Simon Sch.
@simonrecyclable.bsky.social
🔬PhD research in cell biology on the regulation of mitochondrial DNA copy number in yeast🔍Scientist in R&D💡aims for a peaceful world that is everyones's sanctuary for humanity and nature 🌈🌍 views are my own
Reposted by Simon Sch.
Our new paper is out 🎉 in @narjournal.bsky.social
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast.
Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators!
academic.oup.com/nar/article/...
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast.
Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators!
academic.oup.com/nar/article/...
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Abstract. Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces c
academic.oup.com
January 15, 2026 at 3:40 PM
Our new paper is out 🎉 in @narjournal.bsky.social
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast.
Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators!
academic.oup.com/nar/article/...
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast.
Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators!
academic.oup.com/nar/article/...
Reposted by Simon Sch.
Our study on the molecular function of translational activators for mitochondrial protein synthesis is published:
rdcu.be/eSWxT
A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social
Funded by @kawresearch.bsky.social
rdcu.be/eSWxT
A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social
Funded by @kawresearch.bsky.social
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation
Nature Structural & Molecular Biology - Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy,...
rdcu.be
December 3, 2025 at 1:39 PM
Our study on the molecular function of translational activators for mitochondrial protein synthesis is published:
rdcu.be/eSWxT
A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social
Funded by @kawresearch.bsky.social
rdcu.be/eSWxT
A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social
Funded by @kawresearch.bsky.social
Reposted by Simon Sch.
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
October 14, 2025 at 10:56 AM
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
Reposted by Simon Sch.
Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
October 10, 2025 at 3:55 PM
Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
Reposted by Simon Sch.
🏅We congratulate 🌟Nils Bertram🌟 @lmumuenchen.bsky.social, on winning a FEBS Letters #PosterPrize at the #EMBOFEBSproteostasis meeting, held in Espoo, Finland! 🎉👏👏👏
📸 Photo: Nils with our Managing Editor, Dr. Duncan Wright
📸 Photo: Nils with our Managing Editor, Dr. Duncan Wright
October 9, 2025 at 1:01 PM
🏅We congratulate 🌟Nils Bertram🌟 @lmumuenchen.bsky.social, on winning a FEBS Letters #PosterPrize at the #EMBOFEBSproteostasis meeting, held in Espoo, Finland! 🎉👏👏👏
📸 Photo: Nils with our Managing Editor, Dr. Duncan Wright
📸 Photo: Nils with our Managing Editor, Dr. Duncan Wright
Reposted by Simon Sch.
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:56 PM
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Reposted by Simon Sch.
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:39 PM
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Reposted by Simon Sch.
🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...
www.biorxiv.org
February 16, 2025 at 2:04 PM
🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA
Excited to share our new preprint on Mrx6, who binds the Lon protease Pim1 N-terminal domain through a bipartite motif to confer selective substrate specificity and regulate mtDNA copy number! Looking forward to all your feedback and follow-ups! A huge thank you to everyone who contributed!
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...
www.biorxiv.org
February 16, 2025 at 1:59 PM
Excited to share our new preprint on Mrx6, who binds the Lon protease Pim1 N-terminal domain through a bipartite motif to confer selective substrate specificity and regulate mtDNA copy number! Looking forward to all your feedback and follow-ups! A huge thank you to everyone who contributed!
Reposted by Simon Sch.
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1
February 16, 2025 at 12:32 PM
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1
Reposted by Simon Sch.
Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
February 1, 2025 at 11:41 AM
Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Simon Sch.
Mitochondria (top) and microtubules (bottom) in a cell videoed through a microscope. #Science #Biology #CellBiology #microscopy
January 31, 2025 at 8:32 PM
Mitochondria (top) and microtubules (bottom) in a cell videoed through a microscope. #Science #Biology #CellBiology #microscopy
Reposted by Simon Sch.
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
January 10, 2025 at 6:56 PM
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Reposted by Simon Sch.
NEW: 2024 has just been confirmed as the warmest year on record, and the first to breach the 1.5C threshold.
We used a ridgeline (Joy Division inspired) chart to visualise daily temperature anomalies since 1940.
2024 clearly stands out with 100% of its days above 1.3C and 75% above 1.5C.
We used a ridgeline (Joy Division inspired) chart to visualise daily temperature anomalies since 1940.
2024 clearly stands out with 100% of its days above 1.3C and 75% above 1.5C.
January 10, 2025 at 8:04 AM
NEW: 2024 has just been confirmed as the warmest year on record, and the first to breach the 1.5C threshold.
We used a ridgeline (Joy Division inspired) chart to visualise daily temperature anomalies since 1940.
2024 clearly stands out with 100% of its days above 1.3C and 75% above 1.5C.
