of CD11b+ cells in gut.
February 12, 2025 at 9:20 PM
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#tandem25 #bmtsm Maas-Bauer: ROCK1/2 inhibition of monocyte/macrophage and DCs ameliorates aGVHD, but does not (completely) antagonize tumor cell killing (in vitro and in vivo models).
February 12, 2025 at 9:27 PM
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#tandem25 #bmtsm Maas-Bauer: ROCK1/2 inhibition and JAK inhibition have synergistic effects (!). Belumosudil has yet to be studied clinically in SR-aGVHD.
February 12, 2025 at 9:29 PM
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ASTCT 2025 APP Diana Velez and our great nursing staff at Sarah Cannon Methodist San Antonio presenting on late neuro tox in CART
February 12, 2025 at 11:02 PM
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#tandem25 #bmtsm Maas-Bauer: ROCK1/2 inhibition downregulate NFkB signaling assoc with inflammation and upreg of anti-inflammatory IL10 — basically modulating n of monocyte phenotype to antiinflammatory M2 type. Decreased F-actin in ROCK1/2i treated is assoc with deceased monocyte migration.
February 12, 2025 at 9:24 PM
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Are you at #Tandem25? Visit booth 340 to learn more about Sarah Cannon Transplant and Cellular Therapy Network - the largest provider of transplantation and cellular therapy in the US. And yes, we are hiring for several positions including physicians, PharmDs, nurses, and more.
February 13, 2025 at 12:33 AM
ASTCT 2025 APP Diana Velez and our great nursing staff at Sarah Cannon Methodist San Antonio presenting on late neuro tox in CART
February 12, 2025 at 11:02 PM
Reposted
In addition to the potential to impact individual outcomes of those patients we serve, physician leadership is needed now more than ever to address the gaps in our system of healthcare
jama.com JAMA @jama.com · Dec 26
Viewpoint: Medical students and residents need to be educated on health policy issues like insurance, payment models, and drug regulation to better understand the factors that impact patient health outcomes.

https://ja.ma/3BuTE7P
December 27, 2024 at 11:24 AM
Reposted
We are hiring to add to our 60+ leukemia/cell therapy/BMT physicians across the Sarah Cannon Transplant and Cellular Therapy Network - pls direct message me to learn more about opportunities for clinical investigators and clinicians 🙏
December 27, 2024 at 4:26 AM
Reposted
Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results

"All patients had bilateral hearing restoration."

Open Access
www.nature.com/articles/s41...
December 29, 2024 at 2:21 AM
Reposted
4. How to Pick a Graduate Advisor

Thanks💐 @richardhuskey.bsky.social

Open access
www.cell.com/neuron/pdf/S...
December 9, 2024 at 5:24 PM
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Three must read papers for PhD students. #scisky #PhD #science #research #academicsky

1. The importance of stupidity in scientific research

Open Access
journals.biologists.com/jcs/article/...
November 24, 2024 at 1:54 PM
Reposted
A recent study unpicks a key immune-mediated mechanism of mutant IDH–blocking drugs such as vorasidenib in the treatment of IDH-mutant glioma. Learn more in a new Clinical Implications of Basic Research article: nej.md/4f3dIMf

#MedSky
Heating Up IDH-Mutant Gliomas | NEJM
A recent study unpicks a key immune-mediated mechanism of mutant IDH–blocking drugs such as vorasidenib in the treatment of IDH-mutant glioma.
nej.md
December 11, 2024 at 5:09 PM
Reposted
December 10, 2024 at 10:20 PM