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Smolka Lab @smolka-lab.bsky.social · 20d

A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social
and Michelle Wang

brookscrickard1.bsky.social @brookscrickard1.bsky.social · 21d

Just throwing this out there as a significant conceptual advance in the field

www.biorxiv.org/content/10.1...

The Eukaryotic homology search complex distorts donor DNA structure to probe for homology

Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair proc...

www.biorxiv.org

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Reposted by Smolka Lab

Mateusz Wagner @mateuszwagner.bsky.social · Jun 13

Honored to receive an Outstanding Poster Award at the Protein Science Symposium! Huge thanks to the @weillinstitute.bsky.social and @weillcornell.bsky.social for an amazing event—and of course, big shoutout to the @smolka-lab.bsky.social for making the poster results possible!

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Reposted by Smolka Lab

Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · May 22

We are counting down the days to our Protein Science Symposium on June 10-12! Thrilled to be hosting our colleagues from WCM @weillcornell.bsky.social as well as keynote speakers Dr. Christopher Lima @christopherdlima.bsky.social and Dr. ‪Jin Zhang @jinzhanglab.bsky.social

3D rendering of a Ankyrin R adaptor protein

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Smolka Lab @smolka-lab.bsky.social · May 16

New preprint from the lab:

ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM.

Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar.

www.biorxiv.org/content/10.1...

An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks

In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synt...

www.biorxiv.org

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Smolka Lab @smolka-lab.bsky.social · May 11

Double award to the fantastic graduate student @mateuszwagner.bsky.social …

Mateusz Wagner @mateuszwagner.bsky.social · May 11

I'm honored to have received the George P. Hess Award from the MBG department and the Outstanding Graduate Teaching Award from CALS. These recognitions wouldn't have been possible without the support of the incredible @smolka-lab.bsky.social and the exceptional students of BIOMG3320.

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Reposted by Smolka Lab

Marjolein van der Meulen @mchvdm.bsky.social · May 8

Devasting that clinical trial for Jim's PediaFlow baby heart pump is on hold due the stop on all DOD funding at Cornell.

Funded by DOD CDMRP, Congressionally Directed Medical Research Programs, yet White House stopped Congress funds

#ResearchSavesLives #Standup4Science
youtu.be/a7aUBvBcPV4

Research at Risk: Life-saving heart pumps for babies

YouTube video by Cornell University

youtu.be

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Reposted by Smolka Lab

Humberto Basilio @humbertobasilio.bsky.social · Mar 10

🚨🧪 Are you a researcher affected by the recent cancellation of federal grants and contracts at Columbia University?

I'm working on a story for @Nature.com. If you want to chat, your identity will be kept private.

Signal: humbertobasilio.24
Email: [email protected]

Repost please!

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Reposted by Smolka Lab

Joe Peters Lab @joepeterslab.bsky.social · Mar 6

Our preprint is now published www.science.org/doi/10.1126/...

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Reposted by Smolka Lab

Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · Mar 4

Applications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology should apply by April 14, 2025. Please repost! wicmb.cornell.edu/emerging-sch...

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Smolka Lab @smolka-lab.bsky.social · Feb 19

Senior graduate students and postdocs, here is a great opportunity to network, showcase your science and get to know Cornell and beautiful Ithaca! Please repost.

Jeremy Baskin @jeremybaskin.bsky.social · Feb 19

Some good news: applications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology at Cornell should apply by Apr 14. Please repost! wicmb.cornell.edu/emerging-sch...

Flyer for Weill Institute Emerging Scholars Symposium at Cornell University, with QR code at bottom to obtain more information

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Reposted by Smolka Lab

Will Comstock, PhD @wjcomstock.bsky.social · Feb 13

My first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out:
doi.org/10.1016/j.jb...

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Smolka Lab @smolka-lab.bsky.social · Feb 13

Congrats, that is a big deal!

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Smolka Lab @smolka-lab.bsky.social · Feb 11

Very interesting work by the @zhalab.bsky.social showing why Ku is essential in human cells

Zha Lab @zhalab.bsky.social · Feb 10

Exciting results! Using AID-Degron system, Dr. Yimeng Zhu in the lab found that Ku suppresses RNA-mediated innate immunity to accommodate Alu-expansion in primates - solving the misery of Ku essentiality in human cell and uncover 94r^2 for co evolution www.biorxiv.org/content/10.1...

Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion

Ku70 and Ku80 form Ku, a ring-shaped protein that initiates the non-homologous end-joining (NHEJ) DNA repair pathway.[1][1] Specifically, Ku binds to double-stranded DNA (dsDNA) ends and recruits othe...

www.biorxiv.org

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Smolka Lab @smolka-lab.bsky.social · Feb 10

Who did you contact? Please forward me the contact info, thanks!

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Smolka Lab @smolka-lab.bsky.social · Jan 21

Great work by graduate students Will Comstock (@wjcomstock.bsky.social) and Shrijan Bhattarai (@rainshj.bsky.social)

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Smolka Lab @smolka-lab.bsky.social · Jan 21

In this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q!

Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization.

A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.

Profiling Tel1 Signaling Reveals a Non-Canonical Motif Targeting DNA Repair and Telomere Control Machineries

The stability of the genome relies on Phosphatidyl Inositol 3-Kinase-related Kinases (PIKKs) that sense DNA damage and trigger elaborate downstream si…

www.sciencedirect.com

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Reposted by Smolka Lab

ZhaoLab @zhaolabski.bsky.social · Jan 4

Happy to share a new work from the lab on how DNA damage checkpoint can be down-regulated. rdcu.be/d5o3E. Congrats to all authors at @mskcancercenter.bsky.social and our Weill BCMB student @tzippora.bsky.social. gradschool.weill.cornell.edu/bcmb-allied-...

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Smolka Lab @smolka-lab.bsky.social · Dec 17

Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS.

ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications.

We applied it to DDR kinases. Please share.

www.biorxiv.org/content/10.1...

We developed a proteomic kinase activity sensor platform (ProKAS) for the analysis of kinase signaling using mass spectrometry. ProKAS is based on a tandem array of peptide sensors with amino acid barcodes that allow multiplexed analysis for spatial, kinetic, and screening applications.

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Smolka Lab @smolka-lab.bsky.social · Nov 21

Please add us

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Reposted by Smolka Lab

Jeremy Baskin @jeremybaskin.bsky.social · Nov 21

Great “tools of the trade” piece by Xiaofu Cao in Nat Rev Mol Cell Biol about her recent paper exploiting cell cycle-dependent phosphorylation to make a conditional protein relocalization tool!

ToT piece: rdcu.be/d0Utp
Original paper (@naturecellbiology.bsky.social): www.nature.com/articles/s41...

Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment

Nature Reviews Molecular Cell Biology - In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific recruitment of enzymes to the plasma...

rdcu.be

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