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Simon Bayly @simonbayly.bsky.social · 3h

The global population is still increasing. What reason could there be that these people want more babies of their particular race? (rhetorical)

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Simon Bayly @simonbayly.bsky.social · 4h

This isn’t going to end well

Alex Hanna-ween @alexhanna.bsky.social · 19h

I'm not an economist but seems worrying that the whole US economy is seven companies in a trenchcoat, passing the same $20 up and down

Carl Quintanilla @carlquintanilla.bsky.social · 21h

NVIDIA and OpenAi:

Concerns that their “increasingly complex and interconnected web of business transactions is artificially propping up the trillion-dollar AI boom.“

@bloomberg.com $NVDA 👀
www.bloomberg.com/news/feature...

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Simon Bayly @simonbayly.bsky.social · 12h

Morning folks. Should we turn this into a ‘Station F’ for UK life sciences/biotech?

A photo of the building in Kings Cross that was being built for Merck/MSd

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Simon Bayly @simonbayly.bsky.social · 7h

In not particularly surprising news, protein-ligand machine learning models are unreliable becuase they replicate folding patterns not actual physics www.nature.com/articles/s41... #biotech

Investigating whether deep learning models for co-folding learn the physics of protein-ligand interactions - Nature Communications

This study shows that deep-learning-based co-folding models often produce physically unrealistic structures and are unsusceptible in their predictions to significant binding site modifications, demonstrating bias towards training data and underscoring the need for stronger integration of physical principles.

www.nature.com

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Derek Lowe @dereklowe.bsky.social · 8h

I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:

Bright green transparent metal-organic framework crystals prepared with copper and a “multipronged” carboxylic acid ligand. The crystals formed blocky roughly rectangular pieces with some very large emerald-like chunks.

Pink/red transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed as a mixture of long rectangular types and aggregated chunks.

Purple transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed long slightly blocky needles.

Clear transparent metal-organic framework crystals prepared with zirconium and a “multipronged” carboxylic acid ligand. The crystals formed chunky hexagons.

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Simon Bayly @simonbayly.bsky.social · 8h

Very pretty!

Simon Bayly @simonbayly.bsky.social · 9h

MOFs won it. I feel sorry for Fujita who shared the Wolf prize with Yaghi in 2018. #chemsky

Katharine Sanderson @kms163.bsky.social · 10h

the 2025 #Nobel prize in Chemistry for MOFs! Delighted to have dug into the potential of these amazing materials earlier this year www.nature.com/articles/d41...

World’s most porous sponges: intricate carbon-trapping powders hit the market

Metal-organic frameworks were the next big thing in chemistry when they were invented more than three decades ago. Now, these intriguing materials are becoming commercial tools for capturing carbon dioxide and harvesting water from the air.

www.nature.com

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Simon Bayly @simonbayly.bsky.social · 12h

Morning folks. Should we turn this into a ‘Station F’ for UK life sciences/biotech?

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Simon Bayly @simonbayly.bsky.social · 1d

Soufflé Therapeutics may be fantastic for all I know, but from the name it sounds like a lot of hot air #biotech

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Scott Bagley @bagphos.bsky.social · 1d

Calling your reaction “metal-free” just because the metal isn’t d-block is…certainly a choice
#ChemSky

a close up of a man 's face with the word interesting written below him

ALT: a close up of a man 's face with the word interesting written below him

media.tenor.com

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Simon Bayly @simonbayly.bsky.social · 1d

Cell go brrrrrrrrrr!

Manuel Thery @manuelthery.bsky.social · 1d

What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social

rupress.org/jcb/article-...

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James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Bento Lab 🧬 @bento.bio · 1d

Researchers have developed a portable bird flu genomics workflow to track emerging strains in remote locations:

🧬 Bento Lab used to extract viral RNA
🧬 ONT MinION for genome sequencing
🧬 Full workflow on an Antarctic research vessel

🔗 Full story: bento.bio/story/tracki...

Tracking Bird Flu in Antarctica

A research team has successfully sequenced a near-complete bird flu genome aboard a ship in Antarctic waters, proving that portable lab equipment can generate critical information about viral threats…

bento.bio

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Benjamin Pope @benjaminpope.bsky.social · 1d

it's actually not two Nobels for Josephson junctions, just one that tunnelled over a gap of 52 years

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Science|Business @sciencebusiness.net · 1d

EU Council backs exploring a new #LifeSciences investment fund to boost private #R&D, bridge the gap from discovery to deployment, and strengthen Europe’s #healthinnovation.

🔎Read here:

EU Council calls for life sciences investment fund

EU governments want to launch a European Life Sciences Investment Fund, as part of a coordinated strategy to make Europe an attractive place for private investment in research and innovation.

buff.ly

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Simon Bayly @simonbayly.bsky.social · 1d

Cell biology is chaos

Bart Deplancke @bartdeplancke.bsky.social · 2d

🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China

Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics

This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.

www.nature.com

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Uschi Symmons @usymmons.bsky.social · 1d

Really enjoying this story about Fred Ramsdell not knowing about his Nobel prize in Medicine, because he's offline, hiking in Idaho.

There seems to be such pressure to be reachable all the time nowadays, that is nice to see! 😅

www.theguardian.com/science/2025...

Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid

Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable

www.theguardian.com

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womensartbluesky.bsky.social @womensartbluesky.bsky.social · 1d

Elin Thomas, UK textile artist who uses embroidery/crochet to create unique work resembling petri dishes and bacteria spores #womensart

Photo looking down on four petri dishes, neatly arranged, with what resembles bacteria and mould growing inside created with crochet and embroidery

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Esther Schindler @estherschindler.bsky.social · 1d

I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.

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Simon Bayly @simonbayly.bsky.social · 1d

Not surprising as academia is not set up to retain an develop talent. It trains tons of people and then exploits them as they compete for very scarce permanent roles.

Martin Smith @martinrsmith.bsky.social · 1d

“In the recent DSIT survey of the UK Research & Development workforce, only 52 per cent of higher education respondents said the culture of their organisation enabled them to perform their best work, compared to 85 per cent in the private sector.”

Elizabeth Gadd @lizziegadd.bsky.social · 1d

Adding my voice to the chorus battling to retain an increased focus on people, culture, and environment in the next REF... wonkhe.com/blogs/the-ba...

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Simon Bayly @simonbayly.bsky.social · 1d

How does this work if the Broad is winning the patent battle for mammalian CRISPR? #biotech

Thiago Carvalho @cyrilpedia.bsky.social · 1d

'The agreement with Algen Biotechnologies gives AstraZeneca exclusive rights to develop & commercialise therapies fm the gene-editing technology known as Crispr. Algen was spun out of the Berkeley lab where Jennifer Doudna developed the technology, for which she won the Nobel Prize for chemistry'

AstraZeneca signs $555mn AI deal to identify immunology targets

Pharmaceutical company is latest to invest in artificial intelligence to speed drug development

www.ft.com

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dag @davidallengreen.bsky.social · 1d

By embracing Brexit for party advantage, the Conservative and Unionist party both destroyed itself and, in time, dismantled the union.

A political morality tale, a fable of hard folly.

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Simon Bayly @simonbayly.bsky.social · 2d

Not what I predicted, but an important discovery that Brunkow and Ramsdell worked on while at a UK biotech company (Celltech Chiroscience)

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Michael Gilman @gilman.bsky.social · 2d

Love this story about one of today's Nobel winners, Mary Brunkow.

(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)

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Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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