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SPPIRIT Network @sppirit-network.bsky.social · 8d

Hi Anna, you should receive the link via email very soon 🙂

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SPPIRIT Network @sppirit-network.bsky.social · 8d

📢 Just 1 month to go until our SPPIRIT ECR symposium

📝 Abstract deadline extended to 10 October 2025 - don’t miss out!

SPPIRIT Network @sppirit-network.bsky.social · 26d

📢 7 weeks to go until our SPPIRIT symposium

A fantastic opportunity for ECR parasitologists across Scotland to network and showcase their research.

🗓️ 31 October 2025 | 📍 Roslin Institute, Edinburgh
🎟️ Free to attend → tinyurl.com/3yzjnm5h

Secure your spot today!

Hostbusters: SPPIRITed to Roslin

Bringing together ECR parasitologists from across Scotland to network and showcase their science.

tinyurl.com

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SPPIRIT Network @sppirit-network.bsky.social · 26d

📢 7 weeks to go until our SPPIRIT symposium

A fantastic opportunity for ECR parasitologists across Scotland to network and showcase their research.

🗓️ 31 October 2025 | 📍 Roslin Institute, Edinburgh
🎟️ Free to attend → tinyurl.com/3yzjnm5h

Secure your spot today!

Hostbusters: SPPIRITed to Roslin

Bringing together ECR parasitologists from across Scotland to network and showcase their science.

tinyurl.com

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Reposted by SPPIRIT Network

University of Glasgow School of Infection & Immunity @uofgsii.bsky.social · 27d

🆕 | @uofgsii.bsky.social's Professor Rick Maizels has been prominently featured in a fascinating Freethink* article exploring the surprising relationship between parasitic worms and the human immune system.

👉 Full story: www.gla.ac.uk/schools/infe...

🗞️ Article: www.freethink.com/biotech/worm...

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Reposted by SPPIRIT Network

Dr Joanne Power @hanniepower.bsky.social · 27d

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟

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SPPIRIT Network @sppirit-network.bsky.social · 27d

Our next Parents of Parasites meeting is coming up! ☕👶

Being a parent in academia can feel isolating - join our virtual coffee break to connect, share experiences, and support each other.

📅 22nd September
🕒 2:00 PM

👉 SPPIRIT members: check your inbox
👉 Non-members: email or DM us to join

SPPIRIT Network @sppirit-network.bsky.social · 27d

Don't miss the chance to learn from an industry expert in drug discovery and connect with the Tryps Club community! 🌍✨

Leon Walther @trypsleon.bsky.social · Sep 4

Join us for the first Career Talk of the 2025–2026 Tryps Club season!

Prof. Paul M. Selzer will give us an insight into anti-parasitic drug development in industry.

📅 Date: 24.09.2025
🕒 Time: 12:00 pm BST
📍 Location: Zoom

Register following link or the QR code on the poster
lnkd.in/eA7b9QRx

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Reposted by SPPIRIT Network

Richard McCulloch @rmc9z.bsky.social · Aug 15

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social

www.sciencedirect.com/science/arti...

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events

DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…

www.sciencedirect.com

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Reposted by SPPIRIT Network

The Reece Lab @reecelab.bsky.social · Aug 15

🚨NEW PAPER🚨 We've already shown mosquito infections vary by time-of-day, here we test whether infection of mice FROM mosquitoes vary in a rhythmic manner. We test this in untreated & drug treated mice as some fitness consequences are only apparent in stressful environments doi.org/10.1186/s130...

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SPPIRIT Network @sppirit-network.bsky.social · Aug 15

The paper we will discuss:
bmcmethods.biomedcentral.com/articles/10....

SPPIRIT Network @sppirit-network.bsky.social · Aug 15

Only one week left until SPPIRIT Forum meeting! Join us to discuss recent work on mosquito tissue ultrastructure-expansion microscopy for malaria research, and ask questions to the 1st author, @benliffner.bsky.social, who will join us!
For meeting link fill in: tinyurl.com/3j5ewezv

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Reposted by SPPIRIT Network

Bungo Akiyoshi @bungoakiyoshi.bsky.social · Aug 6

My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...

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Reposted by SPPIRIT Network

Andrew S. MacDonald @profandrewmac.bsky.social · Jul 28

A real pleasure to be a part of this beautiful new study on T cell responses in repeat controlled human infection vs natural infection with #schistosomes, spearheaded by @emmahoulder.bsky.social with many wonderful colleagues #helminths #ImmunoSky #IDSky 🪱 🧪 www.nature.com/articles/s41...

T cell responses in repeated controlled human schistosome infection compared to natural exposure - Nature Communications

In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma mansoni infection, designed...

www.nature.com

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SPPIRIT Network @sppirit-network.bsky.social · Jul 31

On our first meeting on the 22nd of August, we will discuss an exciting recent study on ultrastructure-expansion microscopy of mosquito tissue for malaria research. Looking forward seeing you there! bmcmethods.biomedcentral.com/articles/10....