We used a ridgeline (Joy Division inspired) chart to visualise daily temperature anomalies since 1940.
2024 clearly stands out with 100% of its days above 1.3C and 75% above 1.5C.
Reposted by Simon Sch.
Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @jcellbiol.bsky.social! A wonderful early present to see this now online!
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Functionally conserved inner mitochondrial membrane proteins CCDC51 and Mdm33 demarcate a subset of fission events | Journal of Cell Biology | Rockefeller University Press
Edington et al. determine that Mdm33 and CCDC51 are functionally conserved mitochondrial inner membrane proteins that are required for normal mitochondrial
rupress.org
December 24, 2024 at 8:07 PM
Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @jcellbiol.bsky.social! A wonderful early present to see this now online!
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Reposted by Simon Sch.
One big advantage of laser induction is you can cause pearling whenever you want, in just the mitochondrial tube that you want, so it is very precise and controllable. Combined with STED imaging it has been possible to get some beautiful images of cristae and nucleoids during pearling
December 23, 2024 at 5:49 PM
One big advantage of laser induction is you can cause pearling whenever you want, in just the mitochondrial tube that you want, so it is very precise and controllable. Combined with STED imaging it has been possible to get some beautiful images of cristae and nucleoids during pearling
Reposted by Simon Sch.
The transient nature of pearling makes it hard to detect - in normal cells you might need to sit and watch one spot for a long time and then, if you blink, you'll miss it
December 23, 2024 at 5:49 PM
The transient nature of pearling makes it hard to detect - in normal cells you might need to sit and watch one spot for a long time and then, if you blink, you'll miss it
Reposted by Simon Sch.
He found that pearling was ubiquitous, occurring in every cell type that he has looked at, including: U2OS, Hek293, COS7, RPE1, Jurkat, primary human fibroblasts primary CD8 T-cells, iPSC derived neurons, and budding yeast (shown here).
December 23, 2024 at 5:49 PM
He found that pearling was ubiquitous, occurring in every cell type that he has looked at, including: U2OS, Hek293, COS7, RPE1, Jurkat, primary human fibroblasts primary CD8 T-cells, iPSC derived neurons, and budding yeast (shown here).
Reposted by Simon Sch.
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Simon Sch.
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
December 23, 2024 at 4:37 PM
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
Reposted by Simon Sch.
Pearling Drives Mitochondrial DNA Nucleoid Distribution https://www.biorxiv.org/content/10.1101/2024.12.21.629917v1
December 22, 2024 at 8:30 PM
Pearling Drives Mitochondrial DNA Nucleoid Distribution https://www.biorxiv.org/content/10.1101/2024.12.21.629917v1
Reposted by Simon Sch.
EXTRA! EXTRA! Read all about it! Latest SGD newsletter! www.yeastgenome.org/blog/sgd-new...
- AlphaFold
- YeastMine
- Community wiki
- SGD’s new GENETICS publication
- New yeast microPublications
- Alliance of Genome Resources 7.4
- Give a Gift/Support SGD
- Upcoming conferences
- Happy Holidays!
- AlphaFold
- YeastMine
- Community wiki
- SGD’s new GENETICS publication
- New yeast microPublications
- Alliance of Genome Resources 7.4
- Give a Gift/Support SGD
- Upcoming conferences
- Happy Holidays!
December 13, 2024 at 6:30 PM
EXTRA! EXTRA! Read all about it! Latest SGD newsletter! www.yeastgenome.org/blog/sgd-new...
- AlphaFold
- YeastMine
- Community wiki
- SGD’s new GENETICS publication
- New yeast microPublications
- Alliance of Genome Resources 7.4
- Give a Gift/Support SGD
- Upcoming conferences
- Happy Holidays!
- AlphaFold
- YeastMine
- Community wiki
- SGD’s new GENETICS publication
- New yeast microPublications
- Alliance of Genome Resources 7.4
- Give a Gift/Support SGD
- Upcoming conferences
- Happy Holidays!
Reposted by Simon Sch.
Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 21, 2024 at 8:26 PM
Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Simon Sch.
Membrane blebs forming from the plasma membrane of a cell videoed through a microscope. If the bleb gets big enough, mitochondria, enter and explore. The cell is at the bottom where many mitochondria (bright signal) surround the nucleus (lack of signal). #Science #Biology #CellBiology #microscopy
December 21, 2024 at 11:22 PM
Membrane blebs forming from the plasma membrane of a cell videoed through a microscope. If the bleb gets big enough, mitochondria, enter and explore. The cell is at the bottom where many mitochondria (bright signal) surround the nucleus (lack of signal). #Science #Biology #CellBiology #microscopy