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Reposted by Soham Mukhopadhyay

Maite Saura @maitesaura.bsky.social · 28d

New preprint! 🐛 Root-knot nematodes hijack root cells, turning them into feeding sites and making plants very sick. Using a cross-species scRNA-seq approach we mapped this process and show how this knowledge can be used to engineer resistant crops.🌱 A summary🧵 :
www.biorxiv.org/content/10.1...

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Reposted by Soham Mukhopadhyay

Yasin Dagdas @plantophagy.bsky.social · Sep 4

“from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.”

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Reposted by Soham Mukhopadhyay

Zoe Bernasconi @zoebernasconi.bsky.social · Sep 1

Check out our new pre-print! ✨
We cloned AvrWTK4, the first wheat powdery mildew effector recognised by a tandem kinase protein, and show that an HMA-like integrated domain in WTK4 acts as pathogen decoy. Discover the whole story on bioRxiv ⬇️

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 29

An HMA-like integrated domain in the wheat tandem kinase WTK4 recognises an RNase-like pathogen effector https://www.biorxiv.org/content/10.1101/2025.08.26.672365v1

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Reposted by Soham Mukhopadhyay

James Lingford @jameslingford.bsky.social · Sep 1

Fantastic review on methodological developments in protein structural phylogenetics
academic.oup.com/gbe/article/...

Protein Structural Phylogenetics

Abstract. Protein structural phylogenetics is an interdisciplinary branch of molecular evolution that (i) uses 3D structural data to trace evolutionary his

academic.oup.com

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Soham Mukhopadhyay @sohambio.bsky.social · Sep 1

a new clubroot susceptibility gene discovered through GWAS

Gang Yu @gangyuplant.bsky.social · Sep 1

Inactivation of β-1,3-glucan synthase-like 5 confers broad-spectrum resistance to Plasmodiophora brassicae pathotypes in cruciferous plants
www.nature.com/articles/s41...

Inactivation of β-1,3-glucan synthase-like 5 confers broad-spectrum resistance to Plasmodiophora brassicae pathotypes in cruciferous plants - Nature Genetics

This study implicates GSL5 inactivation in high, broad-spectrum resistance to the clubroot pathogen Plasmodiophora brassicae in Arabidopsis thaliana, Brassica napus, Brassica oleracea and Brassica rap...

www.nature.com

Reposted by Soham Mukhopadhyay

Sophien Kamoun @kamounlab.bsky.social · Aug 28

First a pentamer, then a hexamer… now an octamer!

The riddle of the enigmatic CCG10-NLR immune receptor family cracked open 🔥

Congrats Guanghao @GuanghaoGuo He Zhang @mhz1989 Selva @M__Selvaraj et al.

#NLRbiology #plantsci #immunology

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Soham Mukhopadhyay @sohambio.bsky.social · Aug 26

Today's going exceptionally well 😅. Our paper describing the screening of Arabidopsis natural accessions against a Canadian clubroot pathotype is out now!

Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · Aug 26

What are the odds? 🤯
A second paper out today—this time revealing a new source of clubroot resistance in Arabidopsis! 🌱🛡️

Congratulations Melaine González García (@melainegg.bsky.social) 🎉!

Check it out here 👉 apsjournals.apsnet.org/doi/10.1094/...

Arabidopsis ecotype screening reveals novel sources of clubroot resistance | Plant Disease

Clubroot, caused by Plasmodiophora brassicae, poses a persistent threat to Brassicaceae crops, particularly in regions where resistant cultivars are under strong selection pressure. To identify new so...

apsjournals.apsnet.org

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Soham Mukhopadhyay @sohambio.bsky.social · Aug 26

Glad to see this out! We discussed the confusion around the ever-growing list of clubroot resistance genes and what truly qualifies as the novel ones. The clubroot community needs a consistent nomenclature to keep track of the real progress. @jiaxuwu.bsky.social , @edelplopez.bsky.social

Trends in Genetics @cp-trendsgenetics.bsky.social · Aug 26

"Déjà Vu in Clubroot Resistance: Same Genes, New Names"
by Edel Pérez-López (@edelplopez.bsky.social) & colleagues

"If we want meaningful progress...we must critically re-evaluate what qualifies as a truly novel R gene."

