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brookscrickard1.bsky.social @brookscrickard1.bsky.social · 11d

What is the over/under they end up in the wrong Portland...

Reposted

Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · 16d

WE'RE HIRING: Cornell University’s Weill Institute for Cell & Molecular Biology and the Department of Molecular Biology & Genetics are seeking a tenure-track Assistant Professor whose research integrates cell and molecular biology with an evolutionary perspective.
apps.hr.cornell.edu/recruiting/f...

Academic Career Opportunities

apps.hr.cornell.edu

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Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · 20d

🌟 Congratulations to @weillinstitute.bsky.social founding director Scott Emr, on winning the prestigious World Laureate Association Prize! His landmark work on the ESCRT pathway reshapes our understanding of infection, cancer & neurodegeneration. 🌟

news.cornell.edu/stories/2025...

Emr wins the World Laureate Association Prize | Cornell Chronicle

Scott Emr, the Samuel C. and Nancy M. Fleming Professor Emeritus in the College of Arts and Sciences, has won the World Laureate Association Prize, one of the world’s highest-funded scientific awards.

news.cornell.edu

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · 21d

Just throwing this out there as a significant conceptual advance in the field

www.biorxiv.org/content/10.1...

The Eukaryotic homology search complex distorts donor DNA structure to probe for homology

Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair proc...

www.biorxiv.org

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Cohen Lab @Cornell @cohenlab.bsky.social · Jun 9

I couldn’t be more proud of this tremendous work by Dr @awood2.bsky.social in my lab, co-led by myself and @idwolff.bsky.social. Anna worked tirelessly to conduct a comprehensive analysis of female meiosis, showing that CNTD1 plays role in crossover designation and checkpoint regulation in females.

Journal of Cell Biology @jcb.org · Jun 9

@awood2.bsky.social, Wolff et al. @cohenlab.bsky.social‬ @cornellrepro.bsky.social‬ show that cyclin N-terminal domain containing 1 (CNTD1) is a critical regulator of crossover formation during prophase I of #meiosis in females. rupress.org/jcb/article/...

#Genetics #CellCycle #CellDivision

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Kara Bernstein @karabernstein.bsky.social · Sep 3

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · Aug 29

Here is a link to a new pre-print that is a collaborative effort between our lab and the lab of Michelle Wang here at Cornell.

We use single-molecule techniques to investigate how the combination of Rad51 and Rad54 remodels donor DNA during the homology search

www.biorxiv.org/cgi/content/...

The Eukaryotic homology search complex distorts donor DNA structure to probe for homology

Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair proc...

www.biorxiv.org

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Reposted

Heather Feaga @heatherfeaga.bsky.social · Aug 28

Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to @isabellalin.bsky.social who left for grad school this week and her mentor @cassidyprints.bsky.social! www.biorxiv.org/content/10.1...

Conservation of sporulation genes and a transmembrane-containing Spo0B variant in Paenibacillus

Sporulation is a strategy employed by many bacteria to survive harsh environmental conditions. The genus Paenibacillus includes spore-forming species notorious for spoiling pasteurized dairy products ...

www.biorxiv.org

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Joe Peters Lab @joepeterslab.bsky.social · Aug 28

De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems www.biorxiv.org/content/10.1...

De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems

Programmable DNA integration using CRISPR-associated transposons (CASTs) offers powerful capabilities for genome engineering. The single effector Cas12k CAST examples evolved from a fixed guide TnpB n...

www.biorxiv.org

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · Aug 27

Things seen today on campus:
A coyote leading a slow speed chase of police

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Reposted

Aurele Piazza @aurelepiazza.bsky.social · Aug 27

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · Aug 27

Unicellular organisms still rule the Earth.

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · Aug 26

We've reached wild animals roaming campus unchecked level of dystopia...

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Shaun Mahony @shaunmahony.bsky.social · Aug 23

New preprint from the lab: Dr. Daniela James led an effort to improve the ChIP-exo protocol for high-res protein-DNA interactions. Particularly focused on optimizing for use in mammalian cells and making the protocol compatible with newer Illumina sequencers.
www.biorxiv.org/content/10.1...

Optimized ChIP-exo for mammalian cells and patterned sequencing flow cells

By combining chromatin immunoprecipitation (ChIP) with an exonuclease digestion of protein-bound DNA fragments, ChIP-exo characterizes genome-wide protein-DNA interactions at near base-pair resolution...

www.biorxiv.org

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · Aug 21

a group of cartoon characters are standing in front of a christmas tree and looking surprised .

ALT: a group of cartoon characters are standing in front of a christmas tree and looking surprised .

media.tenor.com

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

The Sinha Lab

The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

sinha.biochem.utah.edu

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Meng Wang @drmengwang.bsky.social · Aug 21

New publication from our lab! It was really fun writing this review @jcb.org with my postdoc Dr. Chris Mellor and graduate student Elisabeth Larson. We explore how folate deficiency trigger DNA damage that disrupt genome stability.

Journal of Cell Biology @jcb.org · Aug 18

New review: Mellor, Larson, and @drmengwang.bsky.social discuss the molecular mechanisms of mammalian genomic instability arising from folate deficiency and how this impacts genome biology in health and disease. rupress.org/jcb/article/...

#CellMetabolism

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Reposted

Heather Feaga @heatherfeaga.bsky.social · Aug 19

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...

Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio

Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...

journals.asm.org

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Ahmad Jomaa @jomaalab.bsky.social · Aug 1

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

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Ruben Gonzalez @rubenlgonzalez.bsky.social · Jul 31

New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · Jul 24

South Park has never disappointed

brookscrickard1.bsky.social @brookscrickard1.bsky.social · Jul 17

I've reached a new level of success in my academic career. Things are simultaneously amazing and awful at the same time.

brookscrickard1.bsky.social @brookscrickard1.bsky.social · Jul 2

Penn says there are five lights

brookscrickard1.bsky.social @brookscrickard1.bsky.social · Jun 17

a cartoon of charlie brown standing on a sidewalk with the words `` good grief '' written on it .

ALT: a cartoon of charlie brown standing on a sidewalk with the words `` good grief '' written on it .

media.tenor.com

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brookscrickard1.bsky.social @brookscrickard1.bsky.social · Jun 12

Drosophila embryos are logistically very challenging.

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