Mosquito Tissue Ultrastructure-Expansion Microscopy (MoTissU-ExM) enables ultrastructural and anatomical analysis of malaria parasites and their mosquito - BMC Methods

Background Study of malaria parasite cell biology is challenged by their small size, which can make visualisation of individual organelles difficult or impossible using conventional light microscopy. ...

bmcmethods.biomedcentral.com

SPPIRIT Network @sppirit-network.bsky.social · Jul 31

We would like to invite you to join our brand new SPPIRIT Forum! This series of online meetings aims to bring parasitologists together to discuss science, funding opportunities, etc.
For more info, join our mailing list: tinyurl.com/3j5ewezv

The SPPIRIT Forum

SPPIRIT would like to invite you to join our series of meetings - the SPPIRIT Forum! The forum is a platform where we will discuss parasitology, funding applications, experimental methods, and other t...

tinyurl.com

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SPPIRIT Network @sppirit-network.bsky.social · Jul 28

🚨 Postdoc alert! Our former committee member @macleanlab.bsky.social is looking for a postdoc to work on Toxoplasma metabolism in his lab. Great opportunity to do cool science in a beautiful city! 🧪🤝

Andrew Maclean @macleanlab.bsky.social · Jul 23

📣 Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Postdoctoral Research Associate

We are looking for a talented and enthusiastic Postdoctoral researcher to join the Maclean lab to investigate the metabolism of the human parasite Toxoplasma gondii.

elxw.fa.em3.oraclecloud.com

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Reposted by SPPIRIT Network

Medicines for Malaria Venture (MMV) @mmv.org · Jul 17

MMV, @LPIXEL_Inc & @dundeeuni are partnering to accelerate #malaria drug discovery using advanced AI-powered image analysis. This partnership aims to develop a platform that could shave months off the process of screening & selecting compounds. Learn more: bit.ly/44Roq5o

MMV announces new partnership using AI-powered image analysis to accelerate malaria drug discovery | Medicines for Malaria Venture

MMV announces new partnership using AI-powered image analysis to accelerate malaria drug discovery. The platform will improve identification of compounds with novel modes of action that can help comba...

bit.ly

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Reposted by SPPIRIT Network

labwyllie.bsky.social @labwyllie.bsky.social · Jul 9

Delighted our latest paper is now published in Science Translational Medicine. Fantastic collab with Dr Avninder Bhambra and his team. Our studies reveal promising quinazolines selectively target KRS in T. cruzi. www.science.org/doi/10.1126/...
@dundee.ac.uk

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease

Quinazolines targeting Trypanosoma cruzi lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

www.science.org

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Reposted by SPPIRIT Network

Manu De Rycker @mdr-ddu.bsky.social · Jul 9

Great to have a latest #Chagas disease drug discovery paper published in @rsc.org MedChem: pubs.rsc.org/en/content/a...

This work highlights how we decide to progress or terminate series, and hopefully provides some useful approaches and lessons.

@ddu-dundee.bsky.social 🧪 #NTD #drugdiscovery

Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi), is responsible for a large health burden with around 6–8 million people infected globally. The current dru...

pubs.rsc.org

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Reposted by SPPIRIT Network

Heather Ferguson @drheatherferg.bsky.social · Jul 8

New paper led by Joel Odero from the #VectorsGlasgow team in @sbohvm.gla.ac.uk and #IfakaraHealthInstitute
⬇️
Genomic evidence of spatially structured gene flow and divergent insecticide resistance backgrounds of the malaria vector Anopheles funestus in Tanzania academic.oup.com/genetics/art...

Genomic evidence of spatially structured gene flow and divergent insecticide resistance backgrounds of the malaria vector Anopheles funestus in Tanzania

Abstract. Population genetic analysis of mosquitoes is important for understanding the distribution of insecticide resistance alleles, devising sustainable

academic.oup.com

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SPPIRIT Network @sppirit-network.bsky.social · Jul 9

🚨 Postdoc alert! Amazing opportunity to work on Toxoplasma with @youngtoxolab.bsky.social in Edinburgh. Check it out!

Joanna Young @youngtoxolab.bsky.social · Jul 8

Postdoc position open to investigate chronic Toxoplasma infection!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Postdoctoral Research Associate

We are looking for a talented and enthusiastic Postdoctoral researcher to join the Young lab to investigate secreted proteins during chronic Toxoplasma gondii infection.

elxw.fa.em3.oraclecloud.com

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Reposted by SPPIRIT Network

Marketa Novotna @marketanovotna.bsky.social · Jul 6

I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications

Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...

www.nature.com

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Reposted by SPPIRIT Network

Faria Tryps Lab @fariatrypslab.bsky.social · Jul 5

www.nature.com/articles/s41...

Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications

Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...

www.nature.com

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Reposted by SPPIRIT Network

labwyllie.bsky.social @labwyllie.bsky.social · Jun 11

New paper alert! Enjoy!
pubs.acs.org/doi/10.1021/...

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b

Chemotherapy remains a key component of the arsenal of tools to fight malaria. Specifically, new drugs with diverse mechanism(s) of action are required to combat existing drug resistance. Here, we des...

pubs.acs.org

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Reposted by SPPIRIT Network

Trends in Parasitology @cp-trendsparasitol.bsky.social · May 27

Drs Kyrie Dickson, Jaime Costales, Malgorzata Domagalska, Ferre Veken & Martin Llewellyn discuss #genome (dis)organisation in #Trypanosoma #cruzi: innovation through #instability? #Adaptation #Chagas #Aneuploidy #Trypanosomatids

www.cell.com/trends/paras...

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