FREE access till Oct. 15th here:
authors.elsevier.com/a/1lg2acQbJF...

Figure 1. Nucleotide-binding site leucine-rich repeat (NLRs) and clubroot resistance (CR) genes in Brassica species.

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Reposted by Soham Mukhopadhyay

Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · Aug 26

Happy to see this out! @jiaxuwu.bsky.social, @sohambio.bsky.social & I tackle the growing confusion in clubroot resistance gene naming. We call for a common nomenclature and a shared database to speed up durable resistance 🧬 🥦

Thank you @cp-trendsgenetics.bsky.social for a great editorial process!

Trends in Genetics @cp-trendsgenetics.bsky.social · Aug 26

"Déjà Vu in Clubroot Resistance: Same Genes, New Names"
by Edel Pérez-López (@edelplopez.bsky.social) & colleagues

"If we want meaningful progress...we must critically re-evaluate what qualifies as a truly novel R gene."

FREE access till Oct. 15th here:
authors.elsevier.com/a/1lg2acQbJF...

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Reposted by Soham Mukhopadhyay

Fantin Mesny @mesny.bsky.social · Aug 15

📣 NEW PREPRINT 📝

We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...

cc @teamthomma.bsky.social

Plant-associated fungi co-opt ancient antimicrobials for host manipulation

Evolutionary histories of effector proteins secreted by fungal pathogens to mediate plant colonization remain largely elusive. While most functionally characterized effectors modulate plant immunity, ...

www.biorxiv.org

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Reposted by Soham Mukhopadhyay

Thorsten Langner @thorstenlangner.bsky.social · Aug 13

We’re excited to share our latest work on plant pathogen effector protein evolution @biorxivpreprint.bsky.social. With @kamounlab.bsky.social and Abbas Maqbool.

www.biorxiv.org/content/10.1...

Rewinding the tape: historical contingency and functional constraints have shaped the evolution of APikL virulence effectors in the blast fungus

Protein evolution is influenced by historical contingencies and functional constraints, but their combined impact on rapidly diversifying pathogen virulence effectors remains poorly understood. Here, ...

www.biorxiv.org

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Soham Mukhopadhyay @sohambio.bsky.social · Aug 4

Thanks @plantphys.bsky.social for the highlight! Aquatic plants are beautiful and it's really cool to observe oxygen bubbles being produced realtime during photosynthesis! Pics from my old tank-

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Reposted by Soham Mukhopadhyay

Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · Jul 31

2️⃣ PhD Positions in the lab:
📢 #1: Microbiome Diversity and Evolution in Leafhoppers Across Canada
📢 #2: Morphological Changes in Plant Roots Induced by Plasmodiophorid Effectors

📨 To apply submit :
* A cover letter
* Your curriculum vitae
* Academic transcripts
Applications: [email protected]

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Reposted by Soham Mukhopadhyay

Sorek Lab @soreklab.bsky.social · Jul 30

We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology

www.nature.com/articles/s41...

Was fun to write this piece with Dina Hochhauser!

Here is a thread to explain the premises

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Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology

Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...

www.nature.com

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Reposted by Soham Mukhopadhyay

Sorek Lab @soreklab.bsky.social · Jul 25

Wow - an important component of a central human innate immune pathway was discovered based on homology to a bacterial anti-phage defense system

A beautiful example showing how new knowledge on bacterial immunity translates to discoveries important for human health

Aude Bernheim @audeber.bsky.social · Jul 24

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

www.science.org

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Reposted by Soham Mukhopadhyay

Pingtao Ding (he/him) @dinglab.bsky.social · Jul 23

Three back-to-back Salicylic Acid biosynthesis papers 1/3 www.nature.com/articles/s41...

Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants - Nature

The salicylic acid (SA) biosynthesis pathway—involving ligation of benzoyl coenzyme A and benzyl alcohol to give benzyl benzoate; hydroxylation of benzyl benzoate to give benzyl salicylate; and cleava...

www.nature.com

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Reposted by Soham Mukhopadhyay

Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · Jul 23

Honored to share my journey and more importantly, how we can support the next generation of scientists in navigating the challenges of scientific mobility 🌍

Thank you @cp-trendsmicrobiol.bsky.social for this initiative and for giving visibility to stories that otherwise would have remained hidden 👏

Trends in Microbiology @cp-trendsmicrobiol.bsky.social · Jul 23

Two more articles in our series on 'Scientific mobility in microbiology' are online now.

Read @edelplopez.bsky.social and @tatsuyanobori.bsky.social's mobility-related experiences and their insights here: authors.elsevier.com/a/1lTnY,L%7E... & authors.elsevier.com/a/1lTnY_,2Ci...

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Reposted by Soham Mukhopadhyay

Tatsuya Nobori @tatsuyanobori.bsky.social · Jul 16

www.nature.com/articles/s41... Remodelling autoactive NLRs for broad-spectrum immunity in plants

Remodelling autoactive NLRs for broad-spectrum immunity in plants - Nature

Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.

www.nature.com

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Reposted by Soham Mukhopadhyay

Armin Djamei @effectomics.bsky.social · Jul 16

#2025ISMPMI tremendous effector-NLR screen with 1617 plants presented by Yin Yan. Following up new avr-R gene couples.

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Reposted by Soham Mukhopadhyay

Yu Sugihara @yusugihara.bsky.social · Jul 16

🎉 Exciting news during #2025ISMPMI
Our AlphaFold sensor vs helper NLR paper is now published in @newphyt.bsky.social‬!

Big thanks to the reviewers for their constructive feedback 🙏

📖 Check out the peer-reviewed version here 👇
🔗 nph.onlinelibrary.wiley.com/doi/10.1111/...

bsky.app/profile/yusu...

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Reposted by Soham Mukhopadhyay

Dani Stevens, Ph.D. @danimstevens.bsky.social · Jul 15

Mamp-ml was built upon two decades of foundational research. To generate the training data required, I manually pulled receptor and epitope sequences from every paper I could find, small or large. In total, we were able to capture over 1,300+ combinations across 11 receptors and 91 plant species.

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Reposted by Soham Mukhopadhyay

Sebastian Schornack @dromius.bsky.social · Jul 13

#2025ISMPMI Rotem @SorekLab encourages the audience to start studying those components of the plant immune system that have not been studied yet. Luckily there is more than TIR and CC NLRs in plants.

academic.oup.com/plcell/artic...

The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages

Plant immunity mediated by a major class of immune receptors is conserved among flowering and nonflowering plants, and these receptors have domains with si

academic.oup.com

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Reposted by Soham Mukhopadhyay

Javier Sánchez-Martín @javicheztin.bsky.social · Jul 9

Check out our work on virulence on Pm4 controlled not by one, but two effectors! Avirulence vs. Suppression, a beautiful case of the arms race between wheat and mildew. Work led by @zoebernasconi.bsky.social , Aline Herger, Pilar Caro, and @lukas-kunz.bsky.social 😍🌱🦠!
www.biorxiv.org/content/10.1...

Virulence on Pm4 kinase-based resistance is determined by two divergent wheat powdery mildew effectors

The wheat resistance gene Pm4 encodes a kinase fusion protein and has gained particular attention as it confers race-specific resistance against two major wheat pathogens: powdery mildew and blast. He...

www.biorxiv.org

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Soham Mukhopadhyay @sohambio.bsky.social · Jul 9

What do you mean by "effectors were declared dead"? 🤔

Soham Mukhopadhyay @sohambio.bsky.social · Jul 4

Amazing results! During my PhD, I found the lateral root assiociated genes to be constantly enriched in the transcriptome data from another gall forming pathogen Plasmodiophora brassicae.
www.e-bip.org.pl/upload/00889...